دورية أكاديمية
Inactive Matrix Gla Protein, Arterial Stiffness, and Endothelia Function in African American Hemodialysis Patients
| العنوان: | Inactive Matrix Gla Protein, Arterial Stiffness, and Endothelia Function in African American Hemodialysis Patients |
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| المؤلفون: | Fain, Mary Ellen, Kapuku, Gaston K., Paulson, William D., Williams, Celestine F., Raed, Anas, Dong, Yanbin, Knapen, Marjo H. J., Vermeer, Cees, Pollock, Norman K. |
| المصدر: | Fain , M E , Kapuku , G K , Paulson , W D , Williams , C F , Raed , A , Dong , Y , Knapen , M H J , Vermeer , C & Pollock , N K 2018 , ' Inactive Matrix Gla Protein, Arterial Stiffness, and Endothelia Function in African American Hemodialysis Patients ' , American Journal of Hypertension , vol. 31 , no. 6 , pp. 735-741 . https://doi.org/10.1093/ajh/hpy049Test |
| سنة النشر: | 2018 |
| المجموعة: | Maastricht University Research Publications |
| مصطلحات موضوعية: | African American, arterial stiffness, blood pressure, chronic kidney disease, endothelial function, hypertension, vitamin K, VITAMIN-K STATUS, CHRONIC KIDNEY-DISEASE, VASCULAR CALCIFICATION, CARDIOVASCULAR EVENTS, DIALYSIS PATIENTS, AORTIC STIFFNESS, RENAL-DISEASE, MORTALITY, CALCIUM, SUPPLEMENTATION |
| الوصف: | BACKGROUND Matrix Gla protein (MGP) is a vascular calcification inhibitor dependent upon vitamin K for activation. Evidence suggests that elevated plasma inactive MGP levels (desphospho-uncarboxylated MGP, dp-ucMGP; indicating poorer vascular vitamin K status) are associated with greater cardiovascular disease (CVD) risk. Despite African Americans experiencing highest rates of kidney failure and CVD events, relationships between dp-ucMGP and CVD risk markers have not been examined in this population. We investigated vascular vitamin K status (via plasma dp-ucMGP) between African American hemodialysis (HD) patients and healthy controls, and the associations of dp-ucMGP with arterial stiffness and endothelial function in HD patients only. METHODS In 37 African American HD patients and 37 age- and race-matched controls, plasma dp-ucMGP was measured by enzyme immunoassay as a marker of vascular vitamin K status. Carotid-femoral pulse wave velocity (PWV; arterial stiffness measurement) and brachial artery flow-mediated dilation (FMD; endothelial function measurement) were assessed by applanation tonometry and ultrasound, respectively, in HD patients only. RESULTS Mean dp-ucMGP levels were 5.6 times higher in HD patients vs. controls (2,139 +/- 1,102 vs. 382 +/- 181 pmol/l, P < 0.01). Multiple linear regression, adjusting for age, sex, dialysis vintage, diabetes mellitus, CVD history, body mass index, and blood pressure, revealed that dp-ucMGP was independently related to PWV (standardized beta = 0.49) and FMD (standardized beta = -0.53) (both P < 0.01). CONCLUSIONS Our data suggest that the higher plasma dp-ucMGP concentrations found in African American HD patients may be associated with greater arterial stiffness and endothelial dysfunction. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| DOI: | 10.1093/ajh/hpy049 |
| الإتاحة: | https://doi.org/10.1093/ajh/hpy049Test https://cris.maastrichtuniversity.nl/en/publications/5deb32bd-b529-42cc-ba36-4352caeed001Test |
| حقوق: | info:eu-repo/semantics/openAccess |
| رقم الانضمام: | edsbas.BC051AFD |
| قاعدة البيانات: | BASE |
| DOI: | 10.1093/ajh/hpy049 |
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