دورية أكاديمية
Dysregulation of germinal centres in autoimmune disease
| العنوان: | Dysregulation of germinal centres in autoimmune disease |
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| المؤلفون: | Garcia De Vinuesa, Maria Carola, Sanz, Inaki, Cook, Matthew |
| المصدر: | Nature Reviews Immunology |
| بيانات النشر: | Nature Publishing Group |
| المجموعة: | Australian National University: ANU Digital Collections |
| مصطلحات موضوعية: | Keywords: antigen, antinuclear antibody, autoantibody, cardiolipin, CD40 antigen, CD40 ligand, double stranded DNA, glucose 6 phosphate isomerase, intercellular adhesion molecule 1, interleukin 21 receptor, interleukin 4, protein bcl 6, rheumatoid factor, rituximab |
| الوصف: | In germinal centres, somatic hypermutation and B cell selection increase antibody affinity and specificity for the immunizing antigen, but the generation of autoreactive B cells is an inevitable by-product of this process. Here, we review the evidence that aberrant selection of these autoreactive B cells can arise from abnormalities in each of the germinal centre cellular constituents B cells, T follicular helper cells, follicular dendritic cells and tingible body macrophages or in the supply of antigen. As the progeny of germinal centre B cells includes long-lived plasma cells, selection of autoreactive B cells can propagate long-lived autoantibody responses and cause autoimmune diseases. Elucidation of crucial molecular signals in germinal centres has led to the identification of novel therapeutic targets. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | unknown |
| تدمد: | 1474-1733 |
| العلاقة: | http://hdl.handle.net/1885/33088Test; https://openresearch-repository.anu.edu.au/bitstream/1885/33088/5/Vinuesa-Cook_NatImm_Dysregulation.pdf.jpgTest; https://openresearch-repository.anu.edu.au/bitstream/1885/33088/7/01_Garcia+De+Vinuesa_Dysregulation_of_germinal_2009.pdf.jpgTest |
| DOI: | 10.1038/nri2637 |
| الإتاحة: | https://doi.org/10.1038/nri2637Test http://hdl.handle.net/1885/33088Test https://openresearch-repository.anu.edu.au/bitstream/1885/33088/5/Vinuesa-Cook_NatImm_Dysregulation.pdf.jpgTest https://openresearch-repository.anu.edu.au/bitstream/1885/33088/7/01_Garcia+De+Vinuesa_Dysregulation_of_germinal_2009.pdf.jpgTest |
| رقم الانضمام: | edsbas.DC526BBF |
| قاعدة البيانات: | BASE |
| تدمد: | 14741733 |
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| DOI: | 10.1038/nri2637 |