دورية أكاديمية
Clinical characteristics of Graves' orbitopathy in patients showing discrepancy between levels from TBII assays and TSI bioassay
| العنوان: | Clinical characteristics of Graves' orbitopathy in patients showing discrepancy between levels from TBII assays and TSI bioassay |
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| المساهمون: | Sun Young Jang, Dong Yeob Shin, Eun Jig Lee, Jin Sook Yoon, Yoon, Jin Sook, Lee, Eun Jig, Shin, Dong Yeob |
| سنة النشر: | 2014 |
| مصطلحات موضوعية: | Adult, Asian Continental Ancestry Group, Autoantibodies/blood, Female, Graves Ophthalmopathy/blood, Graves Ophthalmopathy/pathology, Humans, Immunoglobulins, Thyroid-Stimulating/blood, Male, Middle Aged, Receptors, Thyrotropin/immunology, Retrospective Studies |
| الوصف: | OBJECTIVE: To investigate clinical characteristics of patients with Graves' orbitopathy (GO) who showed discrepancies between levels of thyroid-stimulating immunoglobulin (TSI) and thyrotropin-binding inhibitory immunoglobulin (TBII). DESIGN: Comparative case series. PATIENTS: A total of 317 patients with GO in whom Mc4-TSI and M22-TRAb (third-generation TBII) were measured simultaneously. Patients were divided into four groups according to TRAb levels as followings: Group 1, TBII and TSI < median value; Group 2, TBII �돟 median, TSI < median; Group 3, TBII < median, TSI �돟 median; Group 4, both TBII and TSI �돟 median. MEASUREMENT: Endocrine and ophthalmic clinical manifestations in each group. RESULTS: The median value of M22-TRAb was 6쨌11 IU/l and that of Mc4-TSI was 415쨌1 (SRR%). One hundred seventeen patients were classified as Group 1, 41 patients as Group 2, 41 patients as group 3 and 118 patients as group 4. Mean CAS was significantly higher in Groups 3 (2쨌2) and 4 (2쨌2) than in Groups 1 (1쨌6) and 2 (1쨌4; P = 0쨌001, ANOVA). Mean modified NOSPECS scores were significantly higher (P < 0쨌001, ANOVA) in Groups 3 (4쨌1) and 4 (4쨌1) than in Groups 1 (3쨌1) and 2 (2쨌3). The proportion of patients with hyperthyroidism was larger in Group 2 (85쨌4% [35/41 patients]) than in Group 3 (48쨌8% [20/41 patients]; P = 0쨌002). CONCLUSIONS: GO is more active and severe in patients with predominant Mc4-TSI than in patients with predominant M22-TRAb. Patients with hyperthyroidism were more likely to be included with patients with predominant M22-TRAb than with predominant Mc4-TSI. ; open |
| نوع الوثيقة: | article in journal/newspaper |
| وصف الملف: | 591~597 |
| اللغة: | unknown |
| تدمد: | 2234-2400 2234-2443 24033537 |
| العلاقة: | CLINICAL ENDOSCOPY; J00572; OAK-2014-00741; https://ir.ymlib.yonsei.ac.kr/handle/22282913/98661Test; T201401237; CLINICAL ENDOSCOPY, Vol.80(4) : 591-597, 2014 |
| DOI: | 10.1111/cen.12318 |
| DOI: | 10.1111/cen.12318/abstract |
| الإتاحة: | https://doi.org/10.1111/cen.12318Test https://ir.ymlib.yonsei.ac.kr/handle/22282913/98661Test |
| حقوق: | CC BY-NC-ND 2.0 KR ; https://creativecommons.org/licenses/by-nc-nd/2.0/krTest/ ; free |
| رقم الانضمام: | edsbas.28FDB947 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 22342400 22342443 24033537 |
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| DOI: | 10.1111/cen.12318 |