المؤلفون: Bradley T. Hyman, Nathan T. Johnson, Sarah A. Boswell, Mark W. Albers, Kyle Evans, George Zhou, Artem Sokolov, Clemens B. Hug, Steven Rodriguez, Peter K. Sorger, Nienke Moret, Petar Todorov

المصدر: Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Nature Communications

مصطلحات موضوعية: 0301 basic medicine, Prescription Drugs, Polypharmacology, Science, Primary Cell Culture, MEDLINE, General Physics and Astronomy, Nerve Tissue Proteins, Disease, Machine learning, computer.software_genre, Severity of Illness Index, Article, General Biochemistry, Genetics and Molecular Biology, Machine Learning, Food and drug administration, 03 medical and health sciences, 0302 clinical medicine, Alzheimer Disease, Humans, Medicine, Nootropic Agents, Repurposing, Cerebral Cortex, Neurons, Pharmacology, Multidisciplinary, business.industry, Gene Expression Profiling, Drug Repositioning, Drugs, Investigational, General Chemistry, Alzheimer's disease, High-Throughput Screening Assays, Clinical trial, Drug repositioning, Neuroprotective Agents, 030104 developmental biology, Gene Expression Regulation, Pharmacogenetics, Biomarker (medicine), Identification (biology), Artificial intelligence, business, computer, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad68ff5f7983e8e48180f85eeb89cb1aTest
https://doaj.orgTest/article/93e763bd3055417ea9c559a7b6fa24d5

المؤلفون: Jason Qian, Benjamin L. Gaudio, Zhi-xiang Lu, Ryan T. Ingram, Michael Springer, Sarah A. Boswell, Christopher Chidley, Mary E. Pettit, Rebecca H. Ward, Jesse Fajnzylber, Jonathan Z. Li

المصدر: Nature Communications, Vol 11, Iss 1, Pp 1-10 (2020)
Nature Communications
bioRxiv

مصطلحات موضوعية: 0301 basic medicine, Computer science, Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), Science, Loop-mediated isothermal amplification, Recombinase Polymerase Amplification, General Physics and Astronomy, Economic shortage, 02 engineering and technology, Computational biology, Real-Time Polymerase Chain Reaction, Article, General Biochemistry, Genetics and Molecular Biology, Recombinases, 03 medical and health sciences, Betacoronavirus, COVID-19 Testing, Humans, Instrumentation (computer programming), Saliva, lcsh:Science, Detection limit, Multidisciplinary, Assay systems, Clinical Laboratory Techniques, SARS-CoV-2, Virion, Diagnostic test, RNA-Directed DNA Polymerase, General Chemistry, 021001 nanoscience & nanotechnology, Highly sensitive, 030104 developmental biology, Real-time polymerase chain reaction, RNA, RNA, Viral, lcsh:Q, Sample collection, RNA extraction, 0210 nano-technology, Coronavirus Infections, PCR-based techniques, Nucleic Acid Amplification Techniques, Nucleic acid detection

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4b84263a43a8e101e8a3f0ba897d3daTest
https://doaj.orgTest/article/1fea287ae7e64a1da7dfd8eee7f11721

المؤلفون: Sara J. Buhrlage, William C. Hahn, Sumner Perera, Ellen Weisberg, Robert S. Magin, Kenneth C. Anderson, Dharminder Chauhan, Arghya Ray, Wai Cheung Chan, Nathan J. Schauer, Laura M. Doherty, Björn Stolte, Sirano Dhe-Paganon, Rebekka M. Roberts, Jarrod A. Marto, Wanyi Hu, Sarah A. Boswell, James D. Griffin, Scott B. Ficarro, Peter K. Sorger, Andrew O. Giacomelli, Jianing Li, Kimberly Stegmaier, Roxana E. Iacob, Kyle T. McKay, John R. Engen, Xiaoxi Liu

المصدر: Scientific Reports, Vol 10, Iss 1, Pp 1-15 (2020)
Scientific Reports

مصطلحات موضوعية: lcsh:Medicine, Antineoplastic Agents, Apoptosis, Article, Target validation, Deubiquitinating enzyme, Ubiquitin-Specific Peptidase 7, 03 medical and health sciences, 0302 clinical medicine, Ubiquitin, Cell Line, Tumor, Humans, Cytotoxic T cell, PTEN, Protease Inhibitors, lcsh:Science, Cell Proliferation, 030304 developmental biology, 0303 health sciences, Multidisciplinary, biology, Chemistry, Small molecules, lcsh:R, Ubiquitination, 3. Good health, Cell culture, 030220 oncology & carcinogenesis, Cancer cell, FOXO4, MCF-7 Cells, biology.protein, Cancer research, Mdm2, lcsh:Q, Tumor Suppressor Protein p53

