المؤلفون: Selin Demirer, Meryem Hocaoglu, Evrim Komurcu-Bayrak, Abdulkadir Turgut, Ateş Karateke

المصدر: Pregnancy Hypertension. 19:239-245

مصطلحات موضوعية: Adult, Systole, 030204 cardiovascular system & hematology, Real-Time Polymerase Chain Reaction, Body Mass Index, Preeclampsia, Pathogenesis, Andrology, Leukocyte Count, 03 medical and health sciences, 0302 clinical medicine, Pre-Eclampsia, Pregnancy, Leukocytes, Internal Medicine, Humans, Medicine, Aspartate Aminotransferases, Circulating MicroRNA, Prospective Studies, 030219 obstetrics & reproductive medicine, L-Lactate Dehydrogenase, Receiver operating characteristic, Platelet Count, business.industry, Obstetrics and Gynecology, Gestational age, Alanine Transaminase, medicine.disease, Up-Regulation, Blood pressure, Real-time polymerase chain reaction, Case-Control Studies, Biomarker (medicine), Female, business, Body mass index

الوصف: Maternal leucocytes play an important role in the pathogenesis of preeclampsia (PE). Circulating microRNAs (miRNAs) are small, noncoding RNA molecules. The purpose of this study was to investigate miR-518b, miR-155-5p, and miR-21-3p in the peripheral blood leukocytes of patients with PE, compared to controls.Using real-time quantitative PCR method, the selected miRNAs which have been associated with PE were examined from early- onset PE (EOPE) (34 weeks) (n = 48), late- onset PE (LOPE) (≥34 weeks) (n = 48), total cases of PE (n = 96), and healthy controls (n = 52).The relative expression of the target miR in patient samples was compared to the calibrator and the results were expressed as relative quantification values.Gestational age (GA) was significantly different between PE and controls. Univariate logistic regression analysis adjusted for GA at blood draw were fit to compare miR-518b, miR-155-5p, and miR-21-3p between PE and controls. The expression of miR-518b, miR-155-5p, and miR-21-3p were not significantly different in PE, compared to controls. The expression of miR-518b was upregulated in the EOPE and LOPE group, compared to controls, and the area under the receiver operating characteristic curve (AUC) of miR-518b was 0.65 and 0.62, respectively. miR-518b was positively correlated with WBC count, platelet count, serum levels of AST, ALT, LDH in EOPE. miR-21-3p expression level was negatively correlated with body mass index at blood draw and systolic blood pressure in the LOPE group.Increased miR-518b expression levels were found to be associated with EOPE and LOPE.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aee2a8c5cdb6f0c7b1a54edfb91a9801Test
https://doi.org/10.1016/j.preghy.2019.11.003Test

المؤلفون: Xia Huang, Dan Li, Feng Liu, Yifan Zhu, Deyu Zhao, Heng Tang

المصدر: BMC Infectious Diseases, Vol 21, Iss 1, Pp 1-8 (2021)
BMC Infectious Diseases

مصطلحات موضوعية: Male, Neutrophils, Pleural effusion, 030204 cardiovascular system & hematology, Gastroenterology, Leukocyte Count, chemistry.chemical_compound, 0302 clinical medicine, Risk Factors, 030212 general & internal medicine, Child, Liver injury, medicine.diagnostic_test, biology, Alanine Transaminase, C-Reactive Protein, Infectious Diseases, medicine.anatomical_structure, Child, Preschool, Erythrocyte sedimentation rate, Female, Research Article, medicine.medical_specialty, Blood Sedimentation, lcsh:Infectious and parasitic diseases, Fibrin Fibrinogen Degradation Products, 03 medical and health sciences, White blood cell, Internal medicine, Lactate dehydrogenase, Pneumonia, Mycoplasma, D-dimer, medicine, Humans, lcsh:RC109-216, Clinical significance, Aspartate Aminotransferases, Retrospective Studies, L-Lactate Dehydrogenase, business.industry, Refractory Mycoplasma pneumoniae pneumonia, medicine.disease, Mycoplasma pneumoniae, Pleural Effusion, Logistic Models, Alanine transaminase, chemistry, biology.protein, business

