نتائج البحث - "genetics [Membrane Proteins]"

1

Helical stability of the GnTV transmembrane domain impacts on SPPL3 dependent cleavage

المؤلفون: Alkmini A, Papadopoulou, Walter, Stelzer, Mara, Silber, Christine, Schlosser, Charlotte, Spitz, Martina, Haug-Kröper, Tobias, Straub, Stephan A, Müller, Stefan F, Lichtenthaler, Claudia, Muhle-Goll, Dieter, Langosch, Regina, Fluhrer

المصدر: Scientific Reports, 12 (1), Art.-Nr.: 20987
Scientific reports 12(1), 20987 (2022). doi:10.1038/s41598-022-24772-8

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d045c596e352ffd9b2b25e9120ca7b91Test
https://doi.org/10.1038/s41598-022-24772-8Test

2

The β-Secretase Substrate Seizure 6-Like Protein (SEZ6L) Controls Motor Functions in Mice

المؤلفون: Emma Ong-Pålsson, Jasenka Rudan Njavro, Yvette Wilson, Martina Pigoni, Andree Schmidt, Stephan A. Müller, Michael Meyer, Jana Hartmann, Marc Aurel Busche, Jenny M. Gunnersen, Kathryn M. Munro, Stefan F. Lichtenthaler

المصدر: Molecular neurobiology 59(2), 1183-1198 (2022). doi:10.1007/s12035-021-02660-y

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa386019a5cc6178d4c136884ad54dafTest
https://mediatum.ub.tum.de/1704966Test

3

Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis

المؤلفون: Björn Rabe, Torben Mentrup, Florencia Cabrera-Cabrera, Ann-Christine Gradtke, Akio Fukumori, Kosta Theodorou, Regina Fluhrer, Andreas Tholey, Marjo M. P. C. Donners, Kathrin Happ, Marion J.J. Gijbels, Andreas O. Helbig, Harald Steiner, Bernd Schröder

المساهمون: RS: CARIM - R3 - Vascular biology, Pathologie, Moleculaire Genetica, RS: Carim - B07 The vulnerable plaque: makers and markers, Medical Biochemistry, ACS - Atherosclerosis & ischemic syndromes, AII - Inflammatory diseases

المصدر: Journal of Experimental Medicine, 216(4), 807-830. Rockefeller University Press
Journal of experimental medicine 216(4), 807-830 (2019). doi:10.1084/jem.20171438
Journal of experimental medicine, 216(4), 807-830. Rockefeller University Press
The Journal of Experimental Medicine

مصطلحات موضوعية: 0301 basic medicine, medicine.medical_treatment, NF-KAPPA-B, TISSUE GROWTH-FACTOR, NUCLEAR TRANSLOCATION, 030204 cardiovascular system & hematology, PROTEASE SPPL2A, ADAM10 Protein, Mice, 0302 clinical medicine, metabolism [Scavenger Receptors, Class E], Aspartic Acid Endopeptidases, Immunology and Allergy, metabolism [Atherosclerosis], Receptor, Research Articles, OXIDIZED LDL RECEPTOR-1, Mice, Knockout, integumentary system, Kinase, Chemistry, Dipeptides, OX-LDL, antagonists & inhibitors [Aspartic Acid Endopeptidases], metabolism [Aspartic Acid Endopeptidases], Scavenger Receptors, Class E, Cell biology, Transmembrane domain, genetics [Membrane Proteins], Ectodomain, metabolism [ADAM10 Protein], lipids (amino acids, peptides, and proteins), pharmacology [Dipeptides], Signal peptide, Proteases, Immunology, LOW-DENSITY-LIPOPROTEIN, Transfection, PEPTIDASE-LIKE 2A, DENDRITIC CELLS, Article, 03 medical and health sciences, metabolism [Endothelial Cells], medicine, Animals, Humans, genetics [Scavenger Receptors, Class E], ddc:610, PROMOTES ATHEROSCLEROSIS, Growth factor, Endothelial Cells, Membrane Proteins, Atherosclerosis, metabolism [Amyloid Precursor Protein Secretases], CTGF, Mice, Inbred C57BL, 030104 developmental biology, HEK293 Cells, genetics [Aspartic Acid Endopeptidases], Proteolysis, Amyloid Precursor Protein Secretases, metabolism [Membrane Proteins], HeLa Cells

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ffa6a4d6e22e67e518e3fac901144feTest
https://cris.maastrichtuniversity.nl/en/publications/cee764c5-af8e-4b98-b7d7-845e25dbe728Test

4

Signal peptide peptidase and SPP-like proteases: possible therapeutic targets?

