نتائج البحث - "proprotein convertase 9"

1

Potent lipoprotein(a) lowering following apolipoprotein(a) antisense treatment reduces the pro-inflammatory activation of circulating monocytes in patients with elevated lipoprotein(a)

المؤلفون: Renate M. Hoogeveen, Simone L. Verweij, Jeffrey Kroon, Johan G. Schnitzler, Arjen J. Cupido, Mahnoush Bahjat, Lotte C.A. Stiekema, Erik S.G. Stroes, Sotirios Tsimikas, Kim E. Dzobo, Koen H.M. Prange, Menno P.J. de Winther

المساهمون: Graduate School, Vascular Medicine, ACS - Atherosclerosis & ischemic syndromes, Medical Biochemistry, Experimental Vascular Medicine, ACS - Microcirculation, AII - Inflammatory diseases, AGEM - Amsterdam Gastroenterology Endocrinology Metabolism

المصدر: European heart journal, vol 41, iss 24
European heart journal, 41(24), 2262-2271. Oxford University Press

مصطلحات موضوعية: medicine.medical_specialty, Apolipoprotein B, Clinical Sciences, Oligonucleotides, Inflammation, Cardiorespiratory Medicine and Haematology, 030204 cardiovascular system & hematology, PCSK9ab, Cardiovascular, Apoprotein(a), Monocytes, 03 medical and health sciences, 0302 clinical medicine, Internal medicine, Apo(a)-antisense, Gene expression, medicine, Humans, 030212 general & internal medicine, Transcriptomics, biology, business.industry, Lipoprotein(a), Atherosclerosis, Heart Disease, Endocrinology, Cardiovascular System & Hematology, biology.protein, Kexin, Proprotein Convertase 9, medicine.symptom, Antibody, Cardiology and Cardiovascular Medicine, business, Ex vivo, Lipoprotein

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c06540fe5347f3b6185d5d7a2106715dTest
http://www.scopus.com/inward/record.url?scp=85088536364&partnerID=8YFLogxKTest

2

The benign c.344G > A: p.(Arg115His) variant in the LDLR gene interpreted from a pedigree-based genetic analysis of familial hypercholesterolemia

المؤلفون: Mariko Harada-Shiba, Atsushi Takahashi, Cheol Son, Masatsune Ogura, Mika Hori

المصدر: Lipids in Health and Disease, Vol 19, Iss 1, Pp 1-5 (2020)
Lipids in Health and Disease

مصطلحات موضوعية: 0301 basic medicine, Male, Apolipoprotein B, Endocrinology, Diabetes and Metabolism, Annotation, Clinical Biochemistry, Familial hypercholesterolemia, Short Report, 030204 cardiovascular system & hematology, Genetic analysis, Polymorphism, Single Nucleotide, Hyperlipoproteinemia Type II, 03 medical and health sciences, Young Adult, 0302 clinical medicine, Endocrinology, medicine, Humans, Family, Genetic Predisposition to Disease, Variant, Gene, Allele frequency, lcsh:RC620-627, Genetics, biology, PCSK9, Biochemistry (medical), nutritional and metabolic diseases, LDL receptor, Middle Aged, medicine.disease, Pedigree, lcsh:Nutritional diseases. Deficiency diseases, 030104 developmental biology, Receptors, LDL, Benign, biology.protein, Kexin, Female, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9621370bafd29602be542c44726453bfTest
http://link.springer.com/article/10.1186/s12944-020-01252-4Test

3

PCSK9 loss-of-function variants and Lp(a) phenotypes among black US adults

المؤلفون: Vera Bittner, Sotirios Tsimikas, Robert S. Rosenson, Paul Muntner, Mary Cushman, Keri L. Monda, Todd M. Brown, Matthew T. Mefford, Santica M. Marcovina, J. Antonio G. López, Michael E. Farkouh

المصدر: Journal of Lipid Research, Vol 60, Iss 11, Pp 1946-1952 (2019)
Journal of lipid research, vol 60, iss 11
J Lipid Res

مصطلحات موضوعية: 0301 basic medicine, Male, medicine.medical_specialty, Biochemistry & Molecular Biology, Apolipoprotein B, apolipoprotein, Renal function, QD415-436, 030204 cardiovascular system & hematology, Medical Biochemistry and Metabolomics, Cardiovascular, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Loss of Function Mutation, Clinical Research, Internal medicine, medicine, Humans, proprotein convertase subtilisin-kexin type 9, African Americans, biology, business.industry, Oxidized phospholipid, PCSK9, lipoprotein, lipoprotein (a), Cell Biology, Lipoprotein(a), Statin treatment, Middle Aged, Phenotype, United States, Black or African American, 030104 developmental biology, biology.protein, Female, oxidized phospholipids, epidemiology, Biochemistry and Cell Biology, Proprotein Convertase 9, business, Patient-Oriented and Epidemiological Research, Lipoprotein

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c217d833f3b7ea5f98870731b614d60Test
http://www.sciencedirect.com/science/article/pii/S0022227520322926Test

