المؤلفون: Dunne, Jessica L., Richardson, Sarah J., Atkinson, Mark A., Craig, Maria E., Dahl-Jørgensen, Knut, Flodström-Tullberg, Malin, Hyöty, Heikki, Insel, Richard A., Lernmark, Åke, Lloyd, Richard E., Morgan, Noel G., Pugliese, Alberto

المصدر: Diabetologia EXODIAB: Excellence of Diabetes Research in Sweden. 62(5):744-753

مصطلحات موضوعية: Antiviral therapy, Autoimmunity, Beta cells, Enterovirus, Pancreas, Prevention, Type 1 diabetes, Vaccine, Virus, Medicin och hälsovetenskap, Klinisk medicin, Endokrinologi och diabetes, Medical and Health Sciences, Clinical Medicine, Endocrinology and Diabetes, Infektionsmedicin, Infectious Medicine

الوصول الحر: https://lup.lub.lu.se/record/36217fce-5457-4b6d-b700-f341b29028c9Test
http://dx.doi.org/10.1007/s00125-019-4811-7Test

المؤلفون: Sioofy-Khojine, Amir-Babak, Richardson, Sarah J., Locke, Jonathan M., Oikarinen, Sami, Nurminen, Noora, Laine, Antti-Pekka, Downes, Kate, Lempainen, Johanna, Todd, John A., Veijola, Riitta, Ilonen, Jorma, Knip, Mikael, Morgan, Noel G., Hyöty, Heikki, Peakman, Mark, Eichmann, Martin

المساهمون: HUS Children and Adolescents, Children's Hospital, University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism

مصطلحات موضوعية: Autoimmunity, Enterovirus, Genetic risk, IFIH-1, Interferon induced with helicase C domain 1, MDA5, Melanoma differentiation-associated protein 5, Pancreatic islets, rs1990760, Type 1 diabetes, CAPSID PROTEIN VP1, RIG-I, FUNCTION MUTATIONS, HLA GENOTYPES, INFECTION, CHILDREN, RECOGNITION, EXPRESSION, DIAGNOSIS, MELLITUS, 3121 General medicine, internal medicine and other clinical medicine

وصف الملف: application/pdf

العلاقة: The study was supported by a centre grant Diabetes - Genes, Autoimmunity and Prevention (D-GAP) from the JDRF (1-2007-1803) to MP, JAT, P. Bingley (University of Bristol), T. Tree (King's College London) and D. Dunger (University of Cambridge), a JDRF Career Development Award (5-CDA-2014-221-A-N) to SJR, a JDRF research grant awarded to the network of Pancreatic Organ Donors - Virus (nPOD-V) consortium (JDRF 25-2012-516), a Medical Research Council project grant (MR/P010695/1) awarded to SJR and NGM, a strategic award to JAT from the JDRF (4-SRA-2017-473-A-N) and the Wellcome Trust (07212/A/15/Z) and by the European Commission (Persistent Virus Infection in Diabetes Network [PEVNET] Frame Programme 7, coordinated by HH, contract number 261441). The virus analyses in Tampere University were additionally funded by grants to HH from the Sigrid Juselius Foundation and the Academy of Finland (grant number 288671). This study also reports independent research supported by the National Institute of Health Research Exeter Clinical Research Facility. Funders were not involved in the design and conduct of the study, the collection, analysis and interpretation of the data, or the preparation, review or approval of the manuscript. As such, the content is solely the responsibility of the authors and does not necessarily represent the official views of the funders. For the purpose of open access, the author has applied a Creative Commons Attribution (CC BY) licence to any Author Accepted Manuscript version arising.; Sioofy-Khojine , A-B , Richardson , S J , Locke , J M , Oikarinen , S , Nurminen , N , Laine , A-P , Downes , K , Lempainen , J , Todd , J A , Veijola , R , Ilonen , J , Knip , M , Morgan , N G , Hyöty , H , Peakman , M & Eichmann , M 2022 , ' Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with disease stage ' , Diabetologia , vol. 65 , no. 10 , pp. 1701-1709 . https://doi.org/10.1007/s00125-022-05753-yTest; d4473333-8fbd-4218-a10a-f80e50209d00; http://hdl.handle.net/10138/348270Test; 000829987300001

