دورية أكاديمية
Relationship between apical periodontitis and atherosclerosis in rats: lipid profile and histological study
| العنوان: | Relationship between apical periodontitis and atherosclerosis in rats: lipid profile and histological study |
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| المؤلفون: | Conti, L. C., Segura-Egea, J. J., Cardoso, C. B.M., Benetti, F., Azuma, M. M., Oliveira, P. H.C., Bomfim, S. R.M., Cintra, L. T.A. |
| المساهمون: | Universidade Estadual Paulista (UNESP) |
| سنة النشر: | 2020 |
| المجموعة: | Universidade Estadual Paulista São Paulo: Repositório Institucional UNESP |
| مصطلحات موضوعية: | apical periodontitis, atherosclerosis, endodontic medicine, systemic disorders |
| الوصف: | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) ; Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq) ; Processo FAPESP: 2016/08005-0 ; CNPq: 311650/2018-0 ; CNPq: 436122/2018-9 ; Aim: To investigate the relationship between apical periodontitis and atherosclerosis in rats by lipid profile and carotid artery intima tunic measurement, and histological and histometric evaluation of periapical lesions. Methodology: Forty male Wistar rats were allocated into four groups: control (C), with apical periodontitis (AP), with atherosclerosis (AT) and with AP and AT (AP + AT). Atherosclerosis was induced using a high-lipid diet associated with a surgical ligature in the carotid artery and a super dosage of vitamin D3. AP was induced via pulp exposure to the oral environment. At 45 and 75 days, serum levels of total cholesterol (TC), triglycerides (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were measured. The maxillary and mandibular jaws and carotid artery were collected and processed for histological analysis. The Kruskal–Wallis or Mann–Whitney test was performed for nonparametric data, and the Tukey’s or Student’s t-test was performed for parametric data (P ' 0.05). Results: In nonatherosclerotic animals, the induction of apical periodontitis increased TG levels significantly, from 63.1 ± 11.4 mg dL−1 in group C to 88.2 ± 7.9 mg dL−1 in the AP group (P ' 0.05). The induction of AP was associated with a trend for higher TC and LDL-C levels in atherosclerotic animals (P ' 0.05); however, it only significantly increased TG levels, from 93.2 ± 18.0 mg dL−1 in AT group to 121.9 ± 14.5 mg dL−1 in the AP + AT group (P ' 0.05). Animals in the AP + AT group had a 36.5% increase in the thickness of the carotid intima tunic when compared with the AT group (P ' 0.05). The intensity of the inflammatory infiltrate was significantly larger in the AP + AT group when compared with AP group (P ' 0.05). The AP + AT group exhibited significantly greater ... |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 1387-1397 |
| اللغة: | English |
| تدمد: | 1365-2591 0143-2885 |
| العلاقة: | International Endodontic Journal; http://dx.doi.org/10.1111/iej.13350Test; International Endodontic Journal, v. 53, n. 10, p. 1387-1397, 2020.; http://hdl.handle.net/11449/200766Test; 2-s2.0-85088091314 |
| DOI: | 10.1111/iej.13350 |
| الإتاحة: | https://doi.org/10.1111/iej.13350Test http://hdl.handle.net/11449/200766Test |
| رقم الانضمام: | edsbas.F5F176CD |
| قاعدة البيانات: | BASE |
| تدمد: | 13652591 01432885 |
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| DOI: | 10.1111/iej.13350 |