الوصف: Background The levels of serum D-dimer (D-D) in children with Mycoplasma pneumoniae pneumonia (MPP) were assessed to explore the clinical significance of D-D levels in refractory MPP (RMPP). Method A total of 430 patients with MPP were enrolled between January 2015 and December 2015 and divided into a general MPP (GMPP) group (n = 306) and a RMPP group (n = 124). Clinical data, D-D level, white blood cell (WBC) count, proportion of neutrophils (N%), C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), alanine transaminase (ALT), aspartate aminotransferase (AST), and lactate dehydrogenase (LDH) were compared between the two groups. Multivariate logistic regression was performed to identify independent predictors of RMPP. Results (1) Hospitalization time, preadmission fever duration, total fever duration, WBC, N %, CRP, LDH, ESR, ALT, AST, and D-D were significantly higher in the RMPP group than those in the GMPP group (all P P P P Conclusion Serum D-D levels were significantly increased in patients with RMPP, indicating that excessive inflammatory response and vascular endothelial injury with prolonged duration existed in this patient population. Increased levels of serum D-D may be used as an early predictor of RMPP and the occurrence of complications. Our findings provide a theoretical basis for the early diagnosis of RMPP, early intervention and excessive inflammatory response in the pathogenesis of mycoplasma.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4becf1a59c4ed65aad4e4e41ca23a32dTest
https://doi.org/10.1186/s12879-020-05700-5Test

المؤلفون: Ching-Hui Sia, Jinghao Nicholas Ngiam, Shuyun Cen, Sai Meng Tham, Tony Y.W. Li, Mark D. Muthiah, Zhen Yu Lim, Paul A. Tambyah, Gail B Cross, Amelia Santosa, Nicholas Chew

المصدر: Medicine

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, medicine.medical_treatment, Aspartate transaminase, Observational Study, Gastroenterology, chemistry.chemical_compound, Liver disease, coronavirus disease 2019, Leukocyte Count, Liver Function Tests, Risk Factors, Lactate dehydrogenase, Intensive care, Internal medicine, medicine, transaminitis, Humans, Aspartate Aminotransferases, Retrospective Studies, Mechanical ventilation, Singapore, biology, medicine.diagnostic_test, L-Lactate Dehydrogenase, business.industry, Liver Diseases, COVID-19, General Medicine, Middle Aged, medicine.disease, Pneumonia, chemistry, Ferritins, biology.protein, Abnormal Liver Function Test, Female, business, Liver function tests, Research Article

الوصف: Liver dysfunction in patients with COVID-19 (coronavirus disease 2019) has been described. However, it is not clear if the presence of abnormal liver function tests at presentation was related to underlying undiagnosed liver disease, or a result of the viral infection.We retrospectively examined the first 554 consecutive polymerase chain reaction positive SARS-CoV-2 patients admitted from February 2020 to April 2020 to our academic medical centre. We reviewed their clinical data, chest radiography and laboratory studies obtained within 24 hour of admission.Despite similar hemodynamic parameters, we found significant aspartate transaminase elevation (64 ±â€Š141 vs 35 ±â€Š23 U/L, P 

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208bdb4cdbdfb567faf72c169288b992Test
https://pubmed.ncbi.nlm.nih.gov/34397705Test

المؤلفون: William E. Lee, Leon Arriola, Aditi Ghosh, Claire Onsager, Anuj Mubayi, Andrew Mason