المؤلفون: Bernd Schröder, Regina Fluhrer, Ann-Christine Loock, Torben Mentrup

المصدر: Biochimica et biophysica acta / Molecular cell research 1864(11), 2169-2182 (2017). doi:10.1016/j.bbamcr.2017.06.007

مصطلحات موضوعية: 0301 basic medicine, Proteases, Proteolysis, genetics [Amyloid Precursor Protein Secretases], antagonists & inhibitors [Amyloid Precursor Protein Secretases], Biology, Endoplasmic-reticulum-associated protein degradation, medicine.disease_cause, dermcidin, Substrate Specificity, Autoimmunity, antagonists & inhibitors [Membrane Proteins], 03 medical and health sciences, genetics [Peptides], ddc:570, medicine, SPPL2B, metabolism [Peptides], Aspartic Acid Endopeptidases, Humans, Amino Acid Sequence, γ secretase, ddc:610, antagonists & inhibitors [Peptides], Molecular Biology, medicine.diagnostic_test, genetics [Amino Acid Sequence], SPPL2b protein, human, Membrane Proteins, Cell Biology, antagonists & inhibitors [Aspartic Acid Endopeptidases], genetics [Membrane Proteins], 030104 developmental biology, Biochemistry, genetics [Aspartic Acid Endopeptidases], SPPL2a protein, human, Amyloid Precursor Protein Secretases, Peptides, Signal peptide peptidase, Intramembrane Proteolysis

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8959e573870c1ccbcaad6b2fcb47798aTest
https://opus.bibliothek.uni-augsburg.de/opus4/frontdoor/index/index/docId/51762Test

5

Constitutive α- and β-secretase cleavages of the amyloid precursor protein are partially coupled in neurons, but not in frequently used cell lines

المؤلفون: Peter J. Dempsey, Alessio Colombo, Huanhuan Wang, Howard C. Crawford, Richard M. Page, Stefan F. Lichtenthaler, Peer-Hendrik Kuhn, Elisabeth Kremmer

المصدر: Neurobiology of Disease, Vol 49, Iss, Pp 137-147 (2013)
Neurobiology of disease 49, 137-147 (2013). doi:10.1016/j.nbd.2012.08.011

مصطلحات موضوعية: ADAM10, genetics [Amyloid Precursor Protein Secretases], genetics [ADAM Proteins], antagonists & inhibitors [Amyloid Precursor Protein Secretases], APP protein, human, drug effects [Cerebral Cortex], antagonists & inhibitors [Membrane Proteins], ADAM10 Protein, Amyloid beta-Protein Precursor, enzymology [Cerebral Cortex], metabolism [Amyloid beta-Protein Precursor], Adam10 protein, mouse, Amyloid precursor protein, Aspartic Acid Endopeptidases, Cells, Cultured, Cerebral Cortex, Mice, Knockout, Neurons, enzymology [Neurons], biology, Beta-secretase, P3 peptide, antagonists & inhibitors [Aspartic Acid Endopeptidases], metabolism [Aspartic Acid Endopeptidases], Alzheimer's disease, Cell biology, genetics [Membrane Proteins], Neurology, Biochemistry, Alpha secretase, Gene Knockdown Techniques, pharmacology [Protease Inhibitors], antagonists & inhibitors [ADAM Proteins], Proteases, Bace1 protein, mouse, ADAM10 protein, human, Cleavage (embryo), Article, lcsh:RC321-571, ddc:570, BACE1 protein, human, Cell Line, Tumor, mental disorders, drug effects [Neurons], Animals, Humans, Protease Inhibitors, lcsh:Neurosciences. Biological psychiatry. Neuropsychiatry, HEK 293 cells, Membrane Proteins, metabolism [Amyloid Precursor Protein Secretases], ADAM Proteins, HEK293 Cells, genetics [Aspartic Acid Endopeptidases], metabolism [ADAM Proteins], biology.protein, Alpha-secretase, Amyloid Precursor Protein Secretases, Amyloid precursor protein secretase, metabolism [Membrane Proteins]

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::70a210b18f7776118cd99ac65dfe680fTest
http://www.sciencedirect.com/science/article/pii/S0969996112002987Test

6

Substrate determinants of signal peptide peptidase-like 2a (SPPL2a)-mediated intramembrane proteolysis of the invariant chain CD74

المؤلفون: Harald Steiner, Regina Fluhrer, Paul Saftig, Felix Helfrich, Sebastian Held, Akio Fukumori, Bernd Schröder, Susann Hüttl, Torben Mentrup

المصدر: Biochemical journal 473(10), 1405-1422 (2016). doi:10.1042/BCJ20160156

مصطلحات موضوعية: 0301 basic medicine, Signal peptide, genetics [Antigens, Differentiation, B-Lymphocyte], Endosome, Intramembrane protease, medicine.medical_treatment, Proteolysis, SPPL2a protein, mouse, Cleavage (embryo), Biochemistry, invariant chain, 03 medical and health sciences, Mice, chemistry [Histocompatibility Antigens Class II], Cell Line, Tumor, medicine, chemistry [Antigens, Differentiation, B-Lymphocyte], Animals, Aspartic Acid Endopeptidases, Humans, ddc:610, Fluorescent Antibody Technique, Indirect, Molecular Biology, Mice, Knockout, Protease, medicine.diagnostic_test, biology, Histocompatibility Antigens Class II, Membrane Proteins, Cell Biology, metabolism [Aspartic Acid Endopeptidases], Transmembrane protein, Cell biology, Antigens, Differentiation, B-Lymphocyte, genetics [Membrane Proteins], Transmembrane domain, 030104 developmental biology, metabolism [Antigens, Differentiation, B-Lymphocyte], genetics [Aspartic Acid Endopeptidases], SPPL2a protein, human, ddc:540, signal peptide peptidase, biology.protein, metabolism [Histocompatibility Antigens Class II], metabolism [Membrane Proteins], genetics [Histocompatibility Antigens Class II]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e01c29a9a095fa4d01defcb57e6e8828Test
https://pubmed.ncbi.nlm.nih.gov/26987812Test

