المؤلفون: Suzan Wetzels, Tim Vanmierlo, Jean L. J. M. Scheijen, Jack van Horssen, Sandra Amor, Veerle Somers, Casper G. Schalkwijk, Jerome J. A. Hendriks, Kristiaan Wouters

المصدر: Frontiers in Immunology, Vol 10 (2019)

مصطلحات موضوعية: multiple sclerosis, neuroinflammation, α-dicarbonyl, advanced glycation endproducts, astrocytes, Immunologic diseases. Allergy, RC581-607

وصف الملف: electronic resource

العلاقة: https://www.frontiersin.org/article/10.3389/fimmu.2019.00855/fullTest; https://doaj.org/toc/1664-3224Test

الوصول الحر: https://doaj.org/article/6af04ff8d6d1448cb3ea5e9686bbfb13Test

المؤلفون: Maarten E. Witte, John G.J.M. Bol, Wouter H. Gerritsen, Paul van der Valk, Benjamin Drukarch, Jack van Horssen, Micha M.M. Wilhelmus

المصدر: Neurobiology of Disease, Vol 36, Iss 3, Pp 445-452 (2009)

مصطلحات موضوعية: Alzheimer's disease, Astrocytes, Multiple sclerosis, Oxidative stress, Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571

وصف الملف: electronic resource

العلاقة: http://www.sciencedirect.com/science/article/pii/S0969996109002289Test; https://doaj.org/toc/1095-953XTest

الوصول الحر: https://doaj.org/article/8244a30411234e8d9bd05be5a1a288fbTest

المؤلفون: Jennifer Vandooren, Jack van Horssen, Ivo Lambrichts, Melissa Schepers, Chris Van den Haute, Ghislain Opdenakker, Helena Slaets, Wia Baron, Veerle Baekelandt, Niels Hellings, Tim Vanmierlo, Evelien Houben, Doryssa Hermans, Bieke Broux, Kris Janssens

المساهمون: Molecular cell biology and Immunology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Molecular Neuroscience and Ageing Research (MOLAR), Vandooren, Jennifer/0000-0002-7157-3370, Lambrichts, Ivo/0000-0001-7520-0021, Opdenakker, Ghislain/0000-0003-1714-2294, HOUBEN, Evelien, JANSSENS, Kris, HERMANS, Doryssa, Vandooren, Jennifer, Van den Haute, Chris, SCHEPERS, Melissa, VANMIERLO, Tim, LAMBRICHTS, Ivo, VAN HORSSEN, Jack, Baekelandt, Veerle, OPDENAKKER, Ghislain, Baron, Wia, BROUX, Bieke, Slaets, Helena, HELLINGS, Niels, Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience

المصدر: Proc Natl Acad Sci U S A
Proceedings of the National Academy of Sciences of the United States of America, 117(9), 5028-5038. National Academy of Sciences
Proceedings of the National Academy of Sciences of the United States of America, 117(9), 5028-5038. NATL ACAD SCIENCES
Houben, E, Janssens, K, Hermans, D, Vandooren, J, van den Haute, C, Schepers, M, Vanmierlo, T, Lambrichts, I, van Horssen, J, Baekelandt, V, Opdenakker, G, Baron, W, Broux, B, Slaets, H & Hellings, N 2020, ' Oncostatin M-induced astrocytic tissue inhibitor of metalloproteinases-1 drives remyelination ', Proceedings of the National Academy of Sciences of the United States of America, vol. 117, no. 9, pp. 5028-5038 . https://doi.org/10.1073/pnas.1912910117Test
Article

مصطلحات موضوعية: Central Nervous System, EXPRESSION, Multiple Sclerosis, Central nervous system, oligodendrocyte precursor cells, Matrix metalloproteinase, UP-REGULATION, PROTECTS, Myelin, Mice, Downregulation and upregulation, OLIGODENDROCYTE PROGENITOR CELLS, medicine, Animals, Humans, Remyelination, Demyelinating Disorder, Myelin Sheath, Mice, Knockout, Multidisciplinary, Tissue Inhibitor of Metalloproteinase-1, biology, RECEPTOR, business.industry, Interleukin-6, LIF, Multiple sclerosis, CENTRAL-NERVOUS-SYSTEM, Oncostatin M, astrocytes, MULTIPLE-SCLEROSIS, MEDIATED DEMYELINATION, Biological Sciences, medicine.disease, Axons, Cell biology, medicine.anatomical_structure, remyelination, biology.protein, CNS, business, tissue inhibitor of metalloproteinases-1, Demyelinating Diseases, oncostatin M

