دورية أكاديمية
DNA and chromatin structure: Analysis of the sex chromosomal equipment in spermatozoa of a 47, XYY male using two-colour fluorescence in-situ hybridization
| العنوان: | DNA and chromatin structure: Analysis of the sex chromosomal equipment in spermatozoa of a 47, XYY male using two-colour fluorescence in-situ hybridization |
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| المؤلفون: | Mercier, S., Morel, F., Roux, C., Clavequin, M.C., Bresson, J.L. |
| بيانات النشر: | Oxford University Press |
| سنة النشر: | 1996 |
| المجموعة: | HighWire Press (Stanford University) |
| مصطلحات موضوعية: | ARTICLES |
| الوصف: | The sex chromosomes in spermatozoa of a 47, XYY fertile male were analysed simultaneously by dual fluorescence in-situ hybridization (FISH), with two probes (pHY2.1 and pXBR). Of the 100 000 cells analysed, 95 179 spermatozoa (95.18%) exhibited one or more hybridization signals. Of the hybridized nuclei, 85.37% showed a normal sex chromosome constitution (37.37% X-bearing cells and 48.00% Y-bearing cells), with an X:Y ratio of 0.78:1. A total of 14.63% of the hybridized nuclei exhibited sex chromosome aneuploidy with a majority of XY-and YY-bearing spermatozoa (9.37 and 4.65% respectively). Even if the majority of spermatozoa have chromosomal haploidy, a large proportion of them exhibits numerical errors for the sex chromosomes. These observations raise questions about the commonly-admitted notions concerning the absence of chromosomal risk for XYY male offspring. |
| نوع الوثيقة: | text |
| وصف الملف: | text/html |
| اللغة: | English |
| العلاقة: | http://molehr.oxfordjournals.org/cgi/content/short/2/7/485Test; http://dx.doi.org/10.1093/molehr/2.7.485Test |
| DOI: | 10.1093/molehr/2.7.485 |
| الإتاحة: | https://doi.org/10.1093/molehr/2.7.485Test http://molehr.oxfordjournals.org/cgi/content/short/2/7/485Test |
| حقوق: | Copyright (C) 1996, Oxford University Press |
| رقم الانضمام: | edsbas.9C5BFA44 |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/molehr/2.7.485 |
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