المؤلفون: de Matos, Veronica S., do Nascimento, Ana L. R., Pereira, Priscila G., Rabelo, Kíssila, Andrade, Cherley B. V., Moraes, Alan C. N., Salata, Camila, Araújo, Victor H. V. de O., Ciambarella, Bianca Torres, Bonfim Vieira, Aline, Alves, Luciana Lontro, da Silva, Jemima F. R., de Carvalho, Jorge J.

المصدر: International Journal of Hypertension; 10/21/2020, p1-13, 13p

مصطلحات موضوعية: ADRENAL gland physiology, AUTOPHAGY, CELL proliferation, ADRENAL glands, ADRENAL diseases, ANIMAL experimentation, APOPTOSIS, ELECTRON microscopy, GENE expression, HYPERTENSION, ANTIHYPERTENSIVE agents, RATS, RENAL artery obstruction, STAINS & staining (Microscopy), RENIN-angiotensin system, ALISKIREN, PHARMACODYNAMICS

مستخلص: Hypertension is a disease classified as primary or secondary, manifested not only by elevation of blood pressure but also involved in structural and functional changes of target organs. Renal artery stenosis is a leading factor of secondary hypertension, and its progress is associated with overactivation of the renin-angiotensin-aldosterone system (RAAS). Aliskiren is a renin inhibiting drug that suppresses RAAS and culminates in decreased renin release, plasma angiotensin II concentration, and inhibition of aldosterone secretion. In this sense, the aim of the present study was to analyze the structural and ultrastructural morphophysiology of the adrenal glomerular zone, after treatment with aliskiren in Wistar rats with 2K1C hypertension. Parameters as structure and ultrastructure of the adrenal glomerular zone, cellular apoptosis, nuclear cell proliferation, and AT1 receptor expression were analyzed by immunostaining and electron microscopy. Our results showed that the hypertensive animals treated with aliskiren presented a reestablishment of AT1 receptor expression and decrease in apoptosis and autophagy. In addition, treatment with aliskiren improves the cell aspects in the adrenal glomerular zone, evidenced by ultrastructural analysis through preserved nuclei and well-developed mitochondria. Therefore, our evidence suggests that aliskiren has a beneficial effect on the adrenal glomerular zone remodeling in animals with renovascular hypertension. [ABSTRACT FROM AUTHOR]

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المؤلفون: Lontro Alves, Luciana¹ (AUTHOR), Gomes Pereira, Priscila¹ (AUTHOR), Torres Ciambarella, Bianca¹ (AUTHOR), Porto Campos, Miguel¹ (AUTHOR), Rabelo, Kíssila^1,2 (AUTHOR), Rosa Nascimento, Ana Lúcia¹ (AUTHOR), Leal de Carvalho dos Santos Cunha, Raíssa¹ (AUTHOR), Borba Vieira Andrade, Cherley¹ (AUTHOR), Cesar Nunes Moraes, Alan^1,3 (AUTHOR), Bernardi, Andressa⁴ (AUTHOR), Verdini Guimarães, Fernanda⁴ (AUTHOR), Fuentes Ribeiro da Silva, Jemima¹ (AUTHOR), José de Carvalho, Jorge¹ (AUTHOR)

المصدر: Journal of Obesity. 5/27/2024, Vol. 2024, p1-14. 14p.

مصطلحات موضوعية: *PHYTOTHERAPY, *NON-alcoholic fatty liver disease, *ADIPOSE tissues, *PLACEBOS, *APOPTOSIS, *BODY composition, *UNSATURATED fatty acids, *OXIDATIVE stress, *MICE, *CHRONIC diseases, *WORLD health, *FATS & oils, *ANIMAL experimentation, *CELL death, *LIVER, *BIOMARKERS

مستخلص: Obesity is a complex chronic disease characterized by excess body fat (adipose) that is harmful to health and has been a major global health problem. It may be associated with several diseases, such as nonalcoholic fatty liver disease (NAFLD). Polyunsaturated fatty acids (PUFA) are lipid mediators that have anti-inflammatory characteristics and can be found in animals and plants, with capybara oil (CO) being a promising source. So, we intend to evaluate the hepatic pathophysiological alterations in C57Bl/6 mice with NAFLD, caused by obesity, and the possible beneficial effects of OC in the treatment of this disease. Eighteen 3-month-old male C57Bl/6 mice received a control or high-fat diet for 18 weeks. From the 15th to the 18th week, the animals received treatment—through orogastric gavage—with placebo or free capybara oil (5 g/kg). Parameters inherent to body mass, glucose tolerance, evaluation of liver enzymes, percentage of hepatic steatosis, oxidative stress, the process of cell death with the apoptotic biomarkers (Bax, Bcl2, and Cytochrome C), and the ultrastructure of hepatocytes were analyzed. Even though the treatment with CO was not able to disassemble the effects on the physiological parameters, it proved to be beneficial in reversing the morphological and ultrastructural damage present in the hepatocytes. Thus, demonstrating that CO has beneficial effects in reducing steatosis and the apoptotic pathway, it is a promising treatment for NAFLD. [ABSTRACT FROM AUTHOR]