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7bf8b8166fe05f82c9125f02c7197a1Test
https://doi.org/10.1073/pnas.1912910117Test

المؤلفون: Philip Scheltens, Charlotte E. Teunissen, Victor L. Thijssen, Ananya Chakraborty, Ruud D. Fontijn, Alwin Kamermans, Ed Aanhane, Bert van het Hof, Jack van Horssen, Kitty C. M. Castricum, Wiesje M. van der Flier, Helga E. de Vries

المساهمون: Molecular cell biology and Immunology, Medical oncology laboratory, Radiation Oncology, Neurology, Clinical chemistry, Amsterdam Neuroscience - Neurovascular Disorders, APH - Personalized Medicine, APH - Methodology, Epidemiology and Data Science, ACS - Microcirculation

المصدر: Chakraborty, A, Kamermans, A, van Het Hof, B, Castricum, K, Aanhane, E, van Horssen, J, Thijssen, V L, Scheltens, P, Teunissen, C E, Fontijn, R D, van der Flier, W M & de Vries, H E 2018, ' Angiopoietin like-4 as a novel vascular mediator in capillary cerebral amyloid angiopathy ', Brain : a journal of neurology, vol. 141, no. 12, pp. 3377-3388 . https://doi.org/10.1093/brain/awy274Test
Brain : a journal of neurology, 141(12), 3377-3388

مصطلحات موضوعية: Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Angiopoietin-like 4 Protein, Vascular Remodeling, Blood–brain barrier, Vascular remodelling in the embryo, Angiopoietin, 03 medical and health sciences, 0302 clinical medicine, Cell Movement, Angiopoietin-Like Protein 4, Humans, Medicine, Vascular dementia, Aged, Aged, 80 and over, business.industry, Brain, Endothelial Cells, Human brain, medicine.disease, Cell Hypoxia, Endothelial stem cell, Cerebral Amyloid Angiopathy, 030104 developmental biology, medicine.anatomical_structure, Astrocytes, Microvessels, Female, Neurology (clinical), Cerebral amyloid angiopathy, business, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b850238bc9029d2faf99131bddf794dTest
https://doi.org/10.1093/brain/awy274Test

المؤلفون: Maarten E. Witte, Tom Verhoeven, Jasper J. Koning, Jack van Horssen, Bert van het Hof, Lauri Borghuis, Merel Rijnsburger, Alwin Kamermans, Helga E. de Vries

المساهمون: Molecular cell biology and Immunology, Amsterdam Neuroscience - Neuroinfection & -inflammation, ACS - Microcirculation

المصدر: Kamermans, A, Verhoeven, T, van het Hof, B, Koning, J J, Borghuis, L, Witte, M, van Horssen, J, de Vries, H E & Rijnsburger, M 2019, ' Setmelanotide, a Novel, Selective Melanocortin Receptor-4 Agonist Exerts Anti-inflammatory Actions in Astrocytes and Promotes an Anti-inflammatory Macrophage Phenotype ', Frontiers in Immunology, vol. 10, 2312 . https://doi.org/10.3389/fimmu.2019.02312Test
Frontiers in Immunology, 10:2312
Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Agonist, lcsh:Immunologic diseases. Allergy, medicine.drug_class, Immunology, Anti-Inflammatory Agents, macrophage, multiple sclerosis, Neuroprotection, 03 medical and health sciences, 0302 clinical medicine, astrocyte, Melanocortin receptor, medicine, Humans, Immunology and Allergy, melanocortin, Phosphorylation, Cyclic AMP Response Element-Binding Protein, Cells, Cultured, Original Research, Aged, melanocortin receptor-4, Interleukin-6, Chemistry, Macrophages, Neurodegeneration, Interleukin, Middle Aged, Interleukin-11, medicine.disease, Melanocortin 4 receptor, Phenotype, 030104 developmental biology, medicine.anatomical_structure, alpha-MSH, inflammation, Astrocytes, Cancer research, Receptor, Melanocortin, Type 4, Female, Melanocortin, lcsh:RC581-607, 030215 immunology, Astrocyte

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::896b17f5ae96d8db4852179819d9bb35Test
https://research.vumc.nl/en/publications/ca4f60ca-aecc-435f-9bd3-00a1d1002c6aTest

المؤلفون: Tim Vanmierlo, Sandra Amor, Suzan Wetzels, Kristiaan Wouters, Jerome J. A. Hendriks, Veerle Somers, Jean L.J.M. Scheijen, Casper G. Schalkwijk, Jack van Horssen

