المؤلفون: Corrales, Daniela¹ (AUTHOR) dcorrales@iata.csic.es, Alcántara, Cristina¹ (AUTHOR) crisalba@iata.csic.es, Clemente, María Jesús² (AUTHOR) maria.jesus.clemente@uv.es, Vélez, Dinoraz² (AUTHOR) deni@iata.csic.es, Devesa, Vicenta² (AUTHOR) vdevesa@iata.csic.es, Monedero, Vicente¹ (AUTHOR) btcmon@iata.csic.es, Zúñiga, Manuel¹ (AUTHOR) btcmon@iata.csic.es

المصدر: International Journal of Molecular Sciences. May2024, Vol. 25 Issue 9, p5017. 15p.

مصطلحات موضوعية: *ARSENIC, *ARSENIC poisoning, *LEAD, *HEAVY metals, *ARSENIC compounds, *PHOSPHATES, *METAL ions, *SEMIMETALS

مستخلص: The use of probiotic lactobacilli has been proposed as a strategy to mitigate damage associated with exposure to toxic metals. Their protective effect against cationic metal ions, such as those of mercury or lead, is believed to stem from their chelating and accumulating potential. However, their retention of anionic toxic metalloids, such as inorganic arsenic, is generally low. Through the construction of mutants in phosphate transporter genes (pst) in Lactiplantibacillus plantarum and Lacticaseibacillus paracasei strains, coupled with arsenate [As(V)] uptake and toxicity assays, we determined that the incorporation of As(V), which structurally resembles phosphate, is likely facilitated by phosphate transporters. Surprisingly, inactivation in Lc. paracasei of PhoP, the transcriptional regulator of the two-component system PhoPR, a signal transducer involved in phosphate sensing, led to an increased resistance to arsenite [As(III)]. In comparison to the wild type, the phoP strain exhibited no differences in the ability to retain As(III), and there were no observed changes in the oxidation of As(III) to the less toxic As(V). These results reinforce the idea that specific transport, and not unspecific cell retention, plays a role in As(V) biosorption by lactobacilli, while they reveal an unexpected phenotype for the lack of the pleiotropic regulator PhoP. [ABSTRACT FROM AUTHOR]

المؤلفون: Ullah, Sana¹ (AUTHOR) sana.ullah@lammc.It, Depar, Nizamuddin¹ (AUTHOR), Khan, Dawood¹ (AUTHOR), Memon, Ayaz Ali² (AUTHOR), Ali, Amanat¹ (AUTHOR), Naeem, Asif³ (AUTHOR)

المصدر: Soil & Sediment Contamination. 2024, Vol. 33 Issue 3, p331-352. 22p.

مصطلحات موضوعية: *ARSENIC poisoning, *WHEAT, *GRAIN yields, *GRAIN

مستخلص: This study (pot experiment) investigated and compared the effectiveness of Se(VI) and Se(IV) application at a rate of 1.25 mg Se kg−1 soil on growth, physiology, yield and As uptake by spring wheat on an uncontaminated and As-contaminated (1.5 mg kg−1) soil. Selenate improved wheat grain yield, relative water contents, membrane stability index, total chlorophylls, and antioxidant activities up to 43%, 18.6%, 9.5%, 16.4% and 15–46%, respectively, compared to control under As-contaminated soil. As compared to Se(IV), in accordance with above results, Se(VI) application resulted in 5-fold higher grain Se concentration and 4.4-fold higher grain Se uptake, which are partially explained by 1.3-fold higher root to grain Se translocation factor in Se(VI)-fed plants under As-contaminated soil. Concomitantly, Se(VI) offered a stronger competitive effect on As uptake thereby reducing its concentration in grains by 11% and in shoots by 44%. Translocation factor of As from root to shoots and to grains was 33% and 14.2%, respectively lesser in Se(VI)-fed plants. Thus, it is concluded that Se(VI) application, through its beneficial effects on root morphological traits, improvement in antioxidant activity and physiological behavior, is highly effective in reducing As toxicity on yield and As accumulation in wheat grains. [ABSTRACT FROM AUTHOR]

المؤلفون: Caggìa, Veronica^1,2 veronica.caggia@unibe.ch, Wälchli, Jan², Deslandes-Hérold, Gabriel¹, Mateo, Pierre¹, Robert, Christelle A. M.¹, Hang Guan³, Bigalke, Moritz^3,4, Spielvogel, Sandra^5,6, Mestrot, Adrien³, Schlaeppi, Klaus^1,2 klaus.schlaeppi@unibas.ch, Erba, Matthias¹ matthias.erb@unibe.ch

المصدر: Proceedings of the National Academy of Sciences of the United States of America. 3/26/2024, Vol. 121 Issue 13, p1-10. 58p.

مصطلحات موضوعية: *ARSENIC poisoning, *METABOLITES, *PLANT metabolites, *TRACE elements, *PLANTING

مستخلص: By releasing specialized metabolites, plants modify their environment. Whether and how specialized metabolites protect plants against toxic levels of trace elements is not well understood. We evaluated whether benzoxazinoids, which are released into the soil by major cereals, can confer protection against arsenic toxicity. Benzoxazinoid-producing maize plants performed better in arsenic-contaminated soils than benzoxazinoid-deficient mutants in the greenhouse and the field. Adding benzoxazinoids to the soil restored the protective effect, and the effect persisted to the next crop generation via positive plant--soil feedback. Arsenate levels in the soil and total arsenic levels in the roots were lower in the presence of benzoxazinoids. Thus, the protective effect of benzoxazinoids is likely soil-mediated and includes changes in soil arsenic speciation and root accumulation. We conclude that exuded specialized metabolites can enhance protection against toxic trace elements via soil-mediated processes and may thereby stabilize crop productivity in polluted agroecosystems. [ABSTRACT FROM AUTHOR]

المؤلفون: Anqi Suo¹, Yan Wang², Hongyan Niu³, Xinxin Yang³ yangjnmc@163.com

المصدر: Journal of International Advanced Otology. Mar2024, Vol. 20 Issue 2, p182-185. 4p.

مصطلحات موضوعية: *SENSORINEURAL hearing loss, *ARSENIC poisoning, *ARSENIC, *TOPICAL drug administration, *HEARING disorders, *PANCYTOPENIA

مستخلص: Arsenic is frequently used in alternative medicine, and it is critical to promptly identify and treat suspected arsenic toxicity in patients. In a case study, a female patient presented with several symptoms, including nausea, vomiting, bilateral tinnitus, hearing loss, vertigo, and other associated complaints. After admission, the patient showed lethargy, and topical application of Chinese herbal medicine was found on her left breast, along with visible pigmentation on her torso. Examination revealed severe bilateral sensorineural deafness, liver and kidney injury, and pancytopenia. Due to the presence of broken skin, toxicological analysis detected elevated levels of arsenic in both blood (113 ng/mL) and urine (865.4 ng/mL). The patient was diagnosed with arsenic poisoning and received symptomatic treatment, including detoxification. Unfortunately, the patient died due to long-term exposure to arsenic. Therefore, early identification of the etiology is crucial for managing cases of arsenic poisoning. [ABSTRACT FROM AUTHOR]

المؤلفون: Luo, Mao-Ling¹ (AUTHOR) 20185486@cqu.edu.cn, Chen, Guo-Ying¹ (AUTHOR) 20221801017@stu.cqu.edu.cn, Wang, Jia-Li¹ (AUTHOR) 202118021010@cqu.edu.cn, Chai, Tong-Qing¹ (AUTHOR) 20175531@cqu.edu.cn, Qian, Zheng-Ming² (AUTHOR) qianzhengming@hec.cn, Li, Wen-Jia² (AUTHOR) liwenjia@hec.cn, Yang, Feng-Qing¹ (AUTHOR) liwenjia@hec.cn

المصدر: Molecules. Mar2024, Vol. 29 Issue 5, p1015. 17p.

مصطلحات موضوعية: *ARSENIC, *ARSENIC poisoning, *ARSENIC in water, *FLUORESCENCE quenching, *COPPER ions, *LUMINESCENCE, *FLUORESCENCE

مستخلص: The high toxicity of arsenic (As) can cause irreversible harm to the environment and human health. In this study, the chlorin e6 (Ce6), which emits fluorescence in the infrared region, was introduced as the luminescence center, and the addition of copper ion (Cu2+) and As(V) provoked a regular change in fluorescence at 652 nm, whereas that of As(III) was 665 nm, which was used to optionally detect Cu2+, arsenic (As(III), and As(V)). The limit of detection (LOD) values were 0.212 μM, 0.089 ppm, and 1.375 ppb for Cu2+, As(III), and As(V), respectively. The developed method can be used to determine Cu2+ and arsenic in water and soil with good sensitivity and selectivity. The 1:1 stoichiometry of Ce6 with Cu2+ was obtained from the Job plot that was developed from UV–visible spectra. The binding constants for Cu2+ and As(V) were established to be 1.248 × 105 M−1 and 2.35 × 1012 M−2, respectively, using B–H (Benesi–Hildebrand) plots. Fluorescence lifetimes, B–H plots, FT–IR, and 1H-NMR were used to postulate the mechanism of Cu2+ fluorescence quenching and As(V) fluorescence restoration and the interactions of the two ions with the Ce6 molecule. [ABSTRACT FROM AUTHOR]

المؤلفون: Zhong, Yanhua, Zhang, Wei, Xiao, Hong, Kong, Yijie, Huang, Wenjing, Bai, Danmeng, Yu, Simin, Gao, Jie, Wang, Xiaolei

المصدر: Acta Biomaterialia; Jul2024, Vol. 182, p228-244, 17p

مصطلحات موضوعية: ARSENIC, ARSENIC poisoning, ARSENIC removal (Water purification), CHELATION therapy, RODENTICIDES, MEMBRANE permeability (Biology)

مستخلص: Arsenic (As) poisoning has become a global public problem threatening human health. Chelation therapy (CT) is the preferred treatment for arsenic poisoning. Nevertheless, efficient and safe arsenic removal in vivo remains a daunting challenge due to the limitations of chelators, including weak affinity, poor cell membrane penetration, and short half-life. Herein, a mercapto-functionalized and size-tunable hierarchical porous Zr-MOF (UiO-66-TC-SH) is developed, which possesses abundant arsenic chemisorption sites, effective cell uptake ability, and long half-life, thereby efficiently removing toxic arsenic in vivo. Moreover, the strong binding affinity of UiO-66-TC-SH for arsenic reduces systemic toxicity caused by off-target effects. In animal trials, UiO-66-TC-SH decreases the blood arsenic levels of acute arsenic poisoning mice to a normal value within 48 h, and the efficacy is superior to clinical drugs 2,3-dimercaptopropanesulfonic acid sodium salt (DMPS). Meanwhile, UiO-66-TC-SH also significantly mitigates the arsenic accumulation in the metabolic organs of chronic arsenic poisoning mice. Surprisingly, UiO-66-TC-SH also accelerates the metabolism of arsenic in organs of tumor-bearing mice and alleviates the side effects of arsenic drugs antitumor therapy. Arsenic (As) contamination has become a global problem threatening public health. The present clinical chelation therapy (CT) still has some limitations, including the weak affinity, poor cell membrane permeability and short half-life of hydrophilic chelators. Herein, a metal−organic framework (MOF)-based multieffective arsenic removal strategy in vivo is proposed for the first time. Mercapto-functionalized and size-tunable hierarchical porous Zr-MOF nanoantidote (denoted as UiO-66-TC-SH) is accordingly designed and synthesized. After injection, UiO-66-TC-SH can form Zr− O −As bonds and As− S bonds with arsenic, thus enhancing arsenic adsorption capacity, cycling stability and systemic safety simultaneously. The acute arsenic poisoning model results indicate that UiO-66-TC-SH shows superior efficacy to the clinical drug sodium dimercaptopropanesulfonate (DMPS). More meaningfully, we find that UiO-66-TC-SH also accelerates the metabolism of arsenic in organs of tumor-bearing mice and alleviates side effects of arsenic drugs anti-tumor therapy. [Display omitted] [ABSTRACT FROM AUTHOR]

