Hypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network Connectivity
| العنوان: | Hypoglycemia Unawareness in T1DM Is Associated with Altered Brain Default Mode Network Connectivity |
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| المؤلفون: | Dongju Seo, Dustin Scheinost, Cheryl Lacadie, Janice Hwang, Rajita Sinha, Robert S. Sherwin, Todd Constable, Lisa Parikh, Renata Belfort-DeAguiar, Derek Groskreutz |
| المصدر: | Diabetes. 67 |
| بيانات النشر: | American Diabetes Association, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | Hypoglycemia unawareness, medicine.medical_specialty, Resting state fMRI, business.industry, Endocrinology, Diabetes and Metabolism, Audiology, Hypoglycemia, medicine.disease, Functional networks, Internal Medicine, medicine, Bold fmri, business, Default mode network |
| الوصف: | The impact of hypoglycemia awareness (HA) on brain resting state connectivity remains unclear. To examine the impact of HA on the default mode network (DMN), a functional network in the brain that is active during wakeful rest and associated with introspection, 12 T1DM individuals with hypo unawareness (T1DM-UW) (by Clarke score) (7F/5M, age 44±12 years, BMI 26.4±4.2 kg/m2, HbA1c 7.1±0.7) and 15 T1DM-Aware (AW) (10F/5M, age 30±7, BMI 24.5±3.1, HbA1C 7.1±0.9) individuals underwent resting state BOLD fMRI scanning to assess the DMN during a two-step euglycemic (Eu)-hypoglycemic (Hypo) clamp (90-60 mg/dl). T1DM-AW individuals exhibited a hypoglycemia-induced decrease in DMN connectivity (P Disclosure D. Groskreutz: None. J. Hwang: None. D. Seo: None. C. Lacadie: None. L. Parikh: None. R. Belfort-DeAguiar: Research Support; Self; GlaxoSmithKline plc.. D. Scheinost: None. R. Sinha: None. T. Constable: None. R. Sherwin: Other Relationship; Self; QuintilesIMS, MannKind Corporation. Research Support; Self; Regeneron Pharmaceuticals, Inc.. Other Relationship; Self; ICON plc.. |
| تدمد: | 1939-327X 0012-1797 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_________::f826baf4a7862c2c86f715e7710c34c9Test https://doi.org/10.2337/db18-11-lbTest |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi...........f826baf4a7862c2c86f715e7710c34c9 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1939327X 00121797 |
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