4

Comparative quantitative systems pharmacology modeling of anti-PCSK9 therapeutic modalities in hypercholesterolemia

المؤلفون: Kirill Zhudenkov, Bengt Hamrén, Rasmus Jansson-Löfmark, Eva Hurt-Camejo, Catarina Nilsson, Gabriel Helmlinger, Stanko Skrtic, Kirill Peskov, Victor Sokolov

المصدر: Journal of Lipid Research, Vol 60, Iss 9, Pp 1610-1621 (2019)
Journal of Lipid Research

مصطلحات موضوعية: 0301 basic medicine, Small interfering RNA, Apolipoprotein B, Cholesterol, VLDL, Hypercholesterolemia, QD415-436, 030204 cardiovascular system & hematology, Pharmacology, Antibodies, Monoclonal, Humanized, Biochemistry, 03 medical and health sciences, 0302 clinical medicine, Endocrinology, Humans, Medicine, RNA, Small Interfering, Triglycerides, Apolipoproteins B, plasma proprotein convertase subtilisin/kexin type 9, biology, business.industry, PCSK9, Cholesterol, HDL, Antibodies, Monoclonal, Cholesterol, LDL, Cell Biology, Lipoprotein(a), Models, Theoretical, Proprotein convertase, lipoproteins, quantitative modeling, 030104 developmental biology, Drug development, cholesterol metabolism, biology.protein, Kexin, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, atherosclerosis, translational pharmacology, Patient-Oriented and Epidemiological Research, business, Systems pharmacology

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::db5cee2fd06a636b7abc4f01e227b7dcTest
https://doi.org/10.1194/jlr.m092486Test

5

LDL‐cholesterol and PCSK9 in patients with familial hypercholesterolemia: influence of PCSK9 variants under lipid‐lowering therapy

المؤلفون: Masato Hamasaki, Kazuo Hara, Naoki Sakane, Kazuhiko Kotani

المصدر: Journal of Clinical Laboratory Analysis

مصطلحات موضوعية: Male, Microbiology (medical), medicine.medical_specialty, Apolipoprotein B, PCSK9 inhibitor, gain‐of‐function mutation, lipid‐lowering therapy, Clinical Biochemistry, Familial hypercholesterolemia, statins, Hyperlipoproteinemia Type II, Coronary artery disease, genetic hypercholesterolemia, chemistry.chemical_compound, Internal medicine, medicine, Humans, Immunology and Allergy, Research Articles, Hypolipidemic Agents, biology, Cholesterol, business.industry, PCSK9, Biochemistry (medical), Public Health, Environmental and Occupational Health, Cholesterol, LDL, Hematology, Middle Aged, medicine.disease, Medical Laboratory Technology, low‐density lipoprotein receptor, Endocrinology, chemistry, Mutation, LDL receptor, biology.protein, Kexin, Female, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, business, Research Article, Lipoprotein

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38203a52f17794f9b5c5c6a78c6c6fb1Test
https://doi.org/10.1002/jcla.24056Test

6

The PCSK9 discovery, an inactive protease with varied functions in hypercholesterolemia, viral infections, and cancer

المؤلفون: Nabil G. Seidah

المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100130-(2021)

مصطلحات موضوعية: CHRD, Cys-His-rich domain, Apolipoprotein B, HEK293, human embryonic kidney 293, DENV, dengue virus, Familial hypercholesterolemia, 030204 cardiovascular system & hematology, S1P, site 1 protease, Biochemistry, 0302 clinical medicine, Endocrinology, Thematic Review Series: The Science of FH, Neoplasms, lipid metabolism, GOF, gain-of-function, cancer/metastasis, Receptor, 0303 health sciences, biology, LDLR, LDL receptor, SKI-1, subtilisin-kexin isozyme 1, 3. Good health, Virus Diseases, lipids (amino acids, peptides, and proteins), Proprotein Convertase 9, furin, Endosome, Hypercholesterolemia, QD415-436, FH, familial hypercholesterolemia, ER, endoplasmic reticulum, 03 medical and health sciences, cDNA, complementary DNA, lysosomes, Zymogen, medicine, MHC, major histocompatibility complex, Animals, Humans, mAb, monoclonal antibody, LDL-C, 030304 developmental biology, PCSK9, proprotein convertases, Thematic Review Series, PC, proprotein convertase, Cell Biology, Proprotein convertase, medicine.disease, LDLR, inflammation, LDL receptor, Cancer research, biology.protein, viral infection, PCSK9, proprotein convertase subtilisin/kexin type 9, LOF, loss of function, NARC-1, neural apoptosis-regulated convertase 1

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9b1dcccbf273c1836a23142dd023f3Test
http://europepmc.org/articles/PMC8551645Test

7

A phenome-wide association study of genetically mimicked statins

المؤلفون: Shun Li, Catherine Mary Schooling

المصدر: BMC Medicine
BMC Medicine, Vol 19, Iss 1, Pp 1-11 (2021)

