التفاصيل البيبلوغرافية
| العنوان: |
Mapping Systemic Inflammation and Antibody Responses in Multisystem Inflammatory Syndrome in Children (MIS-C). |
| المؤلفون: |
Gruber, Conor N.1,2,3,4 (AUTHOR), Patel, Roosheel S.1,2,3,4 (AUTHOR), Trachtman, Rebecca1,2,3 (AUTHOR), Lepow, Lauren1,5 (AUTHOR), Amanat, Fatima4 (AUTHOR), Krammer, Florian4 (AUTHOR), Wilson, Karen M.2,3 (AUTHOR), Onel, Kenan3,5 (AUTHOR), Geanon, Daniel1 (AUTHOR), Tuballes, Kevin1 (AUTHOR), Patel, Manishkumar1 (AUTHOR), Mouskas, Konstantinos5 (AUTHOR), O'Donnell, Timothy5 (AUTHOR), Merritt, Elliot5 (AUTHOR), Simons, Nicole W.5 (AUTHOR), Barcessat, Vanessa1 (AUTHOR), Del Valle, Diane M.1 (AUTHOR), Udondem, Samantha5 (AUTHOR), Kang, Gurpawan5 (AUTHOR), Gangadharan, Sandeep3 (AUTHOR) |
| المصدر: |
Cell. Nov2020, Vol. 183 Issue 4, p982-982. 1p. |
| مصطلحات موضوعية: |
*ANTIBODY formation, *INFLAMMATION, *AUTOANTIBODIES, *CHEMOTAXIS, *SARS-CoV-2, *T cells, *CELLULAR pathology |
| مستخلص: |
Initially, children were thought to be spared from disease caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, a month into the epidemic, a novel multisystem inflammatory syndrome in children (MIS-C) emerged. Herein, we report on the immune profiles of nine MIS-C cases. All MIS-C patients had evidence of prior SARS-CoV-2 exposure, mounting an antibody response with intact neutralization capability. Cytokine profiling identified elevated signatures of inflammation (IL-18 and IL-6), lymphocytic and myeloid chemotaxis and activation (CCL3, CCL4, and CDCP1), and mucosal immune dysregulation (IL-17A, CCL20, and CCL28). Immunophenotyping of peripheral blood revealed reductions of non-classical monocytes, and subsets of NK and T lymphocytes, suggesting extravasation to affected tissues. Finally, profiling the autoantigen reactivity of MIS-C plasma revealed both known disease-associated autoantibodies (anti-La) and novel candidates that recognize endothelial, gastrointestinal, and immune-cell antigens. All patients were treated with anti-IL-6R antibody and/or IVIG, which led to rapid disease resolution. • The MIS-C anti-SARS-CoV-2 antibody repertoire resembles a convalescent response • Cytokine profiling indicates myeloid cell chemotaxis and mucosal inflammation • Mass cytometry uncovers immune cell activation and egress to the periphery • MIS-C autoantibodies target organ systems central to MIS-C pathology Insights into the cellular and serological immune dysfunction underlying MIS-C, a novel pediatric inflammatory syndrome associated with SARS-CoV-2 infection, reveal potential autoantibodies that may link organ systems relevant to pathology. [ABSTRACT FROM AUTHOR] |
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