التفاصيل البيبلوغرافية
| العنوان: |
Kinase inhibitors: The next generation of therapies in the treatment of rheumatoid arthritis. |
| المؤلفون: |
MacFarlane, Lindsey A.1, Todd, Derrick J.1,2 |
| المصدر: |
International Journal of Rheumatic Diseases. May2014, Vol. 17 Issue 4, p359-368. 10p. |
| مصطلحات موضوعية: |
*RHEUMATOID arthritis treatment, *KINASE inhibitors, *PAIN management, *AUTOIMMUNITY, *METHOTREXATE, *MITOGEN-activated protein kinases, *PROTEIN-tyrosine kinases |
| مستخلص: |
Rheumatoid arthritis ( RA) can be the source of significant pain and functional limitation. The past 20 years have seen a transition in treatment goals away from mere pain management toward disease modification through the suppression of autoimmunity. Disease-modifying anti-rheumatic drugs, such as methotrexate and biologic agents, impair disease progression and joint destruction. However, despite these achievements, a substantial subset of RA patients does not respond to or cannot tolerate current treatments for RA. Scientific insight into the cellular pathways of inflammation has revealed new therapeutic targets for the treatment of autoimmune diseases like RA. Attention has focused on pathways mediated by Janus kinase ( JAK), mitogen-activated protein kinase ( MAPK), and spleen tyrosine kinase ( Syk). This review article summarizes the evidence supporting the use of various kinase inhibitors, including the newly approved JAK inhibitor tofacitinib, in the treatment of RA. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
Academic Search Index |
