التفاصيل البيبلوغرافية
| العنوان: |
Perylene‐Based Reactive Oxygen Species Supergenerator for Immunogenic Photochemotherapy against Hypoxic Tumors. |
| المؤلفون: |
Lou, Xue, Wang, Hui, Liu, Yu, Huang, Yongwei, Liu, Zhonghua, Zhang, Wei, Wang, Tie |
| المصدر: |
Angewandte Chemie; 3/6/2023, Vol. 135 Issue 11, p1-11, 11p |
| مصطلحات موضوعية: |
PHOTOCHEMOTHERAPY, REACTIVE oxygen species, PHOTODYNAMIC therapy, CHARGE exchange, ENERGY transfer, TUMORS |
| مستخلص: |
Reactive oxygen species (ROS) can act as cytotoxic radicals to directly kill tumor cells and concurrently trigger immunogenic cell death (ICD) to efficiently achieve tumor therapy. Thus motivated, we herein present one perylene monoamide‐based ROS supergenerator (PMIC‐NC) that not only induces hypoxia‐enhanced Type‐I ROS burst aided by proton transients but also triggers Type‐I/II ROS production by electron or energy transfer under near‐infrared (NIR) light irradiation and also elicits a strong ICD effect. More interesting, the mitochondria‐ and lung‐specific distribution of PMIC‐NC also boosts the tumor therapeutic efficiency. As a result, PMIC‐NC was employed for NIR‐triggered photodynamic therapy, hypoxia‐enhanced chemotherapy and also displayed robust immunogenicity for systemic tumor eradication. This work thus contributes one proof‐of‐concept demonstration of perylene as an integrated therapeutic platform for efficient immunogenic photochemotherapy against hypoxic tumors. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