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89403c0f98aeff7c94fa67b62b62d125Test
http://link.springer.comTest/article/10.1038/s41598-020-62076-x

المؤلفون: Michael Springer, Zhi-xiang Lu, Jason Qian, Christopher P. Mancuso, Sarah A. Boswell

المصدر: Anal Chem

مصطلحات موضوعية: Analyte, Coronavirus disease 2019 (COVID-19), Chemistry, SARS-CoV-2, 010401 analytical chemistry, Recombinase Polymerase Amplification, COVID-19, Nucleic acid amplification technique, Computational biology, 010402 general chemistry, 01 natural sciences, Sensitivity and Specificity, Article, 0104 chemical sciences, Analytical Chemistry, Recombinases, chemistry.chemical_compound, Molecular Diagnostic Techniques, Nucleic acid, Recombinase, Humans, Semi quantitative, Nucleic Acid Amplification Techniques, DNA

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b0595d6e34bf454cf9fde3e1758f5734Test
https://pubmed.ncbi.nlm.nih.gov/34180655Test

المؤلفون: G. Paolo Dotto, Anne J. Ridley, Sarah A. Boswell, Pat P. Ongusaha, Hyung Gu Kim, Stuart A. Aaronson, Channing J. Der, Sam W. Lee, Young-Bum Kim

مصطلحات موضوعية: rho GTP-Binding Proteins, Programmed cell death, Stress fiber, DNA damage, Cell Survival, Rho family of GTPases, Apoptosis, Genotoxic Stress, GTPase, Protein Serine-Threonine Kinases, General Biochemistry, Genetics and Molecular Biology, Article, Cell Line, Mice, Cell Line, Tumor, Animals, Humans, rho-Associated Kinases, biology, Rnd3, Gene Expression Profiling, Intracellular Signaling Peptides and Proteins, Fibroblasts, Actin cytoskeleton, Genes, p53, Cell biology, Up-Regulation, biology.protein, Tumor Suppressor Protein p53, General Agricultural and Biological Sciences, DNA Damage, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f78c9f158539ae7748edc02fe23f3223Test
https://europepmc.org/articles/PMC6644033Test/

المؤلفون: Robert A. Everley, Sarah A. Boswell, Alison E. Ringel, Huan Wang, Kristina Holton, Marcia C. Haigis, Adam C. Palmer, Connor A. Jacobson, Noga Ron-Harel, Laura E. Maliszewski, Alison R. Erickson, Peter K. Sorger, Robert P. Sheehan

المصدر: Cell Syst

مصطلحات موضوعية: Sorafenib, Histology, medicine.drug_class, Acclimatization, Induced Pluripotent Stem Cells, Antineoplastic Agents, Lapatinib, Tyrosine-kinase inhibitor, Article, Pathology and Forensic Medicine, 03 medical and health sciences, Erlotinib Hydrochloride, 0302 clinical medicine, medicine, Sunitinib, Humans, Myocytes, Cardiac, Protein Kinase Inhibitors, Cells, Cultured, 030304 developmental biology, Cardiotoxicity, 0303 health sciences, Chemistry, Gene Expression Profiling, Cell Differentiation, Cell Biology, Protein-Tyrosine Kinases, 3. Good health, Anaerobic glycolysis, Cancer research, Erlotinib, Signal transduction, Tyrosine kinase, 030217 neurology & neurosurgery, medicine.drug, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c741c32f5482e4c26da8536963c8d7aTest
https://pubmed.ncbi.nlm.nih.gov/31078528Test

المؤلفون: Caitlin E. Mills, Mirra Chung, Marc Hafner, Sarah A. Boswell, Dejan Juric, Peter K. Sorger, Charlotte S. Walmsley, Kartik Subramanian, Changchang Liu, Chen Chen, Robert A. Everley