المساهمون: Molecular cell biology and Immunology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Pathology, AII - Inflammatory diseases, RS: CARIM - R3 - Vascular biology, Interne Geneeskunde, MUMC+: MA Alg Onderzoek Interne Geneeskunde (9), RS: CARIM - R3.01 - Vascular complications of diabetes and the metabolic syndrome, RS: MHeNs - R3 - Neuroscience, RS: Carim - B07 The vulnerable plaque: makers and markers, Pathologie, Psychiatrie & Neuropsychologie, RS: Carim - V01 Vascular complications of diabetes and metabolic syndrome

المصدر: Frontiers in Immunology, Vol 10 (2019)
Frontiers in Immunology
Frontiers in Immunology, 10
Frontiers in Immunology, 10:855. Frontiers Media S.A.
Wetzels, S, Vanmierlo, T, Scheijen, J L J M, van Horssen, J, Amor, S, Somers, V, Schalkwijk, C G, Hendriks, J J A & Wouters, K 2019, ' Methylglyoxal-Derived Advanced Glycation Endproducts Accumulate in Multiple Sclerosis Lesions ', Frontiers in Immunology, vol. 10, pp. 855 . https://doi.org/10.3389/fimmu.2019.00855Test

مصطلحات موضوعية: 0301 basic medicine, Glycation End Products, Advanced, Male, BIOMARKER, END-PRODUCTS AGES, multiple sclerosis, OXIDATION, DISEASE, RAGE (receptor), neuroinflammation, chemistry.chemical_compound, 0302 clinical medicine, Immunology and Allergy, Original Research, GENE-EXPRESSION, Microglia, Chemistry, Methylglyoxal, Middle Aged, Pyruvaldehyde, Immunohistochemistry, medicine.anatomical_structure, Disease Progression, Female, Disease Susceptibility, advanced glycation endproducts, lcsh:Immunologic diseases. Allergy, medicine.medical_specialty, alpha-dicarbonyl, astrocytes, Central nervous system, Immunology, MECHANISMS, 03 medical and health sciences, Immune system, CEREBROSPINAL-FLUID, Internal medicine, medicine, α-dicarbonyl, Humans, Neuroinflammation, Aged, Autoimmune disease, RECEPTOR, Multiple sclerosis, medicine.disease, INDIVIDUALS, 030104 developmental biology, Endocrinology, CHOROID-PLEXUS, lcsh:RC581-607, Biomarkers, 030215 immunology

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46bbb0a6c32d49bd865d71207d5160f7Test
https://cris.maastrichtuniversity.nl/en/publications/1a7ae3be-c424-419d-95d5-509a05bb113cTest

المؤلفون: Suzan Wetzels, Tim Vanmierlo, Jean L. J. M. Scheijen, Jack van Horssen, Sandra Amor, Veerle Somers, Casper G. Schalkwijk, Jerome J. A. Hendriks, Kristiaan Wouters

مصطلحات موضوعية: Immunology, Applied Immunology (incl. Antibody Engineering, Xenotransplantation and T-cell Therapies), Autoimmunity, Cellular Immunology, Humoural Immunology and Immunochemistry, Immunogenetics (incl. Genetic Immunology), Innate Immunity, Transplantation Immunology, Tumour Immunology, Immunology not elsewhere classified, Genetic Immunology, Animal Immunology, Veterinary Immunology, multiple sclerosis, neuroinflammation, α-dicarbonyl, advanced glycation endproducts, astrocytes

العلاقة: https://figshare.com/articles/figure/Image_2_Methylglyoxal-Derived_Advanced_Glycation_Endproducts_Accumulate_in_Multiple_Sclerosis_Lesions_TIF/8031854Test

الإتاحة: https://doi.org/10.3389/fimmu.2019.00855.s002Test
https://figshare.com/articles/figure/Image_2_Methylglyoxal-Derived_Advanced_Glycation_Endproducts_Accumulate_in_Multiple_Sclerosis_Lesions_TIF/8031854Test

المؤلفون: Jack van Horssen, Susanne M. A. van der Pol, Sandra Amor, Philip G. Nijland, Hervé Perron

المساهمون: Molecular cell biology and Immunology, Amsterdam Neuroscience - Neuroinfection & -inflammation, Pathology

المصدر: van Horssen, J, van der Pol, S, Nijland, P, Amor, S & Perron, H 2016, ' Human endogenous retrovirus W in brain lesions: Rationale for targeted therapy in multiple sclerosis ', Multiple Sclerosis and Related Disorders, vol. 8, pp. 11-18 . https://doi.org/10.1016/j.msard.2016.04.006Test
Multiple Sclerosis and Related Disorders, 8, 11-18. Elsevier

