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المؤلفون: Valeria Cicatiello, Alfonso Baldi, Eva M. Janssen-Megens, Simon Heath, Olivier A. Bernard, Mariarosaria Conte, Edo Vellenga, Gianluca Sbardella, Alessandra Feoli, Antonello Mai, Francesca Petraglia, Concetta Ingenito, Bowon Kim, Valeria Belsito Petrizzi, Guoqiang Yi, Stefano Tomassi, Abhishek Singh, Angela Nebbioso, Ivo Gut, Paul Flicek, Albertus T. J. Wierenga, Marie-Laure Yaspo, Joost H.A. Martens, Hendrik G. Stunnenberg, Ivana Apicella, Lucia Scisciola, Sergio Valente, Ettore Novellino, Véronique Della Valle, Menotti Ruvo, Sandro De Falco, Amit Mandoli, Colin Logie, Vincenzo Carafa, Lucia Altucci
المساهمون: Università degli studi della Campania 'Luigi Vanvitelli', Radboud university [Nijmegen], Institut de Recherche Vétérinaire de Tunisie (IRVT), Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Ospedale Umberto I, Istituto di Biofisica e Genetica 'Adriano Buzzati Traverso', Consiglio Nazionale delle Ricerche (CNR), Centro Nacional de Analisis Genomico [Barcelona] (CNAG), CNR – Istituto di Biostrutture e Bioimmagini, University Medical Center Groningen [Groningen] (UMCG), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Max Planck Institute for Molecular Genetics (MPIMG), Max-Planck-Gesellschaft, Hématopoïèse normale et pathologique (U1170 Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Sud - Paris 11 (UP11)-Institut Gustave Roussy (IGR), Department of Medicinal Chemistry and Technologies, Institut Pasteur, Fondation Cenci Bolognetti - Istituto Pasteur Italia, Fondazione Cenci Bolognetti, Réseau International des Instituts Pasteur (RIIP)-Réseau International des Instituts Pasteur (RIIP)-Università degli Studi di Roma 'La Sapienza' = Sapienza University [Rome], Università degli studi di Napoli Federico II, Università degli Studi di Salerno (UNISA), Centro Nacional de Análisi Genómico (CNAG), Centro Nacional de Análisis Genómico, This work was supported by BLUEPRINT (282510), Programma VALERE: Vanvitelli per la Ricerca, the Italian-Flag Project-EPIGEN, PRIN-20152TE5PK, the Italian association against cancer (AIRC-17217), the Dutch Cancer Foundation (KWF kun 2011–4937) and Netherlands organization for Scientific Research (NWO-VIDI)., Petraglia, Francesca, Singh, Abhishek A., Carafa, Vincenzo, Nebbioso, Angela, Conte, Mariarosaria, Scisciola, Lucia, Valente, Sergio, Baldi, Alfonso, Mandoli, Amit, Petrizzi, Valeria Belsito, Ingenito, Concetta, De Falco, Sandro, Cicatiello, Valeria, Apicella, Ivana, Janssen-Megens, Eva M., Kim, Bowon, Yi, Guoqiang, Logie, Colin, Heath, Simon, Ruvo, Menotti, Wierenga, Albertus T. J., Flicek, Paul, Yaspo, Marie Laure, Della Valle, Veronique, Bernard, Olivier, Tomassi, Stefano, Novellino, Ettore, Feoli, Alessandra, Sbardella, Gianluca, Gut, Ivo, Vellenga, Edo, Stunnenberg, Hendrik G., Mai, Antonello, Martens, Joost H. A., Altucci, Lucia, Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL)
المصدر: Oncotarget, 9, 39, pp. 25630-25646
Oncotarget
Oncotarget, Impact journals, 2018, 9 (39), pp.25630-25646. ⟨10.18632/oncotarget.25428⟩
Oncotarget 9 (2018): 25630–25646. doi:10.18632/oncotarget.25428
info:cnr-pdr/source/autori:Petraglia F.; Singh A.A.; Carafa V.; Nebbioso A.; Conte M.; Scisciola L.; Valente S.; Baldi A.; Mandoli A.; Petrizzi V.B.; Ingenito C.; De Falco S.; Cicatiello V.; Apicella I.; Janssen-Megens E.M.; Kim B.; Yi G.; Logie C.; Heath S.; Ruvo M.; Wierenga A.T.J.; Flicek P.; Yaspo M.L.; Della Valle V.; Bernard O.; Tomassi S.; Novellino E.; Feoli A.; Sbardella G.; Gut I.; Vellenga E.; Stunnenberg H.G.; Mai A.; Martens J.H.A.; Altucci L./titolo:Combined HAT%2FEZH2 modulation leads to cancer-selective cell death/doi:10.18632%2Foncotarget.25428/rivista:Oncotarget/anno:2018/pagina_da:25630/pagina_a:25646/intervallo_pagine:25630–25646/volume:9
Oncotarget, 9(39), 25630-25646. Impact Journals LLC
