التفاصيل البيبلوغرافية
| العنوان: |
Cyclooxygenase-2 Inhibition Attenuates Abdominal Aortic Aneurysm Progression in Hyperlipidemic Mice. |
| المؤلفون: |
Ghoshal, Sarbani1 (AUTHOR), Loftin, Charles D.1 (AUTHOR) cdloft2@email.uky.edu |
| المصدر: |
PLoS ONE. Nov2012, Vol. 7 Issue 11, Special section p1-10. 10p. |
| مصطلحات موضوعية: |
*ABDOMINAL aortic aneurysms, *AORTIC aneurysms, *AORTIC rupture, *CYCLOOXYGENASE 2, *CELECOXIB, *INFLAMMATION, *BIOMARKERS |
| مستخلص: |
Abdominal aortic aneurysms (AAAs) are a chronic inflammatory disease that increase the risk of life-threatening aortic rupture. In humans, AAAs have been characterized by increased expression of cyclooxygenase-2 and the inactivation of COX-2 prior to disease initiation reduces AAA incidence in a mouse model of the disease. The current study examined the effectiveness of selective cyclooxygenase-2 (COX-2) inhibition on reducing AAA progression when administered after the initiation of AAA formation. AAAs were induced in hyperlipidemic apolipoprotein E-deficient mice by chronic angiotensin II (AngII) infusion and the effect of treatment with the COX-2 inhibitor celecoxib was examined when initiated at different stages of the disease. Celecoxib treatment that was started 1 week after initiating AngII infusion reduced AAA incidence by 61% and significantly decreased AAA severity. Mice treated with celecoxib also showed significantly reduced aortic rupture and mortality. Treatment with celecoxib that was started at a late stage of AAA development also significantly reduced AAA incidence and severity. Celecoxib treatment significantly increased smooth muscle alpha-actin expression in the abdominal aorta and did not reduce expression of markers of macrophage-dependent inflammation. These findings indicate that COX-2 inhibitor treatment initiated after formation of AngII-induced AAAs effectively reduces progression of the disease in hyperlipidemic mice. [ABSTRACT FROM AUTHOR] |
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