: Copyright of Acta Biomaterialia is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Shankar, Prabhat, Singh, Rana Vikram, Kumar, Arun

المصدر: Journal of Advanced Zoology; 2024, Vol. 45 Issue 3, p385-393, 9p

مصطلحات موضوعية: SODIUM arsenite, NEPHROTOXICOLOGY, DIETARY supplements, RATS, ARSENIC poisoning, MALONDIALDEHYDE, URIC acid

مستخلص: The presence of arsenic (As) metalloid in groundwater poses serious threat to human and animal’s health. Approx. 300 million people of about 105 countries in the world are affected due to arsenite poisoning. Except mitigation there is no such mode by which the population can be prevented from being exposed to arsenic. Elaeocarpus sphaericus (E. sphaericus) is widely used in the folk medicine system for the treatment of various diseases. Hence, present study aimed to investigate the Bio-remedial Impact of ESSE against As-Induced Nephrotoxicity in Charles foster rats. Male twenty-four rats (weighing 160 ± 20 g) were randomly assigned into two groups, where Group-I (n=6) rats were used as control. Group-II (n=18) rats were treated with sodium arsenite at 8 mg/Kg body weight for 90 days daily and then further divided into three sub-groups. Sub-Group I (n=6); rats were sacrificed and data were collected, Sub-Group II (n=6); rats were left for 60 days for auto recovery (as As-pre-treated group), and Sub-Group II (n=6); rats were administrated with E. sphaericus at 20mg/kg body weight for 60 days. After the completion of entire experimental dose all the control and treatment group were sacrificed to evaluate the various parameters. As-Induced rats had Significant (p<0.0001) alteration in haematological parameters. As-Induced serum levels of urea, uric acid, creatinine and albumin had significant (p<0.0001) alteration. Level of MDA and BUN were significantly (p<0001) increased. However, ESSE administration significantly reduced the adverse effect related to test of nephrological functions, MDA level significantly (p<0.0001) reduced. Dose dependent ESSE administration combat As)Induced toxicity and significantly (P<0.0001) normalise the level of haematological parameters. Hence, the study concluded that E. sphaericus seed might be used as a nutritional supplement to combat the arsenic led toxicity among the exposed population. [ABSTRACT FROM AUTHOR]

: Copyright of Journal of Advanced Zoology is the property of Journal of Advanced Zoology and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Bhat, Abhijnan, Tian, Furong, Singh, Baljit

المصدر: Sensors (14248220); Jun2024, Vol. 24 Issue 12, p3889, 25p

مصطلحات موضوعية: ARSENIC in water, NANOSTRUCTURED materials, ARSENIC poisoning, INSPECTION & review, PUBLIC health, ARSENIC

الشركة/الكيان: WORLD Health Organization, INTERNATIONAL Agency for Research on Cancer

مستخلص: Arsenic, existing in various chemical forms such as arsenate (As(V)) and arsenite (As(III)), demands serious attention in water and environmental contexts due to its significant health risks. It is classified as "carcinogenic to humans" by the International Agency for Research on Cancer (IARC) and is listed by the World Health Organization (WHO) as one of the top 10 chemicals posing major public health concerns. This widespread contamination results in millions of people globally being exposed to dangerous levels of arsenic, making it a top priority for the WHO. Chronic arsenic toxicity, known as arsenicosis, presents with specific skin lesions like pigmentation and keratosis, along with systemic manifestations including chronic lung diseases, liver issues, vascular problems, hypertension, diabetes mellitus, and cancer, often leading to fatal outcomes. Therefore, it is crucial to explore novel, cost-effective, and reliable methods with rapid response and improved sensitivities (detection limits). Most of the traditional detection techniques often face limitations in terms of complexity, cost, and the need for sophisticated equipment requiring skilled analysts and procedures, which thereby impedes their practical use, particularly in resource-constrained settings. Colorimetric methods leverage colour changes which are observable and quantifiable using simple instrumentation or even visual inspection. This review explores the colorimetric techniques designed to detect arsenite and arsenate in water. It covers recent developments in colorimetric techniques, and advancements in the role of nanomaterials in colorimetric arsenic detection, followed by discussion on current challenges and future prospects. The review emphasizes efforts to improve sensitivity, selectivity, cost, and portability, as well as the role of advanced materials/nanomaterials to boost the performance of colorimetric assays/sensors towards combatting this pervasive global health concern. [ABSTRACT FROM AUTHOR]