المصدر: PLoS ONE, Vol 16, Iss 4, p e0230833 (2021)
PLoS ONE

مصطلحات موضوعية: Necrosis, Physiology, Biochemistry, Gastroenterology, Hepatitis, chemistry.chemical_compound, Ischemia, Animal Cells, Medicine and Health Sciences, Hypoxia, Liver injury, Multidisciplinary, Cell Death, biology, Liver Diseases, Liver cell, Alanine Transaminase, Body Fluids, Chemistry, Blood, Liver, Cell Processes, Physical Sciences, Medicine, medicine.symptom, Cellular Types, Anatomy, Research Article, Chemical Elements, medicine.medical_specialty, Science, Aspartate transaminase, Surgical and Invasive Medical Procedures, Models, Biological, Necrotic Cell Death, Digestive System Procedures, Signs and Symptoms, Internal medicine, Lactate dehydrogenase, medicine, Humans, Aspartate Aminotransferases, Transplantation, L-Lactate Dehydrogenase, Septic shock, business.industry, Biology and Life Sciences, Cell Biology, Organ Transplantation, medicine.disease, Liver Transplantation, Oxygen, Respiratory failure, Alanine transaminase, chemistry, Heart failure, Reperfusion, Hepatocytes, biology.protein, Clinical Medicine, Physiological Processes, business, Biomarkers

الوصف: Ischaemic Hepatitis (IH) or Hypoxic Hepatitis (HH) also known as centrilobular liver cell necrosis is an acute liver injury characterized by a rapid increase in serum aminotransferase. The liver injury typically results from another underlying medical conditions like cardiac failure, respiratory failure and septic shock in which the liver becomes damaged due to deprivation of either blood or oxygen. IH is a potentially lethal condition which is often preventable if diagnosed properly. {\em Unfortunately, mechanism that causes IH are often not well understood, making it difficult to diagnose or accurately quantify the patterns of related biomarkers}. In most cases, currently the only way to determine a case of IH (i.e., to diagnose it) is to rule out all other possible conditions for other liver injuries. A better understanding of the liver9s response to IH is necessary to aid in its diagnosis, measurement and improve outcomes. {\bf The goal of this study, is to identify mechanisms that can alter a few associated biomarkers for reducing density of damaged hepatocytes, and thus reduce chances of IH}. To this end, we develop a mathematical model capturing dynamics of hepatocytes in the liver through the rise and fall of associated liver enzymes aspartate transaminase (AST), alanine transaminase (ALT) and lactate dehydrogenase (LDH) related to condition of IH. %It studies liver cell death in response to IH caused by chronic heart failure and cardiovascular shock. The model analysis provides a novel approach to predict the level of biomarkers given variations in the systemic oxygen in the body. Using IH patient data in US, novel model parameters are described and then estimated for the first time to capture real time dynamics of hepatocytes in the presence and absence of IH condition. Different scenarios of patient conditions were also analyzed and validated using empirical information. This study and its results may allow physicians to estimate the extent of liver damage in a IH patient based on their enzyme levels and receive faster treatment on real time basis.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ce23f3c0d188b2796b122d18fd1dbadTest
https://doaj.org/article/c00d60df954545f9906b8cb76b27e778Test

المؤلفون: Antonio Vicente Mundim, Luiz Carlos de Abreu, Zhang Zhiguo, Nilson Penha-Silva, Fredy D. Guerra, Vitor Engrácia Valenti, Guilherme Gularte de Agostini, Alexandre Vilaça, Isabel Cristina Esposito Sorpreso, Romeu Paulo Martins Silva

المساهمون: Federal University of Acre Gleba Formoso, University Center of the Araxá Plateau, Universidade Federal de Uberlândia (UFU), School of Medicine Od ABC, Changzhou University, Universidade de São Paulo (USP), Universidade Estadual Paulista (Unesp)

المصدر: Scopus
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP

مصطلحات موضوعية: Male, haematocrit, blood chemical analysis, medicine.medical_specialty, Lymphocyte, Running, chemistry.chemical_compound, stress, physiological, Stress, Physiological, Internal medicine, Lactate dehydrogenase, medicine, Humans, Orthopedics and Sports Medicine, Aspartate Aminotransferases, Prospective Studies, hydrocortisone, Prospective cohort study, Creatine Kinase, Hydrocortisone, exercise, biology, Athletes, business.industry, Monocyte, Alanine Transaminase, Eosinophil, biology.organism_classification, medicine.anatomical_structure, Endocrinology, chemistry, biology.protein, Female, Creatine kinase, blood cells, business, Biomarkers, medicine.drug

