التفاصيل البيبلوغرافية
| العنوان: |
Protein-based HDL subspecies: Rationale and association with cardiovascular disease, diabetes, stroke, and dementia. |
| المؤلفون: |
Sacks, F.M.1 (AUTHOR) fsacks@hsph.harvard.edu, Furtado, J.D.2 (AUTHOR) Jfurtado@hsph.harvard.edu, Jensen, M.K.3,4 (AUTHOR) maje@sund.ku.dk |
| المصدر: |
BBA - Molecular & Cell Biology of Lipids. Sep2022, Vol. 1867 Issue 9, pN.PAG-N.PAG. 1p. |
| مصطلحات موضوعية: |
*CARDIOVASCULAR diseases, *HAPTOGLOBINS, *APOLIPOPROTEIN C, *SUBSPECIES, *HIGH density lipoproteins, *CORONARY disease, *DEMENTIA |
| مستخلص: |
HDL-cholesterol is associated with reduced risk of cardiovascular disease, and is used in clinical practice for risk stratification. HDL is composed of many protein-defined subspecies that each comprises just a few percent of the total, some associated with lower and some with higher risk of CVD. HDL that contains apoC3 or apoE are subspecies that have opposing actions on HDL reverse cholesterol transport and opposing associations with risk of future CVD, apoC3 adverse and apoE beneficial. In addition to coronary heart disease, HDL that contains apoC3 is associated with risk of future type 2 diabetes and insulin resistance; ischemic stroke and cerebral infarction; dementia and the deposition of beta-amyloid in the brain. HDL that contains apoE and apoE itself are associated with lower risk of dementia. Other HDL subspecies that contain complement C3, alpha-2 macroglobulin, plasminogen, or haptoglobin are associated with higher future risk of coronary heart disease, whereas others such as HDL that contains apoC1 are associated with lower risk. At this time, these findings provide improved understanding of the multifaceted HDL system to better determine risk and targeting of therapy for the most prevalent chronic lifestyle diseases in our society. • HDL is organized in a multitude of subspecies defined by specific minor proteins. • HDL with apoC3 predicts higher risk of coronary disease, stroke, diabetes, and dementia. • HDL containing apoE is associated with lower risk of coronary disease, dementia, and plaque. • ApoC3 interferes with beneficial functions of HDL apoE on reverse cholesterol transport. • Other HDL subspecies are associated with higher future risk of coronary heart disease, whereas others are associated with lower risk. [ABSTRACT FROM AUTHOR] |
| قاعدة البيانات: |
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