Curdlan-Based Hydrogels for Potential Application as Dressings for Promotion of Skin Wound Healing—Preliminary In Vitro Studies
| العنوان: | Curdlan-Based Hydrogels for Potential Application as Dressings for Promotion of Skin Wound Healing—Preliminary In Vitro Studies |
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| المؤلفون: | Grazyna Ginalska, Aleksandra Nurzynska, Katarzyna Klimek, Łukasz Szajnecki, Krzysztof Pałka |
| المصدر: | Materials, Vol 14, Iss 2344, p 2344 (2021) Materials Volume 14 Issue 9 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Technology, Biocompatibility, wound exudate, chemistry.chemical_element, Human skin, 02 engineering and technology, Curdlan, Calcium, 01 natural sciences, Article, chemistry.chemical_compound, biocompatibility, bioactive wound dressing, In vivo, 0103 physical sciences, medicine, General Materials Science, Fibroblast, hydrogels, calcium ions, 010302 applied physics, Microscopy, QC120-168.85, integumentary system, QH201-278.5, Biomaterial, Engineering (General). Civil engineering (General), 021001 nanoscience & nanotechnology, skin fibroblasts, TK1-9971, medicine.anatomical_structure, Descriptive and experimental mechanics, chemistry, chronic wounds, Self-healing hydrogels, Electrical engineering. Electronics. Nuclear engineering, TA1-2040, 0210 nano-technology, Biomedical engineering |
| الوصف: | The aim of this work was to establish whether novel curdlan-based hydrogels enriched with Ca2+ ions may be considered as potential candidates for dressings, for the acceleration of skin wound healing. Firstly, biomaterials were allocated for evaluation of structural and mechanical properties. Subsequently, the ability of hydrogels to absorb simulated wound fluid and water vapor permeability, as well their capacity to release calcium ions, was evaluated. The biocompatibility of biomaterials was assessed using normal human skin fibroblasts. Importantly, the main features of the obtained curdlan-based hydrogels were compared with those of KALTOSTAT® (a commercial calcium sodium alginate wound dressing). The obtained results showed that curdlan-based biomaterials possessed a mesoporous structure (pore diameter ranged from 14–48 nm) and exhibited a good ability to absorb simulated wound fluid (swelling ratio close to 974–1229%). Moreover, in a wet state, they enabled proper water vapor transmission rate (> 2000 g/m2/day), thanks to their hydrogel structure. Finally, it was found that biomaterial composed of 11 wt.% of curdlan (Cur_11%) possessed the most desirable biological properties in vitro. It released a beneficial amount of calcium ions to the aqueous environment (approximately 6.12 mM), which significantly enhanced fibroblast viability and proliferation. Taking into account the beneficial properties of Cur_11% biomaterial, it seems justified to subject it to more advanced cell culture experiments in vitro and to in vivo studies in order to determine its precise influence on skin wound healing. |
| وصف الملف: | application/pdf |
| تدمد: | 1996-1944 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::79e959843101d8ac9c53771b66a15969Test https://doi.org/10.3390/ma14092344Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....79e959843101d8ac9c53771b66a15969 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 19961944 |
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