نتائج البحث - "Richard R. Neubig"

1

Inhibition of the Myocardin-Related Transcription Factor Pathway Increases Efficacy of Trametinib in NRAS-Mutant Melanoma Cell Lines

المؤلفون: Kathleen A. Gallo, Charuta C. Palsuledesai, Thomas S. Dexheimer, Richard R. Neubig, Sean A. Misek, Kathryn M. Appleton, Maja K. Blake, Joseph W. Zagorski

المصدر: Cancers
Cancers, Vol 13, Iss 2012, p 2012 (2021)
Volume 13
Issue 9

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12985d711b8c5210b9b3b6ec54be20d1Test
http://europepmc.org/articles/PMC8122681Test

2

Identifying chemopreventive agents for obesity-associated cancers using an efficient, 3D high-throughput transformation assay

المؤلفون: Vanessa Benham, Karen T. Liby, Blair Bullard, Thomas S. Dexheimer, Richard R. Neubig, Jamie J. Bernard, Matthew P. Bernard

المصدر: Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)
Scientific Reports

مصطلحات موضوعية: 0301 basic medicine, food.ingredient, medicine.medical_treatment, Science, Cell Culture Techniques, Antineoplastic Agents, Soft Agar Assay, Fibroblast growth factor, Models, Biological, Article, Cancer prevention, Malignant transformation, Mice, 03 medical and health sciences, 0302 clinical medicine, food, Neoplasms, medicine, Animals, Humans, Agar, Obesity, Fluvastatin, Cell Proliferation, Podophyllotoxin, Skin, Insulin-like growth factor 1 receptor, Multidisciplinary, Chemistry, Growth factor, Fibroblasts, High-Throughput Screening Assays, 3. Good health, Cell Transformation, Neoplastic, 030104 developmental biology, Risk factors, Cell culture, Cancer research, Picropodophyllin, Medicine, Fibroblast Growth Factor 2, Drug Screening Assays, Antitumor, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44aa9e996ad12159fc21b3ac42a8cb69Test
https://doaj.orgTest/article/ed4f3360f28b4854a3d1704bfd5877cc

3

5-Aryl-1,3,4-oxadiazol-2-ylthioalkanoic Acids: A Highly Potent New Class of Inhibitors of Rho/Myocardin-Related Transcription Factor (MRTF)/Serum Response Factor (SRF)-Mediated Gene Transcription as Potential Antifibrotic Agents for Scleroderma

المؤلفون: Dinesh Khanna, Duxin Sun, Marc Bailie, Thomas S. Dexheimer, Richard R. Neubig, Bo Wen, Jeffrey R. Leipprandt, Scott D. Larsen, Pei-Suen Tsou, Andrew J. Haak, Kim Hutchings, Erika M. Lisabeth, Phillip L. Campbell, Dylan Kahl, David A. Fox

المصدر: Journal of Medicinal Chemistry. 62:4350-4369

مصطلحات موضوعية: rho GTP-Binding Proteins, Serum Response Factor, Transcription, Genetic, Carboxylic Acids, 01 natural sciences, Article, Scleroderma, Structure-Activity Relationship, 03 medical and health sciences, chemistry.chemical_compound, Drug Discovery, Serum response factor, medicine, Animals, Luciferase, Enzyme Inhibitors, Transcription factor, Skin, 030304 developmental biology, Oxadiazoles, 0303 health sciences, Scleroderma, Systemic, Molecular Structure, Aryl, Connective Tissue Growth Factor, medicine.disease, Serum Response Element, Fibrosis, Phenotype, 0104 chemical sciences, Mice, Inbred C57BL, 010404 medicinal & biomolecular chemistry, chemistry, Myocardin, Microsomes, Liver, Trans-Activators, Cancer research, Molecular Medicine, Female, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dde3f247ab6ce076613b75c660a77076Test
https://doi.org/10.1021/acs.jmedchem.8b01772Test

4

Identification of Pirin as a Molecular Target of the CCG-1423/CCG-203971 Series of Antifibrotic and Antimetastatic Compounds

المؤلفون: Erika M. Lisabeth, Dylan Kahl, Indiwari Gopallawa, Sarah E. Haynes, Sean A. Misek, Phillip L. Campbell, Thomas S. Dexheimer, Dinesh Khanna, David A. Fox, Xiangshu Jin, Brent R. Martin, Scott D. Larsen, Richard R. Neubig

المصدر: ACS Pharmacology & Translational Science. 2:92-100

مصطلحات موضوعية: Pharmacology, Pharmacology (medical), Article

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e04156d0c2d45fc9015adba97c002ebTest
https://doi.org/10.1021/acsptsci.8b00048Test

5

Role of hippocampal 5-HT1A receptors in the antidepressant-like phenotype of mice expressing RGS-insensitive Gαi2 protein

المؤلفون: Richard R. Neubig, John R. Traynor, Emily M. Jutkiewicz, Carrie R. Ferrario, Nicolas B. Senese, Max F. Oginsky

المصدر: Neuropharmacology. 141:296-304

مصطلحات موضوعية: Male, 0301 basic medicine, Agonist, Microinjections, Pyridines, medicine.drug_class, G protein, Gi alpha subunit, Serotonin 5-HT1 Receptor Antagonists, Hippocampal formation, Hippocampus, Piperazines, Article, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, medicine, Animals, Gene Knock-In Techniques, Receptor, CA1 Region, Hippocampal, 5-HT receptor, Pharmacology, 8-Hydroxy-2-(di-n-propylamino)tetralin, Chemistry, Pyramidal Cells, Immobility Response, Tonic, Serotonin 5-HT1 Receptor Agonists, Tail suspension test, Cell biology, Phenotype, 030104 developmental biology, Receptor, Serotonin, 5-HT1A, Female, GTP-Binding Protein alpha Subunit, Gi2, RGS Proteins

