دورية أكاديمية
Antimicrobial Resistance in Gram-Negative Rods Causing Bacteremia in Hematopoietic Stem Cell Transplant Recipients: Intercontinental Prospective Study of the Infectious Diseases Working Party of the European Bone Marrow Transplantation Group
| العنوان: | Antimicrobial Resistance in Gram-Negative Rods Causing Bacteremia in Hematopoietic Stem Cell Transplant Recipients: Intercontinental Prospective Study of the Infectious Diseases Working Party of the European Bone Marrow Transplantation Group |
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| المؤلفون: | Averbuch, D., Tridello, G., Hoek, J., Mikulska, M., Akan, H., Yaňez San Segundo, L., Pabst, T., Özçelik, T., Klyasova, G., Donnini, I., Wu, D., Gülbas, Z., Zuckerman, T., Botelho De Sousa, A., Beguin, Yves, Xhaard, A., Bachy, E., Ljungman, P., De La Camara, R., Rascon, J., Ruiz Camps, I., Vitek, A., Patriarca, F., Cudillo, L., Vrhovac, R., Shaw, P. J., Wolfs, T., O'Brien, T., Avni, B., Silling, G., Al Sabty, F., Graphakos, S., Sankelo, M., Sengeloev, H., Pillai, S., Matthes, S., Melanthiou, F., Iacobelli, S., Styczynski, J., Engelhard, D., Cesaro, S. |
| المصدر: | Clinical Infectious Diseases, 65 (11), 1819-1828 (2017) |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 2017 |
| المجموعة: | University of Liège: ORBi (Open Repository and Bibliography) |
| مصطلحات موضوعية: | Acinetobacter, Acinetobacter baumannii, Article, Asia, Australia, Enterobacteriaceae, Escherichia coli, Europe, Gram negative bacterium, Gram negative sepsis, Pseudomonas aeruginosa, Stenotrophomonas maltophilia, Human health sciences, Hematology, Sciences de la santé humaine, Hématologie |
| الوصف: | peer reviewed ; Background This intercontinental study aimed to study gram-negative rod (GNR) resistance in hematopoietic stem cell transplantation (HSCT). Methods GNR bacteremias occurring during 6 months post-HSCT (February 2014-May 2015) were prospectively collected, and analyzed for rates and risk factors for resistance to fluoroquinolones, noncarbapenem anti-Pseudomonas β-lactams (noncarbapenems), carbapenems, and multidrug resistance. Results Sixty-five HSCT centers from 25 countries in Europe, Australia, and Asia reported data on 655 GNR episodes and 704 pathogens in 591 patients (Enterobacteriaceae, 73%; nonfermentative rods, 24%; and 3% others). Half of GNRs were fluoroquinolone and noncarbapenem resistant; 18.5% carbapenem resistant; 35.2% multidrug resistant. The total resistance rates were higher in allogeneic HSCT (allo-HSCT) vs autologous HSCT (auto-HSCT) patients (P <.001) but similar in community-acquired infections. Noncarbapenem resistance and multidrug resistance were higher in auto-HSCT patients in centers providing vs not providing fluoroquinolone prophylaxis (P <.01). Resistance rates were higher in southeast vs northwest Europe and similar in children and adults, excluding higher fluoroquinolone- and β-lactam/β-lactamase inhibitor resistance rates in allo-HSCT adults. Non-Klebsiella Enterobacteriaceae were rarely carbapenem resistant. Multivariable analysis revealed resistance risk factors in allo-HSCT patients: fluoroquinolone resistance: adult, prolonged neutropenia, breakthrough on fluoroquinolones; noncarbapenem resistance: hospital-acquired infection, breakthrough on noncarbapenems or other antibiotics (excluding fluoroquinolones, noncarbapenems, carbapenems), donor type; carbapenem resistance: breakthrough on carbapenem, longer hospitalization, intensive care unit, previous other antibiotic therapy; multidrug resistance: longer hospitalization, breakthrough on β-lactam/β-lactamase inhibitors, and carbapenems. Inappropriate empiric therapy and mortality were significantly more ... |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1058-4838 1537-6591 |
| العلاقة: | urn:issn:1058-4838; urn:issn:1537-6591; https://orbi.uliege.be/handle/2268/218795Test; info:hdl:2268/218795; https://orbi.uliege.be/bitstream/2268/218795/1/Bacterial%20resistance-Clin.Infect.dis.pdfTest; scopus-id:2-s2.0-85034820856; info:pmid:29020364 |
| DOI: | 10.1093/cid/cix646 |
| الإتاحة: | https://doi.org/10.1093/cid/cix646Test https://orbi.uliege.be/handle/2268/218795Test https://orbi.uliege.be/bitstream/2268/218795/1/Bacterial%20resistance-Clin.Infect.dis.pdfTest |
| حقوق: | open access ; http://purl.org/coar/access_right/c_abf2Test ; info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.B1762F90 |
| قاعدة البيانات: | BASE |
| تدمد: | 10584838 15376591 |
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| DOI: | 10.1093/cid/cix646 |