التفاصيل البيبلوغرافية
| العنوان: |
Multi-modality treatment approach for paediatric AVMs with quality-of-life outcome measures. |
| المؤلفون: |
Aziz, Natasha, Duddy, John C., Saeed, Danial, Hennigan, Dawn, Israni, Anil, Puthuran, Mani, Chandran, Arun, Mallucci, Conor |
| المصدر: |
Child's Nervous System; Sep2023, Vol. 39 Issue 9, p2439-2447, 9p |
| مصطلحات موضوعية: |
CHILD patients, STEREOTAXIC techniques, STEREOTACTIC radiosurgery, QUALITY of life, PEDIATRICS, CHILDREN'S hospitals, ARTERIOVENOUS malformation |
| مصطلحات جغرافية: |
UNITED Kingdom |
| مستخلص: |
Purpose: Despite the potentially devastating and permanently disabling effects of paediatric arteriovenous malformations (pAVMs), there is a paucity of studies reporting long-term quality-of-life (QoL) outcomes in AVM patients. We aim to evaluate the management strategies for paediatric intracranial pAVMs in the UK and long-term QoL outcomes using a validated paediatric quality-of-life outcome measure. Methods: In this single-centre case-series, we retrospectively reviewed a prospectively maintained database of all paediatric patients (i.e. 0–18 years old) with intracranial AVMs, who were managed at Alder Hey Children's Hospital from July 2007 to December 2021. We also collected the PedsQL 4.0 score for these patients as a measure of QoL. Results: Fifty-two AVMs were included in our analysis. Forty (80%) were ruptured, 8 (16%) required emergency intervention, 17 (35%) required elective surgery, 15 (30%) underwent endovascular embolisation, and 15 (30%) patients underwent stereotactic radiosurgery. There was an 88% overall obliteration rate. Two (4%) pAVMs rebled, and there were no mortalities. Overall, the mean time from diagnosis to definitive treatment was 144 days (median 119; range 0–586). QoL outcomes were collected for 26 (51%) patients. Ruptured pAVM presentation was associated with worse QoL (p = 0.0008). Location impacted psychosocial scores significantly (71.4, 56.9, and 46.6 for right supratentorial, left supratentorial, and infratentorial, respectively; p = 0.04). Conclusion: This study shows a staged multi-modality treatment approach to pAVMs is safe and effective, with superior obliteration rates with surgery alone. QoL scores are impacted by AVM presentation and location regardless of treatment modality. [ABSTRACT FROM AUTHOR] |
|
Copyright of Child's Nervous System is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