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80a3202a71c6937674dd68e47914db81Test
https://doi.org/10.1016/j.neuropharm.2018.09.002Test

6

Differential Protein Dynamics of Regulators of G-Protein Signaling: Role in Specificity of Small-Molecule Inhibitors

المؤلفون: Vincent Shaw, Hossein Mohammadiarani, Richard R. Neubig, Harish Vashisth

المصدر: Journal of the American Chemical Society. 140:3454-3460

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bfe712f1bc56a3d9e320d892f38c8520Test
https://doi.org/10.1021/jacs.7b13778Test

7

Movement disorder in GNAO1 encephalopathy associated with gain-of-function mutations

المؤلفون: Aysegul O. Gezer, Behirda Karaj, Vincent Shaw, Huijie Feng, Richard R. Neubig, Benita Sjögren

المصدر: Neurology. 89:762-770

مصطلحات موضوعية: Male, 0301 basic medicine, medicine.medical_specialty, Movement disorders, Adolescent, Encephalopathy, Mutagenesis (molecular biology technique), GTP-Binding Protein alpha Subunits, Gi-Go, Biology, Blotting, Far-Western, Transfection, medicine.disease_cause, GNAO1, Article, 03 medical and health sciences, Epilepsy, chemistry.chemical_compound, 0302 clinical medicine, Receptors, Adrenergic, alpha-2, Internal medicine, Cyclic AMP, medicine, Humans, Cyclic adenosine monophosphate, Child, Genetic Association Studies, Loss function, Brain Diseases, Mutation, Dyskinesias, Movement Disorders, Infant, medicine.disease, HEK293 Cells, 030104 developmental biology, Endocrinology, chemistry, Child, Preschool, Gain of Function Mutation, Female, Neurology (clinical), medicine.symptom, 030217 neurology & neurosurgery

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c6b3d924f5ad31c70f35ccb3afa19e5Test
https://doi.org/10.1212/wnl.0000000000004262Test

8

Pharmacological Inhibition of Myocardin-related Transcription Factor Pathway Blocks Lung Metastases of RhoC-Overexpressing Melanoma

المؤلفون: Jessica L. Bell, Andrew J. Haak, Cheryl E. Rockwell, Yajing Ji, Scott D. Larsen, Monique Verhaegen, Melanie A. Krook, Kathryn M. Appleton, Susan M. Wade, Sean A. Misek, Erika M. Lisabeth, Merlin Airik, Elizabeth R. Lawlor, Richard R. Neubig

المصدر: Molecular Cancer Therapeutics. 16:193-204

مصطلحات موضوعية: rho GTP-Binding Proteins, 0301 basic medicine, Cancer Research, Lung Neoplasms, Transcription, Genetic, Nipecotic Acids, RhoC, Gene Expression, Antineoplastic Agents, Biology, Article, Metastasis, Mice, 03 medical and health sciences, Cell Movement, Cell Line, Tumor, medicine, Animals, Humans, Neoplasm Metastasis, Melanoma, neoplasms, Transcription factor, Cell Proliferation, Cell Cycle, Cell migration, Cell cycle, medicine.disease, Xenograft Model Antitumor Assays, Actins, Disease Models, Animal, 030104 developmental biology, Oncology, rhoC GTP-Binding Protein, Myocardin, Immunology, Disease Progression, Trans-Activators, Cancer research, biology.protein, Female, RhoC GTP-Binding Protein, Signal Transduction

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffaf3d0bc3c68f639105c174d822a2f4Test
https://doi.org/10.1158/1535-7163.mct-16-0482Test

9

The role of regulator of G protein signaling 4 in delta-opioid receptor-mediated behaviors

المؤلفون: Isaac J. Dripps, Qin Wang, Emily M. Jutkiewicz, Kenner C. Rice, John R. Traynor, Richard R. Neubig

المصدر: Psychopharmacology. 234:29-39

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3a4d9b367381f3b28ee0c7aaf27304Test
https://doi.org/10.1007/s00213-016-4432-5Test

10

The Rho/MRTF pathway inhibitor CCG-222740 reduces stellate cell activation and modulates immune cell populations in KrasG12D; Pdx1-Cre (KC) mice

المؤلفون: Erika M. Lisabeth, Ana S. Leal, Karen T. Liby, Richard R. Neubig, Sean A. Misek

المصدر: Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-12 (2019)

مصطلحات موضوعية: Cancer microenvironment, Male, 0301 basic medicine, RHOA, Stromal cell, Cell, RhoC, lcsh:Medicine, Drug development, Mice, Transgenic, Adenocarcinoma, Article, Proto-Oncogene Proteins p21(ras), Mice, 03 medical and health sciences, 0302 clinical medicine, Pancreatic cancer, medicine, Animals, Gene Knock-In Techniques, lcsh:Science, Homeodomain Proteins, Tumor microenvironment, Multidisciplinary, Integrases, biology, Chemistry, lcsh:R, Pancreatic Stellate Cells, medicine.disease, Mice, Inbred C57BL, Pancreatic Neoplasms, Disease Models, Animal, RAW 264.7 Cells, 030104 developmental biology, medicine.anatomical_structure, rhoC GTP-Binding Protein, Trans-Activators, biology.protein, Hepatic stellate cell, Cancer research, PDX1, lcsh:Q, Female, rhoA GTP-Binding Protein, 030217 neurology & neurosurgery, Transcription Factors

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0fcb4591bfa5f4af165770b66785a00Test
https://doi.org/10.1038/s41598-019-43430-0Test

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