المؤلفون: Hunter, David J, Deveza, Leticia A, Collins, Jamie E, Losina, Elena, Katz, Jeffrey N, Nevitt, Michael C, Lynch, John A, Roemer, Frank W, Guermazi, Ali, Bowes, Michael A, Dam, Erik B, Eckstein, Felix, Kwoh, C Kent, Hoffmann, Steve, Kraus, Virginia B

المصدر: Arthritis Care & Research. 74(7)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Prevention, Biomedical Imaging, Pain Research, Arthritis, Aging, Chronic Pain, Clinical Research, Musculoskeletal, Biomarkers, Cartilage, Articular, Disease Progression, Humans, Knee Joint, Magnetic Resonance Imaging, National Institutes of Health (U.S.), Osteoarthritis, Knee, Synovitis, United States, Public Health and Health Services, Psychology, Clinical sciences, Allied health and rehabilitation science

الوصف: ObjectiveTo determine the optimal combination of imaging and biochemical biomarkers for use in the prediction of knee osteoarthritis (OA) progression.MethodsThe present study was a nested case-control trial from the Foundation of the National Institutes of Health OA Biomarkers Consortium that assessed study participants with a Kellgren/Lawrence grade of 1-3 who had complete biomarker data available (n = 539 to 550). Cases were participants' knees that had radiographic and pain progression between 24 and 48 months compared to baseline. Radiographic progression only was assessed in secondary analyses. Biomarkers (baseline and 24-month changes) that had a P value of

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/64n63926Test

المؤلفون: Kraus, Virginia Byers, Collins, Jamie E, Hargrove, David, Losina, Elena, Nevitt, Michael, Katz, Jeffrey N, Wang, Susanne X, Sandell, Linda J, Hoffmann, Steven C, Hunter, David J

المصدر: Annals of the Rheumatic Diseases. 76(1)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Aging, Chronic Pain, Pain Research, Arthritis, Clinical Research, Musculoskeletal, Aged, Biomarkers, Case-Control Studies, Disease Progression, Female, Humans, Male, Middle Aged, Osteoarthritis, Knee, Pain Measurement, Predictive Value of Tests, Prognosis, ROC Curve, Radiography, Sensitivity and Specificity, Severity of Illness Index, OA Biomarkers Consortium, Disease Activity, Knee Osteoarthritis, Osteoarthritis, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences

الوصف: ObjectiveTo investigate a targeted set of biochemical biomarkers as predictors of clinically relevant osteoarthritis (OA) progression.MethodsEighteen biomarkers were measured at baseline, 12 months (M) and 24 M in serum (s) and/or urine (u) of cases (n=194) from the OA initiative cohort with knee OA and radiographic and persistent pain worsening from 24 to 48 M and controls (n=406) not meeting both end point criteria. Primary analyses used multivariable regression models to evaluate the association between biomarkers (baseline and time-integrated concentrations (TICs) over 12 and 24 M, transposed to z values) and case status, adjusted for age, sex, body mass index, race, baseline radiographic joint space width, Kellgren-Lawrence grade, pain and pain medication use. For biomarkers with adjusted p

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/18b9038bTest

المؤلفون: Roemer, Frank W, Guermazi, Ali, Collins, Jamie E, Losina, Elena, Nevitt, Michael C, Lynch, John A, Katz, Jeffrey N, Kwoh, C Kent, Kraus, Virginia B, Hunter, David J

المصدر: BMC musculoskeletal disorders. 17(1)

مصطلحات موضوعية: Cartilage, Articular, Menisci, Tibial, Bone Marrow, Humans, Osteoarthritis, Knee, Synovitis, Disease Progression, Magnetic Resonance Imaging, Case-Control Studies, Aged, Middle Aged, Female, Male, Osteophyte, Biomarkers, MRI, Osteoarthritis, Progression, Scoring, Chronic Pain, Arthritis, Pain Research, Clinical Research, Musculoskeletal, Clinical Sciences, Orthopedics

الوصف: BackgroundTo describe the scoring methodology and MRI assessments used to evaluate the cross-sectional features observed in cases and controls, to define change over time for different MRI features, and to report the extent of changes over a 24-month period in the Foundation for National Institutes of Health Osteoarthritis Biomarkers Consortium study nested within the larger Osteoarthritis Initiative (OAI) Study.MethodsWe conducted a nested case-control study. Cases (n = 406) were knees having both radiographic and pain progression. Controls (n = 194) were knee osteoarthritis subjects who did not meet the case definition. Groups were matched for Kellgren-Lawrence grade and body mass index. MRIs were acquired using 3 T MRI systems and assessed using the semi-quantitative MOAKS system. MRIs were read at baseline and 24 months for cartilage damage, bone marrow lesions (BML), osteophytes, meniscal damage and extrusion, and Hoffa- and effusion-synovitis. We provide the definition and distribution of change in these biomarkers over time.ResultsSeventy-three percent of the cases had subregions with BML worsening (vs. 66 % in controls) (p = 0.102). Little change in osteophytes was seen over 24 months. Twenty-eight percent of cases and 10 % of controls had worsening in meniscal scores in at least one subregion (p