Oncotarget, 9, 25630-25646مصطلحات موضوعية: 0301 basic medicine, acetylation, apoptosis, cancer, epigenetics, methylation, oncology, Programmed cell death, [SDV.CAN]Life Sciences [q-bio]/Cancer, 03 medical and health sciences, In vivo, medicine, Molecular Biology, business.industry, Cancer, Epigenetics, Apoptosis, Acetylation, Methylation, EZH2, Apoptosi, Epigenetic, Epigenome, medicine.disease, 3. Good health, Leukemia, 030104 developmental biology, Oncology, Cancer research, business, Ex vivo, Research Paper
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fdda9d466d39d40700157108aaadbeafTest
https://hdl.handle.net/2066/197351Test -
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المؤلفون: Susan Hilgendorf, Edo Vellenga
المساهمون: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL)
المصدر: Haematologica, 103(2), E59-E62. FERRATA STORTI FOUNDATION
مصطلحات موضوعية: Gene knockdown, MUTATIONS, IMPACT, PATHWAYS, Hematology, Biology, CANCER, Phenotype, Malignant transformation, 03 medical and health sciences, Haematopoiesis, 0302 clinical medicine, MUTANTS, Apoptosis, RNA interference, Immunology, ComputingMethodologies_DOCUMENTANDTEXTPROCESSING, MYELODYSPLASTIC SYNDROMES, Cancer research, Gene Knockdown Techniques, Progenitor cell, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries), 030215 immunology
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::effaa4736a7c2759b45b516fcae650f2Test
https://doi.org/10.3324/haematol.2017.173922Test -
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المؤلفون: Jan Jacob Schuringa, Edo Vellenga, Fiona A.J. van den Heuvel, Jennifer Jaques, Roy R Woldhuis, Darlyne S Kluit, Hendrik Folkerts, Albertus T. J. Wierenga
المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS)
المصدر: Cell death & disease, 10(6):421. Nature Publishing Group
Cell Death and Disease, Vol 10, Iss 6, Pp 1-12 (2019)
Cell Death & Diseaseمصطلحات موضوعية: 0301 basic medicine, Cancer Research, Myeloid, Immunology, CD34, Antigens, CD34, Antineoplastic Agents, Apoptosis, Mice, Transgenic, Article, Acute myeloid leukaemia, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, 0302 clinical medicine, Sequestosome-1 Protein, Autophagy, medicine, Animals, Humans, RNA, Small Interfering, lcsh:QH573-671, Progenitor cell, Sulfonamides, lcsh:Cytology, Chemistry, Mitophagy, Membrane Proteins, Myeloid leukemia, Cell Cycle Checkpoints, Mitochondrial Turnover, Cell Biology, Bridged Bicyclo Compounds, Heterocyclic, Fetal Blood, medicine.disease, Mitochondria, Cell biology, Leukemia, Myeloid, Acute, Leukemia, Haematopoiesis, 030104 developmental biology, medicine.anatomical_structure, 030220 oncology & carcinogenesis, Leukocytes, Mononuclear, Female, RNA Interference
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::add3c845b3fb7bc93b0b50b245b55f16Test
https://hdl.handle.net/11370/72cfc471-76ce-4022-a2e3-ff8bd4fc73feTest -
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المؤلفون: Koen Schepers, Jan Jacob Schuringa, Paul J. Coffer, Maria Catalina Gomez-Puerto, Edo Vellenga, Albertus T. J. Wierenga, Hendrik Folkerts
المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS)
المصدر: Stem Cells, 34(6), 1651. AlphaMed Press
STEM CELLS, 34(6), 1651-1663. Wiley-Blackwellمصطلحات موضوعية: 0301 basic medicine, CD34 cells, BONE-MARROW, Cellular differentiation, ATG5, Intracellular Space, CD34, Antigens, CD34, Cell Count, Apoptosis, Biology, Autophagy-Related Protein 7, Autophagy-Related Protein 5, Mice, 03 medical and health sciences, MITOCHONDRIAL CLEARANCE, CD34+cells, Journal Article, Autophagy, Animals, Humans, Progenitor cell, STRESS-RESPONSE, Myeloid Progenitor Cells, Cell Cycle, Cell Differentiation, Hematopoietic stem/progenitor cells, Human cord blood, Cell Biology, Fetal Blood, Hematopoietic Stem Cells, MYELOID-LEUKEMIA CELLS, ARSENIC TRIOXIDE, HUMAN-DISEASE, Cell biology, Haematopoiesis, FATE DECISIONS, DIFFERENTIATION, 030104 developmental biology, Gene Knockdown Techniques, Differentiation, ERYTHROID-CELLS, Molecular Medicine, Stem cell, Reactive Oxygen Species, Developmental Biology
