Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers
| العنوان: | Prospective Case-Control Study of Cardiovascular Abnormalities 6 Months Following Mild COVID-19 in Healthcare Workers |
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| المؤلفون: | Rishi K Patel, Thomas A. Treibel, George Joy, Erik B. Schelbert, Charlotte Manisty, Mahdad Noursadeghi, Katia Menacho, Áine McKnight, Hunain Shiwani, Andreas Seraphim, Hibba Kurdi, Jessica Artico, Gabriella Captur, Timothée Evain, Nikoo Aziminia, Marianna Fontana, Iain Pierce, Robert Adam, John P Greenwood, James T Brown, Liza Chacko, Marta Fontes Oliveira, George Thornton, Rhodri H. Davies, COVIDsortium Investigators, Peter Kellman, João B Augusto, James C. Moon, Mervyn Andiapen, Clement Lau, Anish N Bhuva |
| المصدر: | Jacc. Cardiovascular Imaging |
| بيانات النشر: | Elsevier BV, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Male, Contrast Media, Gadolinium, 030204 cardiovascular system & hematology, Ventricular Function, Left, 030218 nuclear medicine & medical imaging, 0302 clinical medicine, Natriuretic peptide, Prospective Studies, Prospective cohort study, Original Research, Ejection fraction, COVID-19, coronavirus disease-2019, LGE, late gadolinium enhancement, troponin, SARS-CoV-2, severe acute respiratory syndrome-coronavirus-2, Middle Aged, late gadolinium enhancement, Female, medicine.symptom, Cardiology and Cardiovascular Medicine, Adult, medicine.medical_specialty, Myocarditis, Adolescent, medicine.drug_class, Health Personnel, Cardiovascular Abnormalities, CMR, cardiovascular magnetic resonance, Magnetic Resonance Imaging, Cine, Asymptomatic, Young Adult, cardiovascular magnetic resonance, 03 medical and health sciences, Artificial Intelligence, Predictive Value of Tests, Internal medicine, medicine, Humans, Radiology, Nuclear Medicine and imaging, Seroconversion, LV, left ventricular, SARS-CoV-2, Vascular disease, business.industry, Myocardium, hsTnT, high-sensitivity troponin T, Case-control study, COVID-19, medicine.disease, Case-Control Studies, myocardial edema, NT-proBNP, N-terminal pro–B-type natriuretic peptide, myocarditis, business |
| الوصف: | Objectives The purpose of this study was to detect cardiovascular changes after mild severe acute respiratory syndrome coronavirus 2 infection. Background Concern exists that mild coronavirus disease 2019 may cause myocardial and vascular disease. Methods Participants were recruited from COVIDsortium, a 3-hospital prospective study of 731 health care workers who underwent first-wave weekly symptom, polymerase chain reaction, and serology assessment over 4 months, with seroconversion in 21.5% (n = 157). At 6 months post-infection, 74 seropositive and 75 age-, sex-, and ethnicity-matched seronegative control subjects were recruited for cardiovascular phenotyping (comprehensive phantom-calibrated cardiovascular magnetic resonance and blood biomarkers). Analysis was blinded, using objective artificial intelligence analytics where available. Results A total of 149 subjects (mean age 37 years, range 18 to 63 years, 58% women) were recruited. Seropositive infections had been mild with case definition, noncase definition, and asymptomatic disease in 45 (61%), 18 (24%), and 11 (15%), respectively, with 1 person hospitalized (for 2 days). Between seropositive and seronegative groups, there were no differences in cardiac structure (left ventricular volumes, mass, atrial area), function (ejection fraction, global longitudinal shortening, aortic distensibility), tissue characterization (T1, T2, extracellular volume fraction mapping, late gadolinium enhancement) or biomarkers (troponin, N-terminal pro–B-type natriuretic peptide). With abnormal defined by the 75 seronegatives (2 SDs from mean, e.g., ejection fraction 1,072 ms, septal T2 >52.4 ms), individuals had abnormalities including reduced ejection fraction (n = 2, minimum 50%), T1 elevation (n = 6), T2 elevation (n = 9), late gadolinium enhancement (n = 13, median 1%, max 5% of myocardium), biomarker elevation (borderline troponin elevation in 4; all N-terminal pro–B-type natriuretic peptide normal). These were distributed equally between seropositive and seronegative individuals. Conclusions Cardiovascular abnormalities are no more common in seropositive versus seronegative otherwise healthy, workforce representative individuals 6 months post–mild severe acute respiratory syndrome coronavirus 2 infection. Central Illustration |
| تدمد: | 1936-878X |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1de2633a653be4ba21755a6c54d615fbTest https://doi.org/10.1016/j.jcmg.2021.04.011Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....1de2633a653be4ba21755a6c54d615fb |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 1936878X |
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