مصطلحات موضوعية: Male, Phenome-wide association study, medicine.medical_specialty, Apolipoprotein B, 030204 cardiovascular system & hematology, 03 medical and health sciences, chemistry.chemical_compound, 0302 clinical medicine, Sex hormone-binding globulin, Ezetimibe, Internal medicine, Mendelian randomization, Humans, Medicine, 030212 general & internal medicine, Mean platelet volume, Sex-specific analysis, biology, business.industry, Anticholesteremic Agents, PCSK9, Statins, Cholesterol, LDL, General Medicine, Mendelian Randomization Analysis, Endocrinology, chemistry, Basal metabolic rate, biology.protein, Female, Calcium, lipids (amino acids, peptides, and proteins), Glycated hemoglobin, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Proprotein Convertase 9, business, Research Article, medicine.drug

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::de2c88c1f1663487b851351f92c5168eTest
https://doi.org/10.1186/s12916-021-02013-5Test

8

Atherosclerosis-associated hepatic secretion of VLDL but not PCSK9 is dependent on cargo receptor protein Surf4

المؤلفون: Yishi Shen, Shucun Qin, Bingxiang Wang, Yongfang Zhao, Lei Zhai, Boyan Liu, Xiaole Chang, Adekunle Alabi, Shijun Deng, Maggie Wang, Hong-mei Gu, Da-Wei Zhang, Xiao-dan Xia, Guiqing Wang, Sijie Xing

المصدر: Journal of Lipid Research
Journal of Lipid Research, Vol 62, Iss, Pp 100091-(2021)

مصطلحات موضوعية: 0301 basic medicine, Alb, albumin, Very low-density lipoprotein, Apolipoprotein B, TANGO1, Transport and Golgi Organization 1, 030204 cardiovascular system & hematology, Lipoproteins, VLDL, Biochemistry, Microsomal triglyceride transfer protein, apoB100, chemistry.chemical_compound, Mice, 0302 clinical medicine, Endocrinology, AAV, adeno-associated virus, stearyl-CoA-1, lipid metabolism, COPII, classical coat protein complex II, Cells, Cultured, lipoprotein metabolism, Mice, Knockout, apoB, apolipoprotein B, biology, CE, cholesteryl ester, TG, triglyceride, LDLR, LDL receptor, Surf4, Surfeit 4, MTP, microsomal triglyceride transfer protein, Lipogenesis, Cholesteryl ester, lipids (amino acids, peptides, and proteins), ASCVD, atherosclerotic cardiovascular disease, Proprotein Convertase 9, Research Article, medicine.medical_specialty, apoB100, apolipoprotein B100, QD415-436, liver, LDL, 03 medical and health sciences, Internal medicine, ALT, alanine aminotransferase, medicine, Animals, Secretion, triglyceride, Cholesterol, Surf4LKO, Surf4 liver-specific knockout, nutritional and metabolic diseases, Membrane Proteins, SCD1, stearoyl-CoA desaturase-1, Cell Biology, Atherosclerosis, TC, total cholesterol, Mice, Inbred C57BL, 030104 developmental biology, LDLR, chemistry, Receptors, LDL, LDL receptor, biology.protein, VTV, VLDL transport vesicle, apolipoproteins, PCSK9, proprotein convertase subtilisin/kexin type 9

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ace96902105c8bd0f6e5ca427b95574Test
http://europepmc.org/articles/PMC8261665Test

9

Lipoprotein(a) in hereditary hypercholesterolemia: Influence of the genetic cause, defective gene and type of mutation

المؤلفون: Victoria Marco-Benedí, Itziar Lamiquiz-Moneo, Pilar Calmarza, Núria Plana, Ana Cenarro, César Martín, Xavier Pintó, Ana M. Bea, Martín Laclaustra, Fernando Civeira, Estíbaliz Jarauta, Asier Larrea-Sebal

المساهمون: Ministerio de Ciencia, Innovación y Universidades (España), Agencia Estatal de Investigación (España), Centro de Investigación Biomédica en Red Enfermedades Cardiovaculares (España), Gobierno de Aragón, European Commission

المصدر: Atherosclerosis. 349

وصف الملف: application/pdf

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::194401868cd1f2a890226ce55ea75208Test
https://pubmed.ncbi.nlm.nih.gov/34456049Test

10

The size of apolipoprotein (a) is an independent determinant of the reduction in lipoprotein (a) induced by PCSK9 inhibitors

المؤلفون: Friederike Schumann, Elisabeth Steinhagen-Thiessen, Stefan Coassin, Gilles Lambert, Mikaël Croyal, Clément Chong Hong-Fong, Tim Hollstein, Kévin Chemello, Thomas Grenkowitz, Brice Nativel, Claudia Lamina, Ursula Kassner, Valentin Blanchard

المصدر: Cardiovascular research. 118(9)

الوصول الحر: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc8e03222d45de7bd0818429c9231df4Test
https://pubmed.ncbi.nlm.nih.gov/34314498Test

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