Late results of bioabsorbable scaffolds implanted in spontaneous coronary artery dissection evaluated with computed tomography coronary angiography

التفاصيل البيبلوغرافية
العنوان: Late results of bioabsorbable scaffolds implanted in spontaneous coronary artery dissection evaluated with computed tomography coronary angiography
المؤلفون: E Pozo Osinalde, Fernando Macaya, J J Gomez De Diego, S.J Camacho-Freire, Javier Escaned, Nieves Gonzalo, José Moreu, R Gonzalez-Colino, Carlos Macaya, Pablo Salinas, M.R Ortas-Nadal, J.F Diaz-Fernandez, J. Suarez De Lezo, M Massot, David Adlam
المصدر: European Heart Journal. 41
بيانات النشر: Oxford University Press (OUP), 2020.
سنة النشر: 2020
مصطلحات موضوعية: business.industry, medicine.medical_treatment, Ischemia, Percutaneous coronary intervention, medicine.disease, Revascularization, Circumflex branch of left coronary artery, Thrombosis, Restenosis, Right coronary artery, medicine.artery, medicine, Cardiology and Cardiovascular Medicine, Artery dissection, Nuclear medicine, business
الوصف: Background Percutaneous coronary intervention (PCI) in spontaneous coronary artery dissection (SCAD) should be reserved for cases presenting with ongoing extensive ischaemia. Bioresorbable scaffolds (BVS) have emerged as an alternative to avoid permanent stenting, an especially attractive concept for this clinical scenario. However, data of late angiographic outcome of this device in SCAD is lacking. Purpose To evaluate the long-term angiographic outcome of BVS in the setting of SCAD using computed tomography coronary angiography (CTCA) Methods In this multicentre prospective study, high-risk SCAD patients treated with BVS were scheduled for a follow-up CTCA at least 2 years from implantation date. Acquisition was performed according to the current recommendations. All the studies were analysed in a central core laboratory by an independent level 3 expert in CTCA blinded to the clinical and angiographic results. For this purpose, a dedicated software for coronary analysis was used to quantify coronary stenosis and evaluate coronary wall. Results Thirty-four BVS were implanted in 15 SCAD patients (51±12 years-old; 87% female) from 7 different centres in Spain and United Kingdom. The most common presentation was STEMI (n=9, 60%). Target vessels included 11 left anterior descending arteries (73.3%), 3 right coronary arteries (20%) and 1 left circumflex coronary artery (6.7%). One patient received target lesion revascularisation due to scaffold shrinkage in a proximal right coronary artery at 13 months. CTCA was performed 2.4±0.7 years after BVS implantation. No scaffold thrombosis or significant stenosis were detected. Patency of all scaffolds was confirmed with a median luminal area of 5.52 mm2 (IQR: 3.74–6.95) and median stenosis of 11% (IQR: 4–15%). Regarding coronary wall tissue characterization of segments with BVS, there was 32±9.3% of plaque burden and a median plaque volume of 45.3 mm3 (IQR: 26.6–61.9). The most common component of the plaque was fibrous (85±9.4%). Compared to the proximal reference segments, BVS showed more plaque burden (32.2% vs 25.3%; p=0.017) and fibrous percentage (84.7% vs 75.1%; p=0.004) whereas less fibrofatty (6 vs 4.8 mm3; p=0.007) and necrotic volume (0.4 vs 1.2 mm3; p=0.029). BVS segments showed lower absolute minimal luminal area (5.5 vs 8.9 mm2; p=0.004) and diameter (2.7 vs 3.4 mm; p=0.004) compared to the reference segment; however, non-significant differences were seen in percentage stenosis, in keeping with normal vessel tapering. Conclusions In this series of SCAD treated with BVS, scaffolds showed a satisfactory late angiographic outcome, with no significant restenosis and an excellent minimal luminal area and optimal coronary wall healing observed. Funding Acknowledgement Type of funding source: None
تدمد: 1522-9645
0195-668X
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_________::78d290e612ddb836249e37dd163b1fc1Test
https://doi.org/10.1093/ehjci/ehaa946.1738Test
حقوق: OPEN
رقم الانضمام: edsair.doi...........78d290e612ddb836249e37dd163b1fc1
قاعدة البيانات: OpenAIRE