7

The intramembrane proteases signal Peptide peptidase-like 2a and 2b have distinct functions in vivo

المؤلفون: Bernd Schröder, Susann Hüttl, Jürgen Wienands, Kai Dittmann, Ralf Dressel, Michelle Rothaug, Paul Saftig, Michael Engelke, Regina Fluhrer, Torben Mentrup, Janna Schneppenheim, Masatake Araki, Kimi Araki, Renate Lüllmann-Rauch

المصدر: Molecular and cellular biology 34(8), 1398-1411 (2014). doi:10.1128/MCB.00038-14

مصطلحات موضوعية: Signal peptide, Proteases, Proteolysis, medicine.medical_treatment, SPPL2a protein, mouse, Biology, invariant chain, 03 medical and health sciences, Mice, ddc:570, metabolism [Dendritic Cells], SPPL2B, medicine, Animals, Aspartic Acid Endopeptidases, ddc:610, SPPL2b protein, mouse, metabolism [B-Lymphocytes], Molecular Biology, B cell, 030304 developmental biology, Mice, Knockout, B-Lymphocytes, 0303 health sciences, Protease, medicine.diagnostic_test, 030302 biochemistry & molecular biology, Histocompatibility Antigens Class II, Brain, Membrane Proteins, Articles, Dendritic Cells, Cell Biology, metabolism [Aspartic Acid Endopeptidases], Antigens, Differentiation, B-Lymphocyte, Dendritic cell homeostasis, genetics [Membrane Proteins], medicine.anatomical_structure, Biochemistry, metabolism [Antigens, Differentiation, B-Lymphocyte], genetics [Aspartic Acid Endopeptidases], metabolism [Brain], signal peptide peptidase, Heterologous expression, metabolism [Histocompatibility Antigens Class II], metabolism [Membrane Proteins]

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::290f81def68c61c187030a7631e89458Test

8

The intramembrane protease SPPL2a promotes B cell development and controls endosomal traffic by cleavage of the invariant chain

المؤلفون: Eeva-Liisa Eskelinen, Jürgen Wienands, Paul Saftig, Renate Lüllmann-Rauch, Michael Engelke, Kai Dittmann, Ralf Dressel, Bernd Schröder, Susann Hüttl, Regina Fluhrer, Irm Hermans-Borgmeyer, Janna Schneppenheim

المساهمون: Biosciences, Autophagy

المصدر: Journal of experimental medicine 210(1), 41-58 (2012). doi:10.1084/jem.20121069
Journal of Experimental Medicine; Vol 210
The Journal of Experimental Medicine

مصطلحات موضوعية: Endocytic cycle, physiology [B-Lymphocytes], SPPL2a protein, mouse, Mice, 0302 clinical medicine, metabolism [B-Lymphocyte Subsets], Immunology and Allergy, metabolism [Peptide Fragments], Aspartic Acid Endopeptidases, genetics [Cell Survival], Cells, Cultured, B-Lymphocytes, 0303 health sciences, biology, immunology [B-Lymphocytes], metabolism [Aspartic Acid Endopeptidases], Cell biology, genetics [B-Cell Activation Factor Receptor], genetics [Membrane Proteins], Protein Transport, medicine.anatomical_structure, pathology [B-Lymphocytes], metabolism [Antigens, Differentiation, B-Lymphocyte], genetics [Immunity, Humoral], metabolism [Endosomes], genetics [Antigens, Differentiation, B-Lymphocyte], Cell Survival, Endosome, Intramembrane protease, Immunology, B-cell receptor, Molecular Sequence Data, education, B-Lymphocyte Subsets, Endosomes, ultrastructure [B-Lymphocytes], Regulated Intramembrane Proteolysis, Article, Presenilin, metabolism [B-Cell Activation Factor Receptor], invariant chain, 03 medical and health sciences, medicine, Animals, Humans, ddc:610, B cell, 030304 developmental biology, metabolism [Vacuoles], Base Sequence, Histocompatibility Antigens Class II, Membrane Proteins, Tnfrsf13c protein, mouse, Mice, Mutant Strains, Peptide Fragments, Immunity, Humoral, Mice, Inbred C57BL, Antigens, Differentiation, B-Lymphocyte, genetics [Aspartic Acid Endopeptidases], Vacuoles, biology.protein, 1182 Biochemistry, cell and molecular biology, metabolism [Histocompatibility Antigens Class II], Cytokinesis, metabolism [Membrane Proteins], 030215 immunology, genetics [Histocompatibility Antigens Class II], B-Cell Activation Factor Receptor