الوصف: In order to provide additional information on the behaviour of biochemical parameters related to stress responses to a specific long-term competition, we aimed to compare the stressful effects of a long-lasting competition on physiological variables in men and women. This is a prospective observational analytical study. Twenty-five professional athletes, 15 men and 10 women, travelled 460 km for 4 days in an international edition of the Ecomotion/Pro AR World. After the competition, we detected an increase in α-amylase and cortisol levels and a decrease in salivary immunoglobulin A (lgA) levels. The relative percentage changes in α-amylase, IgA and cortisol levels were significantly higher in women than in men, whereas women had lower relative percentage changes in glucose and lactate levels compared with men. There was a decrease in lymphocyte, eosinophil and monocyte counts, with relative percentage decreases in lymphocytes and monocytes being significantly higher in female athletes than in males. There were increases in the serum activities of total creatine kinase (CK), the creatine kinase myocardial isoform (CKMB), alanine aminotransferase (ALT), aspartate aminotransferase (AST) and lactate dehydrogenase (LDH) at the end of the test, with significantly higher elevations of total CK, CKMB and LDH in men and ALT in women. Long-lasting competition induced stress, muscle damage, anaemia and changes in the immune system. Women had more intense responses of cortisol and leukocytes. Um zusätzliche Informationen zum Verhalten biochemischer Parameter in Verbindung mit stressbedingten Reaktionen auf einen speziellen Langstreckenwettkampf zu gewinnen, verglichen wir die stressbedingten Auswirkungen eines Langstreckenwettkampfs auf physiologische Variablen bei Männern und Frauen. Bei dieser Studie handelt es sich um eine prospektive Beobachtungsanalyse. 25 Profisportler (15 Männer und 10 Frauen) legten in einer internationalen Ausgabe der Ecomotion/Pro AR World in 4 Tagen 460 km zurück. Nach dem Wettkampf fanden sich erhöhte α-Amylase- und Kortisolspiegel sowie eine Abnahme der Immunglobulin-A(IgA)-Spiegel im Speichel. Die relativen prozentualen Veränderungen der α-Amylase-, IgA- und Kortisolspiegel waren bei Frauen signifikant höher als bei Männern. Frauen wiesen geringere relative Veränderungen der Glukose- und Laktatwerte auf als Männer. Es zeigte sich eine Abnahme der Lymphozyten-, Eosinophilen- und Monozytenzahlen, wobei die relative prozentuale Abnahme der Lymphozyten und Monozyten bei weiblichen Athleten signifikant höher ausfiel als bei männlichen. Am Ende des Tests wurden signifikant höhere Serumaktivitäten der Gesamtkreatinkinase (CK), der Kreatinkinase-Myokard-Isoform (CKMB), der Alanin-Aminotransferase (ALT), der Aspartat-Aminotransferase (AST) und der Laktatdehydrogenase (LDH) gemessen. Hierbei wiesen die Männer eine signifikant höhere Zunahme der Gesamt-CK-, CKMB- und LDH-Werte auf, während bei den Frauen der ALT-Wert signifikant stärker erhöht war. Der Langzeitwettkampf führte zu Stress, Muskelschäden, Blutarmut und Veränderungen im Immunsystem. Frauen zeigten intensivere Reaktionen bei den Kortisol- und Leukozytenwerten.