وصف الملف: image/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba6000c3f81d95625b1e3220c0d3316bTest
https://doi.org/10.1002/stem.2347Test -
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المؤلفون: Jan Jacob Schuringa, Matthieu C.J. Bosman, Edo Vellenga
المصدر: Critical Reviews in Oncology/Hematology. 98:35-44
مصطلحات موضوعية: 0301 basic medicine, Acute myeloblastic leukemia, Survival, medicine.medical_treatment, Apoptosis, ACUTE MYELOID-LEUKEMIA, C/EBP-ALPHA ONCOPROTEINS, Translocation, Genetic, 03 medical and health sciences, chemistry.chemical_compound, Paracrine signalling, AML, REFRACTORY MULTIPLE-MYELOMA, medicine, Humans, Molecular Targeted Therapy, Autocrine signalling, ACUTE MYELOGENOUS LEUKEMIA, business.industry, ACUTE MYELOBLASTIC-LEUKEMIA, SINGLE-AGENT CARFILZOMIB, NF-kappa B, Myeloid leukemia, NECROSIS-FACTOR-ALPHA, NF-κB, Hematology, COLONY-STIMULATING FACTOR, Colony-stimulating factor, medicine.disease, Hematopoiesis, Leukemia, Myeloid, Acute, Leukemia, 030104 developmental biology, Cytokine, Oncology, chemistry, Mutation, Immunology, Cancer research, business, RECEPTOR ACCESSORY PROTEIN, STEM-CELLS, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fe5a891ba6cdfa19cfed1c16708a9eeTest
https://doi.org/10.1016/j.critrevonc.2015.10.001Test -
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المؤلفون: Susan, Hilgendorf, Edo, Vellenga
المصدر: Haematologica. 103(2)
مصطلحات موضوعية: Repressor Proteins, Cell Transformation, Neoplastic, Gene Knockdown Techniques, Animals, Humans, Apoptosis, RNA Interference, Tumor Suppressor Protein p53, Hematopoietic Stem Cells, Online Only Articles
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=pmid________::38fd1f6993ea17f3ab0d5dc2e8d4b49cTest
https://pubmed.ncbi.nlm.nih.gov/29101206Test -
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المؤلفون: Matthieu C.J. Bosman, Jan Jacob Schuringa, Annet Z. Brouwers-Vos, Hein Schepers, Jennifer Jaques, Wim J. Quax, Edo Vellenga
المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS), Biopharmaceuticals, Discovery, Design and Delivery (BDDD), Nanotechnology and Biophysics in Medicine (NANOBIOMED)
المصدر: Blood, 124(20), 3130-3140. AMER SOC HEMATOLOGY
مصطلحات موضوعية: EXPRESSION, Myeloid, Stromal cell, TUMOR-CELLS, NF-KAPPA-B, Sialic Acid Binding Ig-like Lectin 3, Immunology, CD34, Apoptosis, ACUTE MYELOID-LEUKEMIA, Biochemistry, Mice, Cancer stem cell, hemic and lymphatic diseases, Cell Line, Tumor, medicine, Animals, Humans, Molecular Targeted Therapy, Progenitor cell, Protein Kinase Inhibitors, Gene Expression Regulation, Leukemic, Chemistry, NF-kappa B, STEM/PROGENITOR CELLS, Myeloid leukemia, Genetic Therapy, Cell Biology, Hematology, MAP Kinase Kinase Kinases, medicine.disease, TAK1 INHIBITION, BETA-ACTIVATED KINASE-1, SELF-RENEWAL, Leukemia, Myeloid, Acute, Leukemia, medicine.anatomical_structure, Gene Knockdown Techniques, SURVIVAL, Cancer research, Female, Stem cell, Transcriptome, STEM-CELLS, Signal Transduction
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a2b12ce08831a43293afe1982876c6eTest
https://doi.org/10.1182/blood-2014-04-569780Test -
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المؤلفون: Susan Hilgendorf, Andre B. Mulder, Albertus T. J. Wierenga, Hendrik Folkerts, Jennifer Jaques, Edo Vellenga, Jan Jacob Schuringa, Paul J. Coffer
المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS)
المصدر: Cell death & disease, 8(7). Nature Publishing Group
Cell death & disease, 8:2927. Nature Publishing Group
