التفاصيل البيبلوغرافية
| العنوان: |
Longitudinal Pathogenic Properties and N -Glycosylation Profile of Antibodies from Patients with Pemphigus after Corticosteroid Treatment. |
| المؤلفون: |
Petit, Marie, Walet-Balieu, Marie-Laure, Schapman, Damien, Golinski, Marie-Laure, Burel, Carole, Barray, Marion, Drouot, Laurent, Maho-Vaillant, Maud, Hébert, Vivien, Boyer, Olivier, Bardor, Muriel, Joly, Pascal, Calbo, Sébastien |
| المصدر: |
Biomedicines; Oct2021, Vol. 9 Issue 10, p1411, 1p |
| مصطلحات موضوعية: |
AUTOIMMUNE diseases, PEMPHIGUS, PEMPHIGUS vulgaris, IMMUNOGLOBULIN G, IMMUNOGLOBULINS, CORTICOSTEROIDS, AUTOANTIBODIES |
| مستخلص: |
Pemphigus vulgaris is an autoimmune disease that occurs due to pathogenic autoantibodies that recognize the following epidermal adhesion proteins: desmogleins. Systemic corticosteroids usually decrease the titers of anti-desmoglein autoantibodies and improve patients' conditions. Since modifications of IgG N-glycosylation have been described in some autoimmune diseases, we hypothesized that changes in the pathogenic activity of pemphigus IgG could be related to changes in their N-glycosylation profile. The purpose of this study was to assess, longitudinally, the pathogenicity of pemphigus serum IgG and their N-glycosylation profile during phases of disease activity and clinical remission. The pathogenic activity of serum IgG was measured in vitro on immortalized keratinocytes, by immunofluorescence and dissociation assays, and IgG N-glycans were analyzed by mass spectrometry. We showed (i) a correlation between pemphigus clinical activity and the pathogenicity of serum IgG at baseline and at month 6, while the persistence of the in vitro pathogenic activity of IgG during its evolution, even in patients in clinical remission, seemed to be predictive of relapse; (ii) that modifications of the N-glycan structure were altered the in vitro pathogenicity of patients' autoantibodies; (iii) that the pathogenic properties of pemphigus IgG did not appear to be related to the disparity in IgG N-glycans during the course of pemphigus. [ABSTRACT FROM AUTHOR] |
|
Copyright of Biomedicines is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder