Metabolic Effects of Vitamin B1 Therapy under Overnutrition and Undernutrition Conditions in Sheep
| العنوان: | Metabolic Effects of Vitamin B1 Therapy under Overnutrition and Undernutrition Conditions in Sheep |
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| المؤلفون: | Hay Dvir, Guy Van Bommel, Mugagga Kalyesubula, Alexander Rosov, Ramgopal Mopuri |
| المصدر: | Nutrients, Vol 13, Iss 3463, p 3463 (2021) Nutrients Volume 13 Issue 10 |
| بيانات النشر: | MDPI AG, 2021. |
| سنة النشر: | 2021 |
| مصطلحات موضوعية: | Blood Glucose, vitamin B1, Vitamin, obesity, sheep, medicine.medical_specialty, Lipolysis, medicine.medical_treatment, Adipose tissue, Article, body weight, chemistry.chemical_compound, Overnutrition, NEFA, Internal medicine, medicine, Animals, micronutrient therapy, TX341-641, Micronutrients, Thiamine, Saline, Minerals, Nutrition and Dietetics, Nutrition. Foods and food supply, Chemistry, Catabolism, Fatty Acids, Malnutrition, food and beverages, Lipid Metabolism, medicine.disease, Endocrinology, Adipose Tissue, Creatinine, Steatosis, Energy Metabolism, human activities, Biomarkers, Food Science |
| الوصف: | As a precursor for a universal metabolic coenzyme, vitamin B1, also known as thiamine, is a vital nutrient in all living organisms. We previously found that high-dose thiamine therapy prevents overnutrition-induced hepatic steatosis in sheep by enhancing oxidative catabolism. Based on this capacity, we hypothesized that thiamine might also reduce whole-body fat and weight. To test it, we investigated the effects of high-dose thiamine treatment in sheep under overnutrition and calorie-restricted undernutrition to respectively induce positive energy balance (PEB) and negative energy balance (NEB). Eighteen mature ewes were randomly assigned to three treatment groups (n = 6 each). The control group (CG) was administered daily with subcutaneous saline, whereas the T5 and T10 groups were administered daily with equivoque of saline containing 5 mg/kg and 10 mg/kg of thiamine, respectively. Bodyweight and blood biochemistry were measured twice a week for a period of 22 days under PEB and for a consecutive 30 days under NEB. Surprisingly, despite the strong effect of thiamine on liver fat, no effect on body weight or blood glucose was detectable. Thiamine did, however, increase plasma concentration of non-esterified fatty acids (NEFA) during NEB (575.5 ± 26.7, 657.6 ± 29.9 and 704.9 ± 26.1 µEqL−1 for CG, T5, and T10, respectively: p < 0.05), thereby favoring utilization of fatty acids versus carbohydrates as a source of energy. Thiamine increased serum creatinine concentrations (p < 0.05), which paralleled a trending increase in urea (p = 0.09). This may indicate an increase in muscle metabolism by thiamine. Reduction of fat content by thiamine appears more specific to the liver than to adipose tissue. Additional studies are needed to evaluate the potential implications of high-dose vitamin B1 therapy in muscle metabolism. |
| وصف الملف: | application/pdf |
| تدمد: | 2072-6643 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::24afd85e964ea2e924dca1085528cd02Test https://doi.org/10.3390/nu13103463Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....24afd85e964ea2e924dca1085528cd02 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20726643 |
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