التفاصيل البيبلوغرافية
| العنوان: |
Longitudinal study of echocardiography-derived tricuspid regurgitant jet velocity in sickle cell disease. |
| المؤلفون: |
Desai, Payal C., May, Ryan C., Jones, Susan K., Strayhorn, Dell, Caughey, Melissa, Hinderliter, Alan, Ataga, Kenneth I. |
| المصدر: |
British Journal of Haematology; Sep2013, Vol. 162 Issue 6, p836-841, 6p, 3 Charts, 2 Graphs |
| مصطلحات موضوعية: |
LONGITUDINAL method, ECHOCARDIOGRAPHY, TRICUSPID valve, SICKLE cell anemia treatment, AORTIC valve insufficiency, BIOMARKERS, ANGIOTENSINS, THERAPEUTICS |
| مستخلص: |
Although echocardiography-derived tricuspid regurgitant jet velocity ( TRV) is associated with increased mortality in sickle cell disease ( SCD), its rate of increase and predictive markers of its progression are unknown. We evaluated 55 subjects (median age: 38 years, range: 20-65 years) with at least two measurable TRVs, followed for a median of 4·5 years (range: 1·0-10·5 years) in a single-centre, prospective study. Thirty-one subjects (56%) showed an increase in TRV, while 24 subjects (44%) showed no change or a decrease in TRV. A linear mixed effects model indicated an overall rate of increase in the TRV of 0·02 m/s per year ( P = 0·023). The model showed that treatment with hydroxycarbamide was associated with an initial TRV that was 0·20 m/s lower than no such treatment ( P = 0·033), while treatment with angiotensin converting enzyme inhibitors and angiotensin receptor blockers was associated with an increase in the TRV ( P = 0·006). In summary, although some patients have clinically meaningful increases, the overall rate of TRV increase is slow. Treatment with hydroxycarbamide may decrease the progression of TRV. Additional studies are required to determine the optimal frequency of screening echocardiography and the effect of therapeutic interventions on the progression of TRV in SCD. [ABSTRACT FROM AUTHOR] |
|
Copyright of British Journal of Haematology is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