مصطلحات موضوعية: Adult, Male, 0301 basic medicine, Pathology, medicine.medical_specialty, Multiple Sclerosis, medicine.drug_class, viruses, Endogenous retrovirus, Monoclonal antibody, Lesion, 03 medical and health sciences, 0302 clinical medicine, Retrovirus, medicine, Humans, Aged, Aged, 80 and over, Microglia, biology, business.industry, Macrophages, Multiple sclerosis, Endogenous Retroviruses, Antibodies, Monoclonal, Brain, Gene Products, env, General Medicine, Middle Aged, medicine.disease, biology.organism_classification, Immunohistochemistry, 030104 developmental biology, medicine.anatomical_structure, Neurology, Astrocytes, Immunology, embryonic structures, Female, Neurology (clinical), medicine.symptom, business, 030217 neurology & neurosurgery, Astrocyte

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f9f9ccdb89b7f6eb1e274c1fcda3a4aTest

المؤلفون: Alwin Kamermans, Kees Jalink, Jack van Horssen, Helga E. de Vries, Kirsten E. Planting

المساهمون: Molecular cell biology and Immunology, Amsterdam Neuroscience - Neuroinfection & -inflammation, ACS - Microcirculation

المصدر: Glia
GLIA, 67(1), 68-77. John Wiley and Sons Inc.
Kamermans, A, Planting, K E, Jalink, K, van Horssen, J & de Vries, H E 2019, ' Reactive astrocytes in multiple sclerosis impair neuronal outgrowth through TRPM7-mediated chondroitin sulfate proteoglycan production ', GLIA, vol. 67, no. 1, pp. 68-77 . https://doi.org/10.1002/glia.23526Test

مصطلحات موضوعية: 0301 basic medicine, Adult, Male, Multiple Sclerosis, Central nervous system, chondroitin sulfate proteoglycan, TRPM7, TRPM Cation Channels, Biology, Protein Serine-Threonine Kinases, 03 medical and health sciences, Cellular and Molecular Neuroscience, chemistry.chemical_compound, Transient receptor potential channel, 0302 clinical medicine, Downregulation and upregulation, medicine, Animals, Humans, Cells, Cultured, Research Articles, Aged, Aged, 80 and over, Neurons, Multiple sclerosis, Neurodegeneration, astrocytes, neurodegeneration, Middle Aged, medicine.disease, In vitro, Cell biology, Rats, 030104 developmental biology, medicine.anatomical_structure, Neurology, chemistry, Chondroitin Sulfate Proteoglycans, Chondroitin sulfate proteoglycan, Female, 030217 neurology & neurosurgery, Research Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd28bb035a37c8aa45ffd980fc93a2fTest
https://pubmed.ncbi.nlm.nih.gov/30453391Test

المؤلفون: May H. Han, Paul L. Bollyky, Lawrence Steinman, Hedwich F. Kuipers, Jane Yoon, Jack van Horssen, Theo D. Palmer

المساهمون: Molecular cell biology and Immunology, Amsterdam Neuroscience - Neuroinfection & -inflammation

المصدر: Proceedings of the National Academy of Sciences of the United States of America, 114(9), E1745-E1754. National Academy of Sciences
Kuipers, H F, Yoon, J, Van Horssen, J, Han, M H, Bollyky, P L, Palmer, T D & Steinman, L 2017, ' Phosphorylation of αB-crystallin supports reactive astrogliosis in demyelination ', Proceedings of the National Academy of Sciences of the United States of America, vol. 114, no. 9, pp. E1745-E1754 . https://doi.org/10.1073/pnas.1621314114Test

مصطلحات موضوعية: 0301 basic medicine, Male, Encephalomyelitis, Autoimmune, Experimental, Multiple Sclerosis, Inflammation, Nerve Tissue Proteins, Biology, Pathogenesis, 03 medical and health sciences, Cuprizone, Mice, 0302 clinical medicine, Heat shock protein, medicine, Animals, Humans, Phosphorylation, Multidisciplinary, Multiple sclerosis, Experimental autoimmune encephalomyelitis, alpha-Crystallin B Chain, medicine.disease, Oligodendrocyte, Cell biology, Astrogliosis, Mice, Inbred C57BL, Disease Models, Animal, Oligodendroglia, 030104 developmental biology, medicine.anatomical_structure, PNAS Plus, Astrocytes, Female, medicine.symptom, Neuroscience, 030217 neurology & neurosurgery, Demyelinating Diseases

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd0bf6c59b80fdeff94bd67c2545fe73Test
https://research.vumc.nl/en/publications/cd02f09e-63fd-45af-94dd-2b4eaf916989Test