الإتاحة: http://hdl.handle.net/10138/348270Test

المؤلفون: Sioofy-Khojine, Amir Babak, Richardson, Sarah J., Locke, Jonathan M., Oikarinen, Sami, Nurminen, Noora, Laine, Antti Pekka, Downes, Kate, Lempainen, Johanna, Todd, John A., Veijola, Riitta, Ilonen, Jorma, Knip, Mikael, Morgan, Noel G., Hyöty, Heikki, Peakman, Mark, Eichmann, Martin

المصدر: Sioofy-Khojine , A B , Richardson , S J , Locke , J M , Oikarinen , S , Nurminen , N , Laine , A P , Downes , K , Lempainen , J , Todd , J A , Veijola , R , Ilonen , J , Knip , M , Morgan , N G , Hyöty , H , Peakman , M & Eichmann , M 2022 , ' Detection of enterovirus RNA in peripheral blood mononuclear cells correlates with the presence of the predisposing allele of the type 1 diabetes risk gene IFIH1 and with ....

مصطلحات موضوعية: Autoimmunity, Enterovirus, Genetic risk, IFIH-1, Interferon induced with helicase C domain 1, MDA5, Melanoma differentiation-associated protein 5, Pancreatic islets, rs1990760, Type 1 diabetes

الإتاحة: https://doi.org/10.1007/s00125-022-05753-yTest
https://kclpure.kcl.ac.uk/portal/en/publications/de23ed99-fc4b-4d3c-8d30-4728337ea930Test
http://www.scopus.com/inward/record.url?scp=85134540850&partnerID=8YFLogxKTest

المؤلفون: Sioofy-Khojine, Amir-Babak, Richardson, Sarah J, Locke, Jonathan M, Oikarinen, Sami, Nurminen, Noora, Laine, Antti-Pekka, Downes, Kate, Lempainen, Johanna, Todd, John A, Veijola, Riitta, Ilonen, Jorma, Knip, Mikael, Morgan, Noel G, Hyöty, Heikki, Peakman, Mark, Eichmann, Martin

المساهمون: Sioofy-Khojine, Amir-Babak [0000-0001-5538-5153], Richardson, Sarah J [0000-0002-1160-6062], Locke, Jonathan M [0000-0001-9516-5251], Oikarinen, Sami [0000-0003-3901-6774], Nurminen, Noora [0000-0002-6798-7677], Laine, Antti-Pekka [0000-0003-4962-2882], Lempainen, Johanna [0000-0001-9893-1468], Todd, John A [0000-0003-2740-8148], Veijola, Riitta [0000-0002-6557-270X], Ilonen, Jorma [0000-0002-9973-2062], Knip, Mikael [0000-0003-0474-0033], Morgan, Noel G [0000-0003-1537-8113], Hyöty, Heikki [0000-0003-0370-4145], Peakman, Mark [0000-0003-3328-3513], Eichmann, Martin [0000-0002-8675-2822], Apollo - University of Cambridge Repository, Tampere University, BioMediTech, Department of Clinical Microbiology, Department of Paediatrics, HUS Children and Adolescents, Children's Hospital, University of Helsinki, CAMM - Research Program for Clinical and Molecular Metabolism

المصدر: Diabetologia. 65(10)

مصطلحات موضوعية: EXPRESSION, Adult, MDA5, Interferon-Induced Helicase, IFIH1, Endocrinology, Diabetes and Metabolism, Pancreatic islets, Insulins, CHILDREN, Autoimmunity, FUNCTION MUTATIONS, DIAGNOSIS, 3121 Internal medicine, IFIH-1, RIG-I, DEAD-box RNA Helicases, MELLITUS, INFECTION, Internal Medicine, Interferon induced with helicase C domain 1, Enterovirus Infections, Humans, Genetic Predisposition to Disease, Child, Alleles, Autoantibodies, Enterovirus, Genetic risk, CAPSID PROTEIN VP1, Melanoma differentiation-associated protein 5, RECOGNITION, rs1990760, HLA GENOTYPES, Type 1 diabetes, Diabetes Mellitus, Type 1, 3121 General medicine, internal medicine and other clinical medicine, Leukocytes, Mononuclear, RNA, 3111 Biomedicine

