التفاصيل البيبلوغرافية
| العنوان: |
Outcomes of Immunocompromised Adults Hospitalized With Laboratory-confirmed Influenza in the United States, 2011–2015. |
| المؤلفون: |
Collins, Jennifer P, Campbell, Angela P, Openo, Kyle, Farley, Monica M, Cummings, Charisse Nitura, Hill, Mary, Schaffner, William, Lindegren, Mary Lou, Thomas, Ann, Billing, Laurie, Bennett, Nancy, Spina, Nancy, Bargsten, Marisa, Lynfield, Ruth, Eckel, Seth, Ryan, Patricia, Yousey-Hindes, Kimberly, Herlihy, Rachel, Kirley, Pam Daily, Garg, Shikha |
| المصدر: |
Clinical Infectious Diseases; 5/15/2020, Vol. 79 Issue 10, p2121-2130, 10p |
| مصطلحات موضوعية: |
INFLUENZA diagnosis, INFLUENZA treatment, AGE distribution, ANTIVIRAL agents, ARTIFICIAL respiration, CANCER patients, COMPARATIVE studies, CONFIDENCE intervals, CRITICAL care medicine, CLINICAL pathology, DISEASES, HIV-positive persons, HOSPITAL care, LENGTH of stay in hospitals, IMMUNIZATION, IMMUNOTHERAPY, INFLUENZA, INFLUENZA vaccines, EVALUATION of medical care, MORTALITY, MULTIVARIATE analysis, NONSTEROIDAL anti-inflammatory agents, PUBLIC health surveillance, RARE diseases, TIME, MULTIPLE regression analysis, PROPORTIONAL hazards models, DESCRIPTIVE statistics, IMMUNOCOMPROMISED patients, ODDS ratio, EVALUATION, SYMPTOMS |
| مصطلحات جغرافية: |
UNITED States |
| الشركة/الكيان: |
CENTERS for Disease Control & Prevention (U.S.) |
| مستخلص: |
Background Hospitalized immunocompromised (IC) adults with influenza may have worse outcomes than hospitalized non-IC adults. Methods We identified adults hospitalized with laboratory-confirmed influenza during 2011–2015 seasons through CDC's Influenza Hospitalization Surveillance Network. IC patients had human immunodefiency virus (HIV)/AIDS, cancer, stem cell or organ transplantation, nonsteroid immunosuppressive therapy, immunoglobulin deficiency, asplenia, and/or other rare conditions. We compared demographic and clinical characteristics of IC and non-IC adults using descriptive statistics. Multivariable logistic regression and Cox proportional hazards models controlled for confounding by patient demographic characteristics, pre-existing medical conditions, influenza vaccination, and other factors. Results Among 35 348 adults, 3633 (10%) were IC; cancer (44%), nonsteroid immunosuppressive therapy (44%), and HIV (18%) were most common. IC patients were more likely than non-IC patients to have received influenza vaccination (53% vs 46%; P <.001), and ~85% of both groups received antivirals. In multivariable analysis, IC adults had higher mortality (adjusted odds ratio [aOR], 1.46; 95% confidence interval [CI], 1.20–1.76). Intensive care was more likely among IC patients 65–79 years (aOR, 1.25; 95% CI, 1.06–1.48) and those >80 years (aOR, 1.35; 95% CI, 1.06–1.73) compared with non-IC patients in those age groups. IC patients were hospitalized longer (adjusted hazard ratio of discharge, 0.86; 95% CI,.83–.88) and more likely to require mechanical ventilation (aOR, 1.19; 95% CI, 1.05–1.36). Conclusions Substantial morbidity and mortality occurred among IC adults hospitalized with influenza. Influenza vaccination and antiviral administration could be increased in both IC and non-IC adults. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
