Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects
| العنوان: | Glycoprotein YKL-40 Levels in Plasma Are Associated with Fibrotic Changes on HRCT in Asbestos-Exposed Subjects |
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| المؤلفون: | Ritva Järvenpää, Katriina Vuolteenaho, Panu Oksa, Hannu Kankaanranta, Mari Hämäläinen, Tuula Vierikko, Tuija Väänänen, Jukka Uitti, Lauri Lehtimäki, Eeva Moilanen |
| المساهمون: | Lääketieteen ja biotieteiden tiedekunta - Faculty of Medicine and Life Sciences, University of Tampere |
| المصدر: | Mediators of Inflammation, Vol 2017 (2017) Mediators of Inflammation |
| بيانات النشر: | Hindawi Limited, 2017. |
| سنة النشر: | 2017 |
| مصطلحات موضوعية: | Male, 0301 basic medicine, musculoskeletal diseases, Pathology, medicine.medical_specialty, Article Subject, Biolääketieteet - Biomedicine, Pulmonary Fibrosis, Immunology, Asbestosis, Inflammation, medicine.disease_cause, Gastroenterology, Asbestos, 03 medical and health sciences, FEV1/FVC ratio, Fibrosis, Internal medicine, lcsh:Pathology, Humans, Medicine, Chitinase-3-Like Protein 1, Aged, Interleukin-6, business.industry, Cell Biology, Venous blood, Middle Aged, medicine.disease, C-Reactive Protein, 030104 developmental biology, Matrix Metalloproteinase 9, Biomarker (medicine), Complement Factor D, Female, medicine.symptom, business, Wound healing, Research Article, lcsh:RB1-214 |
| الوصف: | YKL-40 is a chitinase-like glycoprotein produced by alternatively activated macrophages that are associated with wound healing and fibrosis. Asbestosis is a chronic asbestos-induced lung disease, in which injury of epithelial cells and activation of alveolar macrophages lead to enhanced collagen production and fibrosis. We studied if YKL-40 is related to inflammation, fibrosis, and/or lung function in subjects exposed to asbestosis. Venous blood samples were collected from 85 men with moderate or heavy occupational asbestos exposure and from 28 healthy, age-matched controls. Levels of plasma YKL-40, CRP, IL-6, adipsin, and MMP-9 were measured with enzyme-linked immunosorbent assay (ELISA). Plasma YKL-40 levels were significantly higher in subjects with asbestosis (n=19) than in those with no fibrotic findings in HRCT following asbestos exposure (n=66) or in unexposed healthy controls. In asbestos-exposed subjects, plasma YKL-40 correlated negatively with lung function capacity parameters FVC (Pearson’s r −0.259, p=0.018) and FEV1 (Pearson’s r −0.240, p=0.028) and positively with CRP (Spearman’s rho 0.371, p<0.001), IL-6 (Spearman’s rho 0.314, p=0.003), adipsin (Spearman’s rho 0.459, p<0.001), and MMP-9 (Spearman’s rho 0.243, p=0.025). The present finding suggests YKL-40 as a biomarker associated with fibrosis and inflammation in asbestos-exposed subjects. |
| وصف الملف: | text/xhtml; fulltext |
| اللغة: | English |
| تدمد: | 1466-1861 0962-9351 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::73dcbb60cc68c540828bc74e38c04bbeTest https://doaj.org/article/59030f4c6ba44e47a34b5793ed151114Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....73dcbb60cc68c540828bc74e38c04bbe |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14661861 09629351 |
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