التفاصيل البيبلوغرافية
| العنوان: |
MicroRNA-1185 Promotes Arterial Stiffness though Modulating VCAM-1 and E-Selectin Expression. |
| المؤلفون: |
Haoyuan Deng1, Zhenfeng Song1, Huan Xu1, Xinrui Deng1, Qiao Zhang1, Hongyu Chen1, Yanjiao Wang1, Ying Qin1, Ying Li1,2 liying_helen@163.com |
| المصدر: |
Cellular Physiology & Biochemistry (Karger AG). Jun2017, Vol. 42 Issue 1, p2183-2193. 11p. |
| مصطلحات موضوعية: |
*MICRORNA, *ARTERIAL diseases, *SELECTIN genetics, *CELL adhesion molecules, *VASCULAR cell adhesion molecule-1, *ATHEROSCLEROSIS |
| مستخلص: |
Background/Aims: Atherosclerosis is the primary cause of cardiovascular ischaemic events; arterial stiffness is a characteristic of the atherosclerotic process. MicroRNAs (miRNAs) have been revealed as crucial modulators of atherosclerosis. However, the role of arterial stiffnessrelated miRNAs in the atherosclerotic process is still unclear. Methods: Four hundred six participants from Northern China were enrolled in this study. Circulating miR-1185 and adhesion molecule levels were measured. Multiple linear regression models were used to evaluate the association of miR-1185 levels with brachial-ankle pulse wave velocity (baPWV) and adhesion molecule levels. A mediation analysis was also performed to examine the mediating effect. Cell adhesion molecule levels were measured in primary human umbilical vein endothelial cells (pHUVECs) and human umbilical vein smooth cells (HUVSMCs) transfected with miR-1185 or co-transfected with a miR-1185 inhibitor. Results: miR-1185 was independently correlated with arterial stiffness. A positive relationship between miR-1185 and vascular cell adhesion molecule-1 (VCAM-1) and E-selectin levels was observed. VCAM- 1 and E-selectin partially mediated the correlation between miR-1185 and arterial stiffness. miR-1185 induced a significant increase in the VCAM-1 and E-selectin levels in pHUVECs and HUVSMCs in vitro. According to our mechanistic analysis, VCAM-1 and E-selectin mediated miR-1185-induced arterial stiffening. Conclusions: miR-1185 modulated the expression of VCAM-1 and E-selectin to promote arterial stiffening, suggesting that miR-1185 plays a crucial role in the development of atherosclerosis and may serve as a novel therapeutic target for atherosclerosis. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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