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::349497df2b5f936411e9a6fc3b1fd559Test
https://doi.org/10.1055/a-0928-0990Test

المؤلفون: Paulo N. Martins, Natasha H. Dolgin, Paria Mahboub, Babak Movahedi, Isabel M A Brüggenwirth, Adel Bozorgzadeh, Ann-Britt Martins, Amanda Rawson

المصدر: Experimental and clinical transplantation, 17(4), 498-506

مصطلحات موضوعية: Adult, Male, medicine.medical_specialty, Time Factors, Bilirubin, 030230 surgery, Single Center, Gastroenterology, Donor Selection, Hepatitis, Transaminase, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Liver Function Tests, Predictive Value of Tests, Risk Factors, Statistical significance, Lactate dehydrogenase, Internal medicine, Quantitative assessment, medicine, Humans, Aspartate Aminotransferases, Alanine aminotransferase, Retrospective Studies, High peak, Transplantation, business.industry, Graft Survival, Alanine Transaminase, Clinical Enzyme Tests, Middle Aged, Tissue Donors, Liver Transplantation, Up-Regulation, Treatment Outcome, Massachusetts, chemistry, Female, 030211 gastroenterology & hepatology, Primary Graft Dysfunction, business, Biomarkers

الوصف: OBJECTIVES: Elevation of transaminases has been used as a marker of hepatic ischemic injury and as a crucial parameter for liver graft assessment. However, analysis of serum transaminases has limitations regarding the quantitative assessment of liver necrosis and is not a reliable predictor of outcomes.MATERIALS AND METHODS: We retrospectively reviewed the medical records of all liver transplants (N = 238) performed at the UMass Memorial Medical Center from 2009 to 2013.RESULTS: Fourteen liver grafts showed high peak aminotransferases alanine aminotransferase (ALT) and aspartate aminotransferase (AST) at > 1000 U/L. This high aminotransferase group was compared with 224 donors with low transaminase levels (ALT/AST < 1000 U/L). The high transaminase donors had a median peak AST level of 3216 U/L (range, 1823-13?030 U/L) and ALT level of 2677 U/L (range, 812-7080 U/L). The high transaminase donors showed higher levels of lactate dehydrogenase, international normalized ratio, total bilirubin, and gamma-glutamyltransferase compared with low transaminase donors; however, only lactate dehydrogenase results reached statistical significance. None of the grafts from the high transaminase donors showed primary nonfunction. Three-year graft and patient survival rates were similar in both groups (75% vs 80% [P = .48] and 72% vs 82% [P = .33], respectively). In an analysis of the discard rate of livers over a 10-year period in the United States using the Scientific Registry of Transplant Recipients database, the discard rate of livers with high aminotransferase levels was 69.14% compared with 22.23% for livers with low transaminase levels.CONCLUSIONS: Liver grafts from donors with high transaminase levels can lead to clinical results that are similar to liver grafts from donors who had lower peak transaminase levels.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce14770b3fc53e9a7693836e56708ccTest
https://doi.org/10.6002/ect.2017.0172Test

المؤلفون: Amer Harky, Alisha Israni, Christopher J. Goulden

المصدر: Reviews in Medical Virology

مصطلحات موضوعية: 2019-20 coronavirus outbreak, Coronavirus disease 2019 (COVID-19), Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coronavirus, medicine.disease_cause, Severity of Illness Index, Fibrin Fibrinogen Degradation Products, Virology, Lymphopenia, Leukocytes, Medicine, Humans, Aspartate Aminotransferases, Creatine Kinase, Coronavirus, Covid‐19, L-Lactate Dehydrogenase, business.industry, Interleukin-6, SARS-CoV-2, biomarkers, COVID-19, Disseminated Intravascular Coagulation, Prognosis, Survival Analysis, Thrombocytopenia, COVID-19 Drug Treatment, Infectious Diseases, Editorial, C-Reactive Protein, Asymptomatic Diseases, pathology, business, Cytokine Release Syndrome

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::09f260b6143d89f98bad20e7934c5f7bTest
http://europepmc.org/articles/PMC8646250Test

المؤلفون: Olga Krysko, Elena Kondakova, Olga Vershinina, Elena Galova, Anna Blagonravova, Ekaterina Gorshkova, Claus Bachert, Mikhail Ivanchenko, Dmitri V. Krysko, Maria Vedunova

