Epidemiology of hepatitis C virus infectionliver disease among injection drug users (IDUs) in Chennai, India
| العنوان: | Epidemiology of hepatitis C virus infectionliver disease among injection drug users (IDUs) in Chennai, India |
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| المؤلفون: | Shruti H, Mehta, Samantha L, Vogt, Aylur K, Srikrishnan, Conjeevaram K, Vasudevan, Kalilapuri G, Murugavel, Shanmugam, Saravanan, Santhanam, Anand, M Suresh, Kumar, Stuart C, Ray, David D, Celentano, Suniti, Solomon, Sunil S, Solomon |
| المصدر: | The Indian Journal of Medical Research |
| سنة النشر: | 2011 |
| مصطلحات موضوعية: | Adult, Blood Platelets, Liver Cirrhosis, Male, hepatitis C virus, Genotype, India, Hepacivirus, Antibodies, Viral, Statistics, Nonparametric, Cohort Studies, Drug Users, Prevalence, Humans, Aspartate Aminotransferases, Prospective Studies, APRI, injection drug users, virus diseases, HIV, Hepatitis C, digestive system diseases, HCV genotype, RNA, Viral, Original Article, liver disease |
| الوصف: | Background & Objectives: We characterized HCV antibody prevalence, viral persistence, genotype and liver disease prevalence among IDUs in Chennai, India as the study of the association of HIV with each of these states is important and there are no data available. Methods: Between 2005-2006, 1158 IDUs were recruited and followed semi-annually. All were tested for HCV antibodies at baseline; a random sample of 400 antibody positives (200 HIV-positive and 200 HIV-negative) were tested for HCV RNA; 13 of these were sequenced. Assessment of asparate amino transferase (AST)-to-platelet ratio index (APRI) was done on 557 IDUs. Prevalence ratios of each outcome were examined. Results: Median age was 35 yr; 99 per cent were male. HCV antibody prevalence was 55 per cent and was associated with older age, being unmarried, longer injection history, tattoo and injecting at a dealer’s place. Of the 400 HCV antibody positive IDUs, 281 (70.3%) had persistent infection which was less common among hepatitis B-infected persons but not associated with HIV. Of the 13 samples sequenced, 11 (85%) were HCV genotype 3a. Fibrosis prevalence according to APRI was: HIV/HCV-uninfected, 4 per cent; HIV mono-infected, 3 per cent; HCV mono-infected, 11 per cent; HIV/HCV co-infected, 12 per cent (P |
| تدمد: | 0971-5916 2005-2006 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=pmid________::c6a6ddeebcfaff0ce95b51f54d7a5363Test https://pubmed.ncbi.nlm.nih.gov/21245619Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.pmid..........c6a6ddeebcfaff0ce95b51f54d7a5363 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 09715916 20052006 |
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