دورية أكاديمية
A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis
| العنوان: | A common IL-13 Arg130Gln single nucleotide polymorphism among Chinese atopy patients with allergic rhinitis |
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| المؤلفون: | Wang, M, Xing, ZM, Lu, C, Ma, YX, Yu, DL, Yan, Z, Wang, SW, Yu, LS |
| المساهمون: | Yu, LS (reprint author), Peking Univ, Peoples Hosp, Dept ENT, 11 Xi Zhi Men Nan Da Jie, Beijing 100044, Peoples R China., Peking Univ, Peoples Hosp, Dept ENT, Beijing 100044, Peoples R China., Hosp Sick Children, Ctr Appl Genom, Toronto, ON M5G 1X8, Canada., Peking Univ, Peoples Hosp, Dept ENT, 11 Xi Zhi Men Nan Da Jie, Beijing 100044, Peoples R China. |
| المصدر: | SCI ; PubMed |
| بيانات النشر: | human genetics |
| سنة النشر: | 2003 |
| المجموعة: | Peking University Institutional Repository (PKU IR) / 北京大学机构知识库 |
| مصطلحات موضوعية: | INTERLEUKIN-13 GENE, CODING REGION, ASTHMA, ASSOCIATION, DERMATITIS, CHILDREN, VARIANT, LEVEL |
| الوصف: | Allergic rhinitis is a major public health problem and has seen its prevalence increase during the past few decades. Interleukin 13 (IL-13) has been implicated in the pathogenesis and in the regulation of immunoglobulin E (IgE) production. Single nucleotide polymorphisms (SNPs) have been found in both the coding sequence and the promoter region of IL-13, and such SNPs have been associated with allergic asthma. We have investigated whether IL-13 SNPs are associated with allergic rhinitis. Among 188 Chinese adult patients with allergic rhinitis and 87 normal controls, no significant difference was found in either allele or haplotype frequency of the SNPs between the two groups. Within patients, there was a significant association of the IL-13 Arg130Gln SNP, but not of the IL-13 promoter -1112(C/T) SNP, with serum total IgE levels. Patients with a Gln/Gln genotype showed much higher serum total IgE than those with an Arg/Arg genotype. When tested for serum-specific IgE, patients allergic to Derp 1, but not those allergic to Artemisia pollen, showed a significant association with the IL-13 promoter SNP. Thus, our results suggest a possible involvement of IL-13 SNPs in the regulation of IgE production in response to allergens in this Chinese population. ; Genetics & Heredity ; SCI(E) ; PubMed ; 0 ; ARTICLE ; 5 ; 387-390 ; 113 |
| نوع الوثيقة: | journal/newspaper |
| اللغة: | English |
| تدمد: | 0340-6717 |
| العلاقة: | HUMAN GENETICS.2003,113,(5),387-390.; 678842; http://hdl.handle.net/20.500.11897/200223Test; WOS:000185346700004 |
| DOI: | 10.1007/s00439-003-1001-x |
| الإتاحة: | https://doi.org/20.500.11897/200223Test https://doi.org/10.1007/s00439-003-1001-xTest https://hdl.handle.net/20.500.11897/200223Test |
| رقم الانضمام: | edsbas.929344A0 |
| قاعدة البيانات: | BASE |
| تدمد: | 03406717 |
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| DOI: | 10.1007/s00439-003-1001-x |