التفاصيل البيبلوغرافية
| العنوان: |
Cobalt‐Catalyzed Enantioselective Synthesis of Chiral gem‐Bis(boryl)alkanes. |
| المؤلفون: |
Teo, Wei Jie1, Ge, Shaozhong1 chmgsh@nus.edu.sg |
| المصدر: |
Angewandte Chemie. 9/24/2018, Vol. 130 Issue 39, p13117-13121. 5p. |
| مصطلحات موضوعية: |
*COBALT, *ENANTIOSELECTIVE catalysis, *CHIRALITY, *ALKENES, *STEREOCHEMISTRY |
| الملخص (بالإنجليزية): |
We report an asymmetric synthesis of enantioenriched gem‐bis(boryl)alkanes in an enantioselective diborylation of 1,1‐disubstituted alkenes catalyzed by Co(acac)2/(R)‐DM‐segphos. A range of activated and unactivated alkenes underwent this asymmetric diborylation in the presence of cyclooctene as a hydrogen acceptor, affording the corresponding gem‐bis(boryl)alkanes with high enantioselectivity. The synthetic utility of these chiral organoboronate compounds was demonstrated through several stereospecific derivatizations and the synthesis of sesquiterpene and sesquiterpenoid natural products. [ABSTRACT FROM AUTHOR] |
| Abstract (German): |
Die Cobalt‐katalysierte asymmetrische Diborylierung gem‐disubstituierter Alkene ermöglicht die enantioselektive Synthese chiraler gem‐Bis(boryl)alkane. Der synthetische Nutzen der Produkte wurde durch stereospezifische Derivatisierungen und die Synthese von Sesquiterpen‐ und Sesquiterpenoid‐Naturstoffen demonstriert. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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