المصدر: Frontiers in Immunology, Vol 12 (2021)
FRONTIERS IN IMMUNOLOGY
Frontiers in Immunology

مصطلحات موضوعية: Male, Support Vector Machine, medicine.medical_treatment, Immunology, Disease, Logistic regression, Fibrinogen, Severity of Illness Index, Monocytes, chemistry.chemical_compound, Severity of illness, Medicine and Health Sciences, Humans, Immunology and Allergy, Medicine, Aspartate Aminotransferases, Diagnosis, Computer-Assisted, Prospective Studies, HMGB1 Protein, Interleukin 6, Prospective cohort study, Original Research, Creatinine, IL-6, L-Lactate Dehydrogenase, biology, SARS-CoV-2, business.industry, Macrophages, COVID-19, prediction models, Alanine Transaminase, Middle Aged, RC581-607, Prognosis, artificial intelligence, MODEL, Cytokine, chemistry, CELLS, biology.protein, Cytokines, Female, Artificial intelligence, Immunologic diseases. Allergy, business, Biomarkers, macrophage derived cytokine, medicine.drug

الوصف: BackgroundPrediction of the severity of COVID-19 at its onset is important for providing adequate and timely management to reduce mortality.ObjectiveTo study the prognostic value of damage parameters and cytokines as predictors of severity of COVID-19 using an extensive immunologic profiling and unbiased artificial intelligence methods.MethodsSixty hospitalized COVID-19 patients (30 moderate and 30 severe) and 17 healthy controls were included in the study. The damage indicators high mobility group box 1 (HMGB1), lactate dehydrogenase (LDH), aspartate aminotransferase (AST), alanine aminotransferase (ALT), extensive biochemical analyses, a panel of 47 cytokines and chemokines were analyzed at weeks 1, 2 and 7 along with clinical complaints and CT scans of the lungs. Unbiased artificial intelligence (AI) methods (logistic regression and Support Vector Machine and Random Forest algorithms) were applied to investigate the contribution of each parameter to prediction of the severity of the disease.ResultsOn admission, the severely ill patients had significantly higher levels of LDH, IL-6, monokine induced by gamma interferon (MIG), D-dimer, fibrinogen, glucose than the patients with moderate disease. The levels of macrophage derived cytokine (MDC) were lower in severely ill patients. Based on artificial intelligence analysis, eight parameters (creatinine, glucose, monocyte number, fibrinogen, MDC, MIG, C-reactive protein (CRP) and IL-6 have been identified that could predict with an accuracy of 83−87% whether the patient will develop severe disease.ConclusionThis study identifies the prognostic factors and provides a methodology for making prediction for COVID-19 patients based on widely accepted biomarkers that can be measured in most conventional clinical laboratories worldwide.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::47e36de518e28423473e5225f34c81e1Test
https://www.frontiersin.org/articles/10.3389/fimmu.2021.715072/fullTest

المؤلفون: Hye Kyung Ko, Jun Hyeong Kim, Seungjae Baek, Tae Jin Kim, Min Ji Kang, Jung Mogg Kim, Jeong Rae Yoo, Kyung Mi Lee, Kyung-Ah Hwang, Sang Taek Heo, Keun Hwa Lee, Ju Eun Kim, Mi Soo Yoo, Jiin Lee, TaeHong Ha, Hyunjoo Oh

المصدر: Frontiers in Immunology
Frontiers in Immunology, Vol 12 (2021)

مصطلحات موضوعية: Male, Phlebovirus, Severe Fever with Thrombocytopenia Syndrome, Multiple Organ Failure, Immunology, Antibodies, Viral, South Korea, Republic of Korea, medicine, Immunology and Allergy, Humans, Aspartate Aminotransferases, Viremia, Neutralizing antibody, tick-borne viral diseases, Original Research, Aged, Aged, 80 and over, IL-6, Leukopenia, biology, L-Lactate Dehydrogenase, business.industry, Interleukin-6, SFTS virus, Alanine Transaminase, RC581-607, Middle Aged, Viral Load, biology.organism_classification, medicine.disease, Antibodies, Neutralizing, Interleukin-10, Severe fever with thrombocytopenia syndrome, Dyspnea, Treatment Outcome, IL-10, biology.protein, Cytokines, Female, Viral disease, Immunologic diseases. Allergy, medicine.symptom, Haemaphysalis longicornis, business, Viral load, Severe fever with thrombocytopenia syndrome virus