وصف الملف: application/pdf; text/xml; fulltext

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc3a0514c44ea99ffc8cceef715deb10Test
https://pubmed.ncbi.nlm.nih.gov/35867130Test

المؤلفون: Vecchio, Federica, Lo Buono, Nicola, Stabilini, Angela, Nigi, Laura, Dufort, Matthew J., Geyer, Susan, Rancoita, Paola Maria, Cugnata, Federica, Mandelli, Alessandra, Valle, Andrea, Leete, Pia, Mancarella, Francesca, Linsley, Peter S., Krogvold, Lars, Herold, Kevan C., Elding Larsson, Helena, Richardson, Sarah J., Morgan, Noel G., Dahl-Jørgensen, Knut, Sebastiani, Guido, Dotta, Francesco, Bosi, Emanuele, Battaglia, Manuela

المساهمون: Vecchio, Federica, Lo Buono, Nicola, Stabilini, Angela, Nigi, Laura, Dufort, Matthew J., Geyer, Susan, Rancoita, Paola Maria, Cugnata, Federica, Mandelli, Alessandra, Valle, Andrea, Leete, Pia, Mancarella, Francesca, Linsley, Peter S., Krogvold, Lar, Herold, Kevan C., Elding Larsson, Helena, Richardson, Sarah J., Morgan, Noel G., Dahl-Jørgensen, Knut, Sebastiani, Guido, Dotta, Francesco, Bosi, Emanuele, Battaglia, Manuela

مصطلحات موضوعية: Autoimmune disease, Autoimmunity, Immunology, Innate immunity

العلاقة: info:eu-repo/semantics/altIdentifier/wos/WOS:000445115700019; volume:3; issue:18; journal:JCI INSIGHT; http://hdl.handle.net/20.500.11768/86291Test; info:eu-repo/semantics/altIdentifier/scopus/2-s2.0-85056037710

الإتاحة: https://doi.org/20.500.11768/86291Test
https://doi.org/10.1172/jci.insight.122146Test
https://hdl.handle.net/20.500.11768/86291Test

المؤلفون: Chaffey, Jessica R., Young, Jay, Leslie, Kaiyven A., Partridge, Katie, Akhbari, Pouria, Dhayal, Shalinee, Hill, Jessica L., Wedgwood, Kyle C. A., Burnett, Edward, Russell, Mark A., Richardson, Sarah J., Morgan, Noel G.

المصدر: Scientific Reports; 8/2/2021, Vol. 11 Issue 1, p1-13, 13p

مصطلحات موضوعية: ENTEROVIRUS diseases, PANCREATIC beta cells, TYPE 1 diabetes, AUTOIMMUNITY, COXSACKIEVIRUSES

المؤلفون: Korpos, Éva, Kadri, Nadir, Loismann, Sophie, Findeisen, Clais R., Arfuso, Frank, Burke III, George W., Richardson, Sarah J., Morgan, Noel G., Bogdani, Marika, Pugliese, Alberto, Sorokin, Lydia

المصدر: Diabetologia; Jul2021, Vol. 64 Issue 7, p1626-1641, 16p

المؤلفون: Leete, Pia, Mallone, Roberto, Richardson, Sarah, J, Sosenko, Jay, M, Redondo, Maria, J, Evans-Molina, Carmella

