Effectiveness of Traditional Chinese Medicineas as an Adjunct Therapy for Refractory Schizophrenia: A Systematic Review and Meta Analysis
| العنوان: | Effectiveness of Traditional Chinese Medicineas as an Adjunct Therapy for Refractory Schizophrenia: A Systematic Review and Meta Analysis |
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| المؤلفون: | Mao-Feng Zhong, Tianhong Zhang, Wan-Fu Lin, Yunxiang Tang, Jijun Wang, YanYan Wei |
| المصدر: | Scientific Reports, Vol 8, Iss 1, Pp 1-9 (2018) Scientific Reports |
| بيانات النشر: | Springer Science and Business Media LLC, 2018. |
| سنة النشر: | 2018 |
| مصطلحات موضوعية: | medicine.medical_specialty, medicine.medical_treatment, lcsh:Medicine, Traditional Chinese medicine, Article, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Brief Psychiatric Rating Scale, Odds Ratio, medicine, Adjuvant therapy, Humans, Medicine, Chinese Traditional, lcsh:Science, Antipsychotic, Clinical Trials as Topic, Multidisciplinary, Positive and Negative Syndrome Scale, business.industry, lcsh:R, Publication bias, medicine.disease, 030227 psychiatry, Treatment Outcome, Schizophrenia, Meta-analysis, lcsh:Q, business, Publication Bias, 030217 neurology & neurosurgery, Antipsychotic Agents, Drugs, Chinese Herbal |
| الوصف: | Although recent studies focused on traditional Chinese medicine (TCM) for the treatment of refractory schizophrenia have reported that it may be beneficial, there is still lack of convincing evidence and critical meta-analytic work regarding its effectiveness as an adjunctive therapy. Therefore, we performed a meta-analysis to investigate the effectiveness of TCM in combination with antipsychotics for refractory schizophrenia. Fourteen articles involving 1725 patients published as of December 2016 were included which compared antipsychotic therapies to either TCM alone, or TCM as an adjunctive therapy. TCM was observed to have beneficial effects on aspects of the Positive and Negative Syndrome Scale (PANSS) including total score changes and negative score changes, as well as clinical effects estimated with PANSS or the Brief Psychiatric Rating Scale (BPRS). The changes in extrapyramidal side effects (RSESE) scores from baseline to the end of the treatment period were similar in two groups of related trials. TCM was also reported to mitigate some anti-psychotic related side-effects and overall, TCM adjuvant therapy was generally safe and well tolerated. While, the results indicated the potential utility of TCM as an alternative adjunctive therapeutic for refractory schizophrenia treatment, there remains a need for further high-quality studies. |
| تدمد: | 2045-2322 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::002940a0a3577c8a92185a2f267cdbb4Test https://doi.org/10.1038/s41598-018-24547-0Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....002940a0a3577c8a92185a2f267cdbb4 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 20452322 |
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