التفاصيل البيبلوغرافية
| العنوان: |
ROLE OF AMINOPHYLLINE IN PREVENTING RENAL DYSFUNCTION IN NEONATES WITH PERINATAL ASPHYXIA. |
| المؤلفون: |
Mehta, Sonal1, Sodhi, Manmeet Kaur2, Vipul3, Kaur, Navjot3, kaur, Kirandeep1 |
| المصدر: |
Journal of Cardiovascular Disease Research (Journal of Cardiovascular Disease Research). 2023, Vol. 14 Issue 7, p1530-1536. 7p. |
| مصطلحات موضوعية: |
*ASPHYXIA neonatorum, *KIDNEY diseases, *NEWBORN infants, *ACUTE kidney failure, *GLOMERULAR filtration rate, *NEONATAL mortality |
| مصطلحات جغرافية: |
AMRITSAR (India) |
| مستخلص: |
Background: Perinatal asphyxia is a common neonatal problem that contributes significantly to neonatal morbidity and mortality. Perinatal asphyxia is perceived to be the primary cause of transient renal dysfunction or acute renal failure. Adenosine plays an important role in tubuloglomerular feedback. Aminophylline is an adenosine receptor inhibitor, thus promotes renal perfusion and decreases solute load. Objectives: To study the role of aminophylline in preventing renal dysfunction in neonates with perinatal asphyxia. Methods: It is a prospective study with randomized control trials with cases and control group conducted over a period of one year in Department of Paediatrics, Govt. Medical College, Amritsar in collaboration with Department of Biochemistry. Renal functions were assessed on the basis of urine output, GFR and S. creatinine values on day1, 4 and 7. Results:Two comparable groups of cases and controls showed that there was a significant difference in urine output between the two groups on day 1(p=0.0003) and day4(p=0.000007). However, no such difference was found on day 7. Statically, no significant difference was found in values of glomerular filtration rate and S. creatinine values. Conclusion: Prophylactic use of aminophylline in neonates with perinatal asphyxia does not have significant impact in preventing AKI as there was no significant difference in S. creatinine values and GFR. There was no reduction in mortality rates in aminophylline treated group as compared to control group. [ABSTRACT FROM AUTHOR] |
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