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3d57p99kTest

المؤلفون: Collins, Jamie E, Losina, Elena, Nevitt, Michael C, Roemer, Frank W, Guermazi, Ali, Lynch, John A, Katz, Jeffrey N, Kwoh, C Kent, Kraus, Virginia B, Hunter, David J

المصدر: Arthritis & Rheumatology. 68(10)

مصطلحات موضوعية: Biomedical and Clinical Sciences, Clinical Sciences, Arthritis, Pain Research, Osteoarthritis, Aging, Chronic Pain, Musculoskeletal, Aged, Arthralgia, Bone Marrow, Bone Marrow Diseases, Cartilage, Articular, Case-Control Studies, Disease Progression, Female, Humans, Knee Joint, Logistic Models, Magnetic Resonance Imaging, Male, Menisci, Tibial, Middle Aged, Multivariate Analysis, Organ Size, Osteoarthritis, Knee, Osteophyte, Radiography, Synovitis, Tibial Meniscus Injuries, Immunology, Public Health and Health Services, Arthritis & Rheumatology, Clinical sciences

الوصف: ObjectiveTo determine the association between changes in semiquantitative magnetic resonance imaging (MRI) biomarkers over 24 months and radiographic and pain progression over 48 months in knees with mild-to-moderate osteoarthritis (OA).MethodsWe undertook a nested case-control study as part of the Foundation for the National Institutes of Health Biomarkers Consortium Project. We used multivariable logistic regression models to examine the association between change over 24 months in semiquantitative MRI markers and radiographic and pain progression in knee OA. MRIs were read according to the MRI OA Knee Score system. We focused on changes in cartilage, osteophytes, meniscus, bone marrow lesions, Hoffa-synovitis, and effusion-synovitis.ResultsThe most parsimonious model included changes in cartilage thickness and surface area, effusion-synovitis, Hoffa-synovitis, and meniscal morphology (C statistic 0.740). Compared with no worsening, worsening in cartilage thickness in ≥3 subregions was associated with 2.8-fold (95% confidence interval [95% CI] 1.3-5.9) greater odds of being a case, and worsening in cartilage surface area in ≥3 subregions was associated with 2.4-fold (95% CI 1.3-4.4) greater odds of being a case. Worsening of meniscal morphology in any region was associated with 2.2-fold (95% CI 1.3-3.8) greater odds of being a case. Worsening effusion-synovitis and Hoffa-synovitis were also associated with a greater odds of being a case (odds ratios 2.7 and 2.0, respectively).ConclusionTwenty-four-month changes in cartilage thickness, cartilage surface area, effusion-synovitis, Hoffa-synovitis, and meniscal morphology were independently associated with OA progression, suggesting that these factors may serve as efficacy biomarkers in clinical trials of disease-modifying interventions for knee OA.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/14n7r761Test

المؤلفون: Losina, Elena, Paltiel, A David, Weinstein, Alexander M, Yelin, Edward, Hunter, David J, Chen, Stephanie P, Klara, Kristina, Suter, Lisa G, Solomon, Daniel H, Burbine, Sara A, Walensky, Rochelle P, Katz, Jeffrey N

المصدر: Arthritis Care & Research. 67(2)

مصطلحات موضوعية: Osteoarthritis, Chronic Pain, Health Services, Pain Research, Arthritis, Aging, Clinical Research, 6.1 Pharmaceuticals, Evaluation of treatments and therapeutic interventions, Musculoskeletal, Good Health and Well Being, Adult, Aged, Arthroplasty, Replacement, Knee, Female, Health Care Costs, Health Services Needs and Demand, Humans, Male, Middle Aged, Models, Economic, Osteoarthritis, Knee, United States, Clinical Sciences, Public Health and Health Services, Psychology

الوصف: ObjectiveThe impact of increasing utilization of total knee arthroplasty (TKA) on lifetime costs in persons with knee osteoarthritis (OA) is understudied.MethodsWe used the Osteoarthritis Policy Model to estimate total lifetime costs and TKA utilization under a range of TKA eligibility criteria among US persons with symptomatic knee OA. Current TKA utilization was estimated from the Multicenter Osteoarthritis Study and calibrated to Health Care Cost and Utilization Project data. OA treatment efficacy and toxicity were drawn from published literature. Costs in 2013 dollars were derived from Medicare reimbursement schedules and Red Book Online. Time costs were derived from published literature and the US Bureau of Labor Statistics.ResultsEstimated average discounted (3% per year) lifetime costs for persons diagnosed with knee OA were $140,300. Direct medical costs were $129,600, with $12,400 (10%) attributable to knee OA over 28 years. OA patients spent a mean ± SD of 13 ± 10 years waiting for TKA after failing nonsurgical regimens. Under current TKA eligibility criteria, 54% of knee OA patients underwent TKA over their lifetimes. Estimated OA-related discounted lifetime direct medical costs ranged from $12,400 (54% TKA uptake) when TKA eligibility was limited to Kellgren/Lawrence grades 3 or 4 to $16,000 (70% TKA uptake) when eligibility was expanded to include symptomatic OA with a lesser degree of structural damage.ConclusionBecause of low efficacy of nonsurgical regimens, knee OA treatment-attributable costs are low, representing a small portion of all costs for OA patients. Expanding TKA eligibility increases OA-related costs substantially for the population, underscoring the need for more effective nonoperative therapies.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/49w7j4fmTest

