Inhibition of Allergic Bronchoconstriction in Guinea Pigs and in Asthmatics by the Leukotriene Antagonist ONO-1078
| العنوان: | Inhibition of Allergic Bronchoconstriction in Guinea Pigs and in Asthmatics by the Leukotriene Antagonist ONO-1078 |
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| المؤلفون: | Yutaka Mizushima, Y. Yui, F. Nambu, M. Motoishi, Akira Ishii, T. Nakagawa, Naohiro Yamashita, Terumasa Miyamoto, Koji Ito, Takao Shida |
| المصدر: | International Archives of Allergy and Immunology. 99:490-492 |
| بيانات النشر: | S. Karger AG, 1992. |
| سنة النشر: | 1992 |
| مصطلحات موضوعية: | Leukotriene, Leukotriene D4, business.industry, Leukotriene receptor, Immunology, Respiratory disease, Antagonist, General Medicine, respiratory system, medicine.disease, respiratory tract diseases, Guinea pig, chemistry.chemical_compound, chemistry, Immunology and Allergy, Medicine, Bronchoconstriction, medicine.symptom, business, Asthma |
| الوصف: | The effect of the leukotriene receptor antagonist ONO-1078 on experimental and clinical bronchial asthma was evaluated. It was found that this compound could inhibit antigen-induced bronchoconstriction in passively sensitized guinea pigs and leukotriene D4- and allergen-induced bronchial responses in normal and in asthmatic subjects. Clinical trials in patients with chronic bronchial asthma demonstrated its effectiveness in reducing hazardous symptoms like wheezing and dyspneic attacks. |
| تدمد: | 1423-0097 1018-2438 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b2f908664de021f7083796ac27c7a98dTest https://doi.org/10.1159/000236321Test |
| حقوق: | CLOSED |
| رقم الانضمام: | edsair.doi.dedup.....b2f908664de021f7083796ac27c7a98d |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14230097 10182438 |
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