مصطلحات موضوعية: Polypharmacology, Clinical Biochemistry, Cyclin A, Mice, Nude, Computational biology, Palbociclib, 01 natural sciences, Biochemistry, Article, 03 medical and health sciences, chemistry.chemical_compound, Mice, 0302 clinical medicine, Drug Discovery, Animals, Humans, Molecular Biology, Abemaciclib, Protein Kinase Inhibitors, 030304 developmental biology, Pharmacology, 0303 health sciences, Cyclin-dependent kinase 1, biology, 010405 organic chemistry, Kinase, United States Food and Drug Administration, Cyclin-dependent kinase 2, Cyclin-Dependent Kinase 4, Cyclin-Dependent Kinase 6, Alvocidib, United States, 0104 chemical sciences, 3. Good health, chemistry, 030220 oncology & carcinogenesis, biology.protein, Cancer research, Molecular Medicine, Female, CDK inhibitor

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58df924a512f6bd0acbb1e8b8ea91cfaTest

المؤلفون: Heather M Landry, L. Stirling Churchman, Andrew Snavely, Michael Springer, Jesse M. Gray, Sarah A. Boswell

مصطلحات موضوعية: 0301 basic medicine, Transcription Elongation, Genetic, RNA polymerase II, Deep sequencing, Article, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Transcription (biology), RNA polymerase, Biflavonoids, Humans, RNA, Messenger, Molecular Biology, Gene, biology, Chemistry, Sequence Analysis, RNA, RNA, Cell Biology, Molecular biology, Cell biology, High-Throughput Screening Assays, 030104 developmental biology, RNA splicing, biology.protein, Cyclin-dependent kinase 9, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92c9adcd579f920308e23566c50d0bc5Test
https://europepmc.org/articles/PMC5688950Test/

المؤلفون: Sarah A. Boswell, Asaf Rotem, Benjamin Izar, Jia-Ren Lin, Gregory J. Baker, Mohammad Fallahi-Sichani, Verena Becker, Peter K. Sorger, Parin Shah, Levi A. Garraway

المساهمون: Broad Institute of MIT and Harvard, Garraway, Levi

المصدر: European Molecular Biology Organization (EMBO)
Molecular Systems Biology

مصطلحات موضوعية: 0301 basic medicine, MAPK/ERK pathway, Indoles, Cellular differentiation, BRAFV600E melanomas, Proto-Oncogene Proteins B-raf, Mice, Molecular Biology of Disease, Melanoma, Quantitative Biology & Dynamical Systems, Sulfonamides, Kinase, Applied Mathematics, Cell Differentiation, Articles, 3. Good health, Cell biology, Gene Expression Regulation, Neoplastic, Cell killing, Computational Theory and Mathematics, Signal transduction, Single-Cell Analysis, General Agricultural and Biological Sciences, Information Systems, Proto-oncogene tyrosine-protein kinase Src, Signal Transduction, Cell Survival, MAP Kinase Signaling System, Nerve Tissue Proteins, Receptors, Nerve Growth Factor, Biology, General Biochemistry, Genetics and Molecular Biology, Article, 03 medical and health sciences, Cell Line, Tumor, Animals, Humans, Cell Proliferation, General Immunology and Microbiology, Cell growth, Gene Expression Profiling, adaptive and reversible drug resistance, Xenograft Model Antitumor Assays, 030104 developmental biology, Vemurafenib, Drug Resistance, Neoplasm, Mutation, RAF and MEK inhibitors, de‐differentiated NGFRHigh state

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7994e8b553e89cba3ee4a5cb14a72f84Test
http://hdl.handle.net/1721.1/109938Test

المؤلفون: Pat P. Ongusaha, Hyung Gu Kim, Young-Bum Kim, G. Paolo Dotto, Stuart A. Aaronson, Sarah A. Boswell, Anne J. Ridley, Channing J. Der, Sam W. Lee

المصدر: Current Biology. 26:2221-2222

مصطلحات موضوعية: 0301 basic medicine, Programmed cell death, Stress fiber, Agricultural and Biological Sciences(all), Rnd3, Biochemistry, Genetics and Molecular Biology(all), Rho family of GTPases, CELLCYCLE, GTPase, Genotoxic Stress, Biology, Actin cytoskeleton, Molecular biology, Article, General Biochemistry, Genetics and Molecular Biology, Cell biology, 03 medical and health sciences, 030104 developmental biology, Apoptosis, biology.protein, CELLBIO, Signal transduction, Target gene, General Agricultural and Biological Sciences

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::faa563887882526c87ffc43332d400a1Test
https://doi.org/10.1016/j.cub.2016.07.072Test