التفاصيل البيبلوغرافية
| العنوان: |
Immune reconstitution after single-unit umbilical cord blood transplantation using anti-thymoglobulin and myeloablative conditioning in adults with hematological malignancies. |
| المؤلفون: |
Cordón, Lourdes, Chorão, Pedro, Martín-Herreros, Beatriz, Montoro, Juan, Balaguer, Aitana, Guerreiro, Manuel, Villalba, Marta, Facal, Ana, Asensi, Pedro, Solves, Pilar, Gómez, Inés, Santiago, Marta, Lamas, Brais, Bataller, Ana, Granados, Pablo, Sempere, Amparo, Sanz, Guillermo F., Sanz, Miguel A., Sanz, Jaime |
| المصدر: |
Annals of Hematology; Jul2024, Vol. 103 Issue 7, p2475-2484, 10p |
| مصطلحات موضوعية: |
CORD blood transplantation, HEMATOLOGIC malignancies, T cells, KILLER cells, ADULTS |
| مستخلص: |
This study aimed to investigate the kinetics of immune recovery following umbilical cord blood transplantation (UCBT) in adults who received a myeloablative conditioning (MAC) regimen and antithymocyte globulin (ATG). While the immune recovery kinetics has been extensively studied in pediatric UCBT recipients, limited data exist for adults. We conducted a comprehensive analysis of 221 consecutive adult patients who underwent UCBT with MAC and ATG at a single institution. Our objective was to evaluate the influence of patient, disease, and transplant factors, along with acute graft-versus-host disease (aGVHD), on immune reconstitution and overall survival. Our findings confirm a delayed recovery of T cells, while B and NK cell reconstitution exhibited rapid progress, with NK cell counts reaching normal levels within 3 months post-transplantation and B cells within 6 months. Within CD3+ T cells, CD8+ T cells also experienced a delayed recovery (12 months), but to a lesser extent compared to CD4+ T cells (18 months). Delayed immune recovery of T-cell subsets was associated with the development of aGVHD grade II-IV, older age, CMV negativity, and a female donor. Patients with lymphoproliferative diseases showed slower NK cell recovery. Our study demonstrates that adult patients undergoing MAC with ATG and receiving a single unit UCBT for hematologic malignancies experienced rapid reconstitution of NK and B cells. However, T cell recovery, particularly CD4+ T cells, was significantly delayed. To enhance T cell recovery, it may be crucial to consider UCB units with higher cellularity and optimize ATG doses in conditioning. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
Complementary Index |
