Representation of women, older patients, ethnic, and racial minorities in trials of atrial fibrillation
| العنوان: | Representation of women, older patients, ethnic, and racial minorities in trials of atrial fibrillation |
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| المؤلفون: | Aarthi Madhanakumar, Ahmad Naeem Lone, Swapna Talluri, Muhammad Usman Khan, Muhammad Zia Khan, Zain Ul Abideen Asad, Safi U. Khan, Erin D. Michos, Mohamad Alkhouli, Muhammad Shahzeb Khan, Charumathi Raghu Subramanian, Muhammad Bilal Munir |
| المصدر: | Pacing Clin Electrophysiol Pacing and clinical electrophysiology : PACE, vol 44, iss 3 |
| سنة النشر: | 2020 |
| مصطلحات موضوعية: | Male, Comparative Effectiveness Research, medicine.medical_specialty, Clinical Trials and Supportive Activities, Clinical Sciences, Population, Biomedical Engineering, MEDLINE, Ethnic group, ethnic minorities, Disease, 030204 cardiovascular system & hematology, Cardiovascular, Article, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Clinical Research, law, Epidemiology, Atrial Fibrillation, medicine, Humans, Women, 030212 general & internal medicine, education, American Indian or Alaska Native, Disease burden, Aged, Randomized Controlled Trials as Topic, education.field_of_study, racial minorities, business.industry, Age Factors, General Medicine, Heart Disease, Cardiovascular System & Hematology, randomized controlled trials, Ethnic and Racial Minorities, Pacific islanders, Female, Cardiology and Cardiovascular Medicine, business, Demography |
| الوصف: | Background Representation trends of women, older adults, and ethnic/racial minorities in randomized controlled trials (RCTs) of atrial fibrillation (AF) are uncertain. Methods We systematically reviewed 134 AF related RCTs (phase II and III) encompassing 149,162 participants using Medline and ClinicalTrials.gov through April 2019 to determine representation trends of women, older patients (≥75 years), and ethnic/racial minorities. Weighted data on the prevalence of AF from epidemiological studies were used to compare the representation of the studied groups of interest in AF RCTs to their expected burden of the disease. Results Only 18.7% of the RCTs reported proportion of older patients, and 12.7% RCTs reported ethnic/racial minorities. The proportions of women in RCTs versus general population were 35.2% and 35.1%, of Hispanics were 11.9% and 5.2%, of Blacks were 1.2% and 5.7%, of American Indian/Alaskans were 0.2% and 0.2%, of Asians were 14.2% and 2.4%, of native Hawaiian/Pacific Islanders were 0.05% and 0.1% and of non-Whites were 19.5% and 22.5%, respectively. The weighted mean age (SD) across the trials was 65.3 (3.2) years which was less than the corresponding weighted mean age of 71.1 (4.5) years in the comparative epidemiological data. Conclusion The reporting of older patients and ethnic/racial minorities was poor in RCTs of AF. The representation of women and American Indian/Alaskan natives matched their expected population share of disease burden. Hispanics and Asians were over-represented and Blacks, native Hawaiian/Pacific Islanders and non-Whites were under-represented in RCTs of AF. |
| وصف الملف: | application/pdf |
| تدمد: | 1540-8159 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e1cf8ff27c337c976b73c262a14922bTest https://pubmed.ncbi.nlm.nih.gov/33512027Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....6e1cf8ff27c337c976b73c262a14922b |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 15408159 |
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