التفاصيل البيبلوغرافية
| العنوان: |
Self-paced timing detects and tracks change in prodromal Huntington disease. |
| المؤلفون: |
Rowe, KC, Paulsen, JS, Langbehn, DR, Duff, K, Beglinger, LJ, Wang, C, O'Rourke, JJ, Stout, JC, Moser, DJ |
| المصدر: |
Neuropsychology , 24 (4) pp. 435-442. (2010) |
| سنة النشر: |
2010 |
| مصطلحات موضوعية: |
Acoustic Stimulation, Adult, Aged, Attention, Auditory Perception, Cross-Sectional Studies, Female, Humans, Huntington Disease, Longitudinal Studies, Male, Middle Aged, Neuropsychological Tests, Psychomotor Performance, Self Concept, Time Perception, Young Adult, psy |
| الوصف: |
OBJECTIVE: This study compares self-paced timing performance (cross-sectionally and longitudinally) between participants with prodromal Huntington's disease (pr-HD) and a comparison group of gene non-expanded participants from affected families (NC). METHOD: Participants (747 pr-HD: 188 NC) listened to tones presented at 550-ms intervals, matched that pace by tapping response keys and continued the rhythm (self-paced) after the tone had stopped. Standardized cross-sectional and longitudinal linear models examined the relationships between self-paced timing precision and estimated proximity to diagnosis, and other demographic factors. RESULTS: Pr-HD participants showed significantly less timing precision than NC. Comparison of pr-HD and NC participants showed a significant performance difference on two task administration conditions (dominant hand: p < .0001; alternating thumbs: p < .0001). Additionally, estimated proximity to diagnosis was related to timing precision in both conditions, (dominant hand: t = -11.14, df = 920, p < .0001; alternating thumbs: t = -11.32, df = 918, p < .0001). Longitudinal modeling showed that pr-HD participants worsen more quickly at the task than the NC group, and rate of decline increases with estimated proximity to diagnosis in both conditions (dominant hand: t = -2.85, df = 417, p = .0045; alternating thumbs: t = -3.56, df = 445, p = .0004). Effect sizes based on adjusted mean annual change ranged from -0.34 to 0.25 in the longitudinal model. CONCLUSIONS: The self-paced timing paradigm has potential for use as a screening tool and outcome measure in pr-HD clinical trials to gauge therapeutically mediated improvement or maintenance of function. |
| نوع الوثيقة: |
article in journal/newspaper |
| اللغة: |
unknown |
| العلاقة: |
http://discovery.ucl.ac.uk/1390178Test/ |
| الإتاحة: |
http://discovery.ucl.ac.uk/1390178Test/ |
| حقوق: |
undefined |
| رقم الانضمام: |
edsbas.1DE44BD0 |
| قاعدة البيانات: |
BASE |