Cell Death & Diseaseمصطلحات موضوعية: 0301 basic medicine, Cancer Research, CD34, Antigens, CD34, Apoptosis, Autophagy-Related Protein 7, INITIATING CELLS, Autophagy-Related Protein 5, Mice, Mice, Inbred NOD, hemic and lymphatic diseases, IN-VIVO, bcl-2-Associated X Protein, Gene knockdown, Myeloid leukemia, HISTONE DEACETYLASE INHIBITORS, Leukemia, Myeloid, Acute, Proto-Oncogene Proteins c-bcl-2, ADVANCED SOLID TUMORS, Neoplastic Stem Cells, Female, RNA Interference, Original Article, ATG7, HYDROXYCHLOROQUINE, PROTEINS, ATG5, Immunology, Bone Marrow Cells, Biology, 03 medical and health sciences, Cellular and Molecular Neuroscience, Cell Line, Tumor, Proto-Oncogene Proteins, Autophagy, Journal Article, Animals, Humans, HEMATOPOIETIC STEM-CELLS, neoplasms, THERAPEUTIC TARGET, Wild type, Cell Biology, SELF-RENEWAL, 030104 developmental biology, Cell culture, Cancer research, Tumor Suppressor Protein p53, Apoptosis Regulatory Proteins, Reactive Oxygen Species
وصف الملف: image/pdf; application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a784a0031b44997ebe1f925120cc5c86Test
https://dspace.library.uu.nl/handle/1874/357143Test -
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المؤلفون: Hein Schepers, Gerbrig Berger, Marjan Geugien, Katharina Mattes, Edo Vellenga
المساهمون: Guided Treatment in Optimal Selected Cancer Patients (GUTS), Stem Cell Aging Leukemia and Lymphoma (SALL)
المصدر: Cell death & disease, 8(10):3132. Nature Publishing Group
Cell Death & Diseaseمصطلحات موضوعية: 0301 basic medicine, Cancer Research, CYCLE ARREST, Myeloid, ACETYLATION, Cell Survival, DNA-BINDING, Immunology, NF-KAPPA-B, Apoptosis, ACUTE MYELOID-LEUKEMIA, Biology, Mice, 03 medical and health sciences, Cellular and Molecular Neuroscience, Downregulation and upregulation, DOMAIN, MDM2, AML, Mice, Inbred NOD, Cell Line, Tumor, hemic and lymphatic diseases, medicine, Animals, Humans, Gene knockdown, Myeloid leukemia, Cell Biology, medicine.disease, Repressor Proteins, Leukemia, Myeloid, Acute, Leukemia, BINDING-PROTEIN, 030104 developmental biology, medicine.anatomical_structure, P53-DEPENDENT APOPTOSIS, Cell culture, Trans-Activators, Cancer research, biology.protein, Mdm2, Female, Original Article, Tumor Suppressor Protein p53
وصف الملف: application/pdf
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a472116c43f1d555cfeb9d562f9e396fTest
https://research.rug.nl/en/publications/7504c39a-248e-4fc5-8551-b87cd24919f4Test -
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المؤلفون: Susan Hilgendorf, Edo Vellenga, Hendrik Folkerts, Jan Jacob Schuringa
المساهمون: Stem Cell Aging Leukemia and Lymphoma (SALL), Guided Treatment in Optimal Selected Cancer Patients (GUTS)
المصدر: Experimental Hematology, 44(12), 1188-1196.c6. ELSEVIER SCIENCE INC
Blood, 126(23). AMER SOC HEMATOLOGYمصطلحات موضوعية: 0301 basic medicine, Cancer Research, Myeloid, PROGNOSIS, IMPACT, Cellular differentiation, CD34, Antigens, CD34, Apoptosis, Cell Communication, Biochemistry, Histones, hemic and lymphatic diseases, Cells, Cultured, RISK MYELODYSPLASTIC SYNDROMES, Erythroid Precursor Cells, OUTCOMES, Hematopoietic stem cell, Hematology, Endothelial stem cell, Haematopoiesis, medicine.anatomical_structure, Cord blood, Gene Knockdown Techniques, IDH1, Stem cell, Stromal cell, Immunology, macromolecular substances, FREQUENT, Biology, Colony-Forming Units Assay, 03 medical and health sciences, Genetics, medicine, Humans, Progenitor cell, Molecular Biology, Myeloid Progenitor Cells, MUTATIONS, Mesenchymal stem cell, Mesenchymal Stem Cells, Cell Biology, Hematopoietic Stem Cells, TRANSFORMATION, Repressor Proteins, MICE, 030104 developmental biology, ENHANCED AUTOPHAGY, Cancer research, Bone marrow, Biomarkers, Gene Deletion
الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b9ce28e2a1347475367570fb161128dTest
https://research.rug.nl/en/publications/b2256316-1f5c-458c-b9bf-0157d2806abdTest