الوصف: Severe fever with thrombocytopenia syndrome (SFTS) is a new tick-borne viral disease, and most SFTS virus (SFTSV) infections occur via bites from the tick Haemaphysalis longicornis; however, SFTSV transmission can also occur through close contact with an infected patient. SFTS is characterized by acute high fever, thrombocytopenia, leukopenia, elevated serum hepatic enzyme levels, gastrointestinal symptoms, and multiorgan failure and has a 16.2 to 30% mortality rate. In this study, we found that age, dyspnea rates, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase, multiorgan dysfunction score (MODS), viral load, IL-6 levels, and IL-10 levels were higher in patients with fatal disease than in patients with nonfatal disease during the initial clinical course of SFTS. In addition, we found that IL-6 and IL-10 levels, rather than viral load and neutralizing antibody titers, in patients with an SFTSV infection strongly correlated with outcomes (for severe disease with an ultimate outcome of recovery or death).

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b4afba8f91b9ef192db89031c6cf64e7Test
http://europepmc.org/articles/PMC8416084Test

المؤلفون: Carlos Barrios, Álvaro González Fernández, José J. Cerón, Lorena Franco-Martínez, Gonzalo Mariscal, José Enrique de la Rubia Ortí

المصدر: International Journal of Environmental Research and Public Health
Volume 17
Issue 21
International Journal of Environmental Research and Public Health, Vol 17, Iss 8165, p 8165 (2020)

مصطلحات موضوعية: Adult, Male, Saliva, Adolescent, Health, Toxicology and Mutagenesis, Football, lcsh:Medicine, Physiology, Perceived exertion, Muscle damage, Article, 03 medical and health sciences, chemistry.chemical_compound, Young Adult, 0302 clinical medicine, muscle damage, aspartate aminotransferase, Lactate dehydrogenase, gender, Medicine, Humans, rugby sevens, Exertion, Aspartate Aminotransferases, biology, L-Lactate Dehydrogenase, Athletes, business.industry, creatine kinase, lcsh:R, Public Health, Environmental and Occupational Health, lactate dehydrogenase, 030229 sport sciences, biology.organism_classification, chemistry, Spain, biology.protein, Creatine kinase, Female, business, 030217 neurology & neurosurgery

الوصف: Rugby sevens is characterised by continuous exertion and great physical contact per unit of time, leading to muscle damage. It is important to identify markers that can quantify muscle damage in order to improve recovery strategies. The objective of this study was to evaluate the release dynamics of muscle damage markers creatine kinase (CK), lactate dehydrogenase (LDH), and aspartate aminotransferase (AST) in saliva samples when playing rugby sevens, analysing the influence of gender, during the rugby sevens university championship of Spain. The total sample included 27 athletes, divided into two teams of 14 men and 13 women between 18 and 31 years of age. CK, LDH, and AST were quantified from salivary samples collected from each athlete before and after three rugby sevens matches. The modified Borg scale of perceived exertion was also used after each match. When the results were analysed globally, there were no differences in CK and LDH before and after any match, but AST did show differences after two days of completing all matches. In terms of gender, the three enzymes showed different responses in men and women. Regarding the Borg scale, there were only significant differences between men and women after completing all mataches, with a greater perceived exertion in women. Based on our results, it can be stated that that serial matches of rugby sevens can cause changes of different magnitude in AST, CK and LDH activities in saliva, with AST showing the most significant variations and these changes are more pronounced in men than in women.

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::87e70adb7456f399facc08431beaa3c7Test
https://pubmed.ncbi.nlm.nih.gov/33167318Test