المؤلفون: Solomon, Daniel H, Tonner, Chris, Lu, Bing, Kim, Seoyoung C, Ayanian, John Z, Brookhart, M Alan, Katz, Jeffrey N, Yelin, Ed

المصدر: Arthritis Care & Research. 66(8)

مصطلحات موضوعية: Arthritis, Autoimmune Disease, Clinical Research, Inflammatory and immune system, Adult, Age Factors, Antirheumatic Agents, Arthritis, Rheumatoid, Female, Hispanic or Latino, Humans, Male, Medication Adherence, Middle Aged, Socioeconomic Factors, Surveys and Questionnaires, Treatment Outcome, White People, Withholding Treatment, Clinical Sciences, Public Health and Health Services, Psychology

الوصف: ObjectiveDisease-modifying antirheumatic drugs (DMARDs) are the standard of care for rheumatoid arthritis (RA); however, studies have found that many patients do not receive them. We examined predictors of starting and stopping DMARDs among a longitudinal cohort of patients with RA.MethodsStudy participants came from a cohort of RA patients recruited from a random sample of rheumatologists' practices in Northern California. We examined patterns and predictors of stopping and starting nonbiologic and biologic DMARDs during 1982-2009 based on annual questionnaires. Stopping was defined as stopping all DMARDs and starting was defined as transitioning from no DMARDs to any DMARDs across 2 consecutive years.ResultsThe analysis of starting DMARDs included 471 subjects with 1,974 pairs of years with no DMARD use in the first of 2 consecutive years. From this population, subjects started DMARD use by year 2 in 313 (15.9%) of the pairs. The analysis of stopping DMARDs included 1,026 subjects with 7,595 pairs of years with DMARD use in the first of 2 consecutive years; in 423 pairs (5.6%), subjects stopped DMARD use by year 2. In models that adjusted for RA-related factors, sociodemographics, and comorbidities, significant predictors of starting DMARDs included younger age, Hispanic ethnicity, shorter disease duration, and the use of oral glucocorticoids. In separate adjusted models, predictors of stopping DMARDs included Hispanic ethnicity and low income, while younger age was associated with a reduced risk of stopping.ConclusionEfforts to improve DMARD use should focus on patient age, ethnicity, and income and RA-related factors.

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/1qj887fmTest

المؤلفون: Yelin, Edward, Tonner, Chris, Kim, Seoyoung C, Katz, Jeffrey N, Ayanian, John Z, Brookhart, M Alan, Solomon, Daniel H

المصدر: Arthritis Care & Research. 66(7)

مصطلحات موضوعية: Aging, Clinical Research, Arthritis, Behavioral and Social Science, Autoimmune Disease, Inflammatory and immune system, Adult, Aged, Antirheumatic Agents, Arthritis, Rheumatoid, Biological Factors, Delivery of Health Care, Female, Humans, Longitudinal Studies, Male, Middle Aged, Socioeconomic Factors, Clinical Sciences, Public Health and Health Services, Psychology

الوصف: ObjectiveTo analyze the effect of sociodemographic, disease, and health system characteristics and contextual features about the community of residence on the subsequent initiation of treatment with biologic agents for rheumatoid arthritis (RA).MethodsWe analyzed data from the University of California, San Francisco Rheumatoid Arthritis Panel Study for the years 1999-2011. Principal data collection was by a structured annual phone survey. We estimated Kaplan-Meier curves of the time until initiation of biologic agents, stratified by age and income. We also used Cox regression to estimate the effect of individual-level sociodemographic and medical factors, contextual-level socioeconomic status measures, and density of health providers in the local community on the probability of initiating therapy with biologic agents for RA.ResultsIn total, 527 persons were included in the panel in 1999, and 229 persons (44%) had initiated therapy with biologic agents by 2011. In multivariable Cox regression models, age

وصف الملف: application/pdf

الوصول الحر: https://escholarship.org/uc/item/3wr1c681Test

المؤلفون: Escalante, Agustín, Barrett, Jane, del Rincón, Inmaculada, Cornell, John E., Phillips, Charlotte B., Katz, Jeffrey N.

المصدر: Medical Care, 2002 Jun 01. 40(6), 451-460.

الوصول الحر: https://www.jstor.org/stable/3768125Test

المؤلفون: Katz, Jeffrey N.

المصدر: Medical Care, 2001 Mar 01. 39(3), 203-205.

الوصول الحر: https://www.jstor.org/stable/3767734Test

المؤلفون: Wright, Elizabeth A., Katz, Jeffrey N., Cisternas, Miriam G., Kessler, Courtenay L., Wagenseller, Aubrey, Losina, Elena

المصدر: Medical Care, 2010 Sep 01. 48(9), 785-791.

الوصول الحر: https://www.jstor.org/stable/25750558Test