التفاصيل البيبلوغرافية
| العنوان: |
Self-Antigens Targeted by Regulatory T Cells in Type 1 Diabetes. |
| المؤلفون: |
Mitchell, Angela M.1 (AUTHOR) angela.mitchell@cuanschutz.edu, Michels, Aaron W.1 (AUTHOR) aaron.michels@cuanschutz.edu |
| المصدر: |
International Journal of Molecular Sciences. Mar2022, Vol. 23 Issue 6, p3155-3155. 13p. |
| مصطلحات موضوعية: |
*REGULATORY T cells, *TYPE 1 diabetes, *T cells, *AUTOANTIGENS, *IMMUNOSUPPRESSION, *HLA histocompatibility antigens, *ISLANDS of Langerhans |
| مستخلص: |
While progress has been made toward understanding mechanisms that lead to the development of autoimmunity, there is less knowledge regarding protective mechanisms from developing such diseases. For example, in type 1 diabetes (T1D), the immune-mediated form of diabetes, the role of pathogenic T cells in the destruction of pancreatic islets is well characterized, but immune-mediated mechanisms that contribute to T1D protection have not been fully elucidated. One potential protective mechanism includes the suppression of immune responses by regulatory CD4 T cells (Tregs) that recognize self-peptides from islets presented by human leukocyte antigen (HLA) class II molecules. In this review, we summarize what is known about the antigenic self-peptides recognized by Tregs in the context of T1D. [ABSTRACT FROM AUTHOR] |
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