: Copyright of Sensors (14248220) is the property of MDPI and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Maity, Sourav, Bose, Samprit, Dokania, Puja, Lohar, Sadhana, Sarkar, Angana

المصدر: Environmental Quality Management; Jun2024, Vol. 33 Issue 4, p427-457, 31p

مصطلحات موضوعية: ARSENIC, BIOREMEDIATION, BIOSENSORS, MOLECULAR recognition, ARSENIC poisoning

مصطلحات جغرافية: INDIA

مستخلص: In India, where millions of people use groundwater for drinking, arsenic pollution in groundwater is a major environmental and public health issue. The review begins by analyzing the sources and causes of groundwater arsenic pollution, including natural geological processes and anthropogenic activities like mining and industrial discharge. It emphasizes India's most arsenic‐contaminated regions and the health risks of long‐term exposure. The review's second section focuses on the use of biosensors to find arsenic in groundwater. A potential method is provided by biosensors because of their great sensitivity, selectivity, and quick response. The benefits and drawbacks of several types of biosensors, including optical, electrochemical, and microbiological biosensors, are discussed. The utilization of nanomaterials, biomolecular recognition components, and miniature devices are only a few of the most recent developments in biosensor technology for arsenic detection that are studied. The review's last section discusses methods for bio‐remediating aqueous systems that have been contaminated with arsenic. Various bioremediation techniques are covered in detail, including microbial degradation, phytoremediation, and biosorption. The promise for removing arsenic using native microbes and plant species is highlighted, along with the difficulties of widespread application and long‐term sustainability. Overall, focusing on the detection of arsenic using biosensors and investigating bioremediation techniques, this review offers a thorough grasp of the arsenic poisoning in groundwater in India. In order to combat arsenic contamination and protect the health and wellbeing of the impacted populations in India, it emphasizes the need for interdisciplinary research and collaboration among scientists, engineers, policymakers, and local communities. [ABSTRACT FROM AUTHOR]

: Copyright of Environmental Quality Management is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

المؤلفون: Hardin, Jeremy^1,2,3 (AUTHOR) jrhardin@health.ucsd.edu, Seltzer, Justin^1,2,3 (AUTHOR), Suhandynata, Raymond^4,5 (AUTHOR), Spiegel, Benjamin⁵ (AUTHOR), Silver, Robin⁵ (AUTHOR), Thomas, Diane⁵ (AUTHOR), Galust, Henrik^1,2,3 (AUTHOR), Friedman, Nathan^1,2,3 (AUTHOR), Clark, Richard^1,3 (AUTHOR), Momper, Jeremiah⁵ (AUTHOR)

المصدر: Clinical Case Reports. Jul2023, Vol. 11 Issue 7, p1-7. 7p.

مصطلحات موضوعية: *ARSENIC poisoning, *HEAVY metal toxicology, *LEAD, *ARSENIC

مستخلص: Key Clinical Message: Patients that are taking Ayurvedic supplements have an increased risk of heavy metal toxicity. Lead, arsenic, and mercury are frequently identified in these supplements and can cause clinically significant toxicity. Clinicians should screen patients routinely for use of non‐pharmaceutical medications and supplements. [ABSTRACT FROM AUTHOR]