دورية أكاديمية
MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons.
| العنوان: | MSUT2 regulates tau spreading via adenosinergic signaling mediated ASAP1 pathway in neurons. |
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| المؤلفون: | Xu, Hong, Qiu, Qi, Hu, Peng, Hoxha, Kevt'her, Jang, Elliot, O'Reilly, Mia, Kim, Christopher, He, Zhuohao, Marotta, Nicholas, Changolkar, Lakshmi, Zhang, Bin, Wu, Hao, Schellenberg, Gerard D, Kraemer, Brian, Luk, Kelvin C, Lee, Edward B, Trojanowski, John Q, Brunden, Kurt R, Lee, Virginia M-Y |
| المصدر: | Acta Neuropathol ; ISSN:1432-0533 ; Volume:147 ; Issue:1 |
| بيانات النشر: | Springer |
| سنة النشر: | 2024 |
| المجموعة: | PubMed Central (PMC) |
| مصطلحات موضوعية: | A1AR, ASAP1, MSUT2, Tau, Tau spreading |
| الوصف: | Inclusions comprised of microtubule-associated protein tau (tau) are implicated in a group of neurodegenerative diseases, collectively known as tauopathies, that include Alzheimer's disease (AD). The spreading of misfolded tau "seeds" along neuronal networks is thought to play a crucial role in the progression of tau pathology. Consequently, restricting the release or uptake of tau seeds may inhibit the spread of tau pathology and potentially halt the advancement of the disease. Previous studies have demonstrated that the Mammalian Suppressor of Tauopathy 2 (MSUT2), an RNA binding protein, modulates tau pathogenesis in a transgenic mouse model. In this study, we investigated the impact of MSUT2 on tau pathogenesis using tau seeding models. Our findings indicate that the loss of MSUT2 mitigates human tau seed-induced pathology in neuron cultures and mouse models. In addition, MSUT2 regulates many gene transcripts, including the Adenosine Receptor 1 (A1AR), and we show that down regulation or inhibition of A1AR modulates the activity of the "ArfGAP with SH3 Domain, Ankyrin Repeat, and PH Domain 1 protein" (ASAP1), thereby influencing the internalization of pathogenic tau seeds into neurons resulting in reduction of tau pathology. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| العلاقة: | https://doi.org/10.1007/s00401-024-02703-3Test; https://pubmed.ncbi.nlm.nih.gov/38472475Test; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933148Test/ |
| DOI: | 10.1007/s00401-024-02703-3 |
| الإتاحة: | https://doi.org/10.1007/s00401-024-02703-3Test https://pubmed.ncbi.nlm.nih.gov/38472475Test https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10933148Test/ |
| حقوق: | © 2024. The Author(s). |
| رقم الانضمام: | edsbas.47EBB899 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1007/s00401-024-02703-3 |
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