المساهمون: Islet Biology Exeter Exeter, UK (IBEx), University of Exeter-Institute of Biomedical and Clinical Sciences Exeter, UK, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de diabétologie CHU Cochin, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin AP-HP, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Sorbonne Paris Cité (USPC), Hôpital Cochin AP-HP, Department of Medicine Miami, FL, USA (Diabetes Research Institute), University of Miami Leonard M. Miller School of Medicine (UMMSM)-University of Miami Coral Gables, Baylor College of Medicine (BCM), Baylor University, Departments of Medicine and Pediatrics Indianapolis, IN, USA, Indiana University School of Medicine, Indiana University System-Indiana University System-Herman B Wells Center for Pediatric Research Indianapolis, IN, USA -Roudebush VA Medical Center Indianapolis, IN, USA, This study was financially supported by the European Union’s Seventh Framework Programme PEVNET ( FP7/2007-2013) under grant agreement number 261441. The participants of the PEVNET consortium are described at http://www.uta.fi/med/pevnet/publications.htmlTest. Additional support was from a JDRF research grants awarded to the network of Pancreatic Organ Donors–Virus (nPOD-V) consortium (JDRF 25-2012-516 and JDRF-3-SRA-2017-492-A-N) and a JDRF Career Development Award (5-CDA-2014-221-A-N), an MRC Project Grant (MR/P010695/1) and project grant from Diabetes UK (16/0005480) all to SJR. This work was also supported by NIH grants R01 DK093954 and UC4 DK 104166 (to C.E.M.), U01 DK103180 (toM.R.), VA Merit Award I01BX001733 (to C.E.M.), a JDRF Strategic Research Agreement (2-SRA-2018-493-A-B), and gifts from the Sigma Beta Sorority, the Ball Brothers Foundation, the George and Frances Ball Foundation, and the Holiday Management Foundation, all to C.E.M. R.M. received grants from the JDRF (1-PNF-2014-155-A-V, 2-SRA-2016-164-Q-R), the Agence Nationale de la Recherche (ANR-2015-CE17-0018-01) and by the Innovative Medicines Initiative 2 Joint Undertaking (INNODIA, 115797), which receives support from the EU Horizon 2020 program, the European Federation of Pharmaceutical Industries and Associations, JDRF, and the Helmsley Charitable Trust., ANR-15-CE17-0018,TIBET,LA PRESSION ENVIRONNEMENTALE SUR UNE IMAGE ALTEREE DU SOI IMMUNITAIRE : VERS LA PREDICTION ET LA PREVENTION DU DIABETE DE TYPE 1(2015), European Project: 261441,EC:FP7:HEALTH,FP7-HEALTH-2010-single-stage,PEVNET(2011)

المصدر: ISSN: 1534-4827.

مصطلحات موضوعية: C-peptide, β cell, Type 1 diabetes, Autoimmunity, Age, [SDV.IMM]Life Sciences [q-bio]/Immunology

العلاقة: info:eu-repo/semantics/altIdentifier/pmid/30259209; info:eu-repo/grantAgreement/EC/FP7/261441/EU/Persistent virus infection as a cause of pathogenic inflammation in type 1 diabetes - an innovative research program of biobanks and expertise/PEVNET; inserm-01918835; https://inserm.hal.science/inserm-01918835Test; https://inserm.hal.science/inserm-01918835/documentTest; https://inserm.hal.science/inserm-01918835/file/Leete2018_Article_TheEffectOfAgeOnTheProgression.pdfTest; https://inserm.hal.science/inserm-01918835/file/Evans-Molina%20ms_clean.pdfTest; PUBMED: 30259209

الإتاحة: https://doi.org/10.1007/s11892-018-1083-4Test
https://inserm.hal.science/inserm-01918835Test
https://inserm.hal.science/inserm-01918835/documentTest
https://inserm.hal.science/inserm-01918835/file/Leete2018_Article_TheEffectOfAgeOnTheProgression.pdfTest
https://inserm.hal.science/inserm-01918835/file/Evans-Molina%20ms_clean.pdfTest

المؤلفون: Green, E. Allison, Cooke, Anne C., Piganelli, Jon D., Richardson, Sarah J., Wen, Li, Wong, F. Susan

المصدر: Frontiers in Immunology; 3/10/2022, Vol. 13, p1-3, 3p

مصطلحات موضوعية: TYPE 1 diabetes, AUTOIMMUNE diseases, REGULATORY B cells, REGULATORY T cells, ENTEROVIRUS diseases, LEUCOCYTE elastase, INNATE lymphoid cells, NLRP3 protein, T cell receptors

المؤلفون: Carré, Alexia, Richardson, Sarah J., Larger, Etienne, Mallone, Roberto

المصدر: Diabetologia; 2021, Vol. 64 Issue 1, p15-25, 11p