التفاصيل البيبلوغرافية
| العنوان: |
Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways |
| المؤلفون: |
Nagy, Zsuzsanna S., Ross, Jeremy A., Rodriguez, Georgialina, Bader, Julia, Dimmock, Jonathan, Kirken, Robert A. |
| المصدر: |
FEBS Letters; Apr2010, Vol. 584 Issue 8, p1515-1520, 6p |
| مصطلحات موضوعية: |
MEMBRANE proteins, PROTEIN-tyrosine kinases, APOPTOSIS, ENZYME inhibitors, CANCER treatment, GENETIC regulation, INTERLEUKIN-2, PROTEIN microarrays, LYMPHOCYTIC leukemia |
| مستخلص: |
Abstract: In the current work, we report that specific inhibition of Janus tyrosine kinase (JAK3) via NC1153 induces apoptosis of certain leukemia/lymphoma cell lines. Affymetrix microarray profiling following NC1153 treatment unveiled JAK3 dependent survival modulating pathways (p53, TGF-β, TNFR and ER stress) in Kit225 cells. IL-2 responsive NC1153 target genes were regulated in human JAK3 positive, but not in JAK3 negative lymphoid tumor cells. Moreover, primary lymphoma samples revealed that a number of these genes were reciprocally regulated during disease progression and JAK3 inhibition suggesting that downstream targets of JAK3 could be exploited in the development of novel cancer treatment regimes. [Copyright &y& Elsevier] |
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| قاعدة البيانات: |
Complementary Index |
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