Are Antipsychotic Prescribing Patterns Different in Older and Younger Adults?: A Survey of 1357 Psychiatric Inpatients in Toronto
| العنوان: | Are Antipsychotic Prescribing Patterns Different in Older and Younger Adults?: A Survey of 1357 Psychiatric Inpatients in Toronto |
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| المؤلفون: | Benoit H. Mulsant, Beth Sproule, Jennifer Lake, David C. Mamo, Hiroyuki Uchida |
| المصدر: | The Canadian Journal of Psychiatry. 55:248-254 |
| بيانات النشر: | SAGE Publications, 2010. |
| سنة النشر: | 2010 |
| مصطلحات موضوعية: | Adult, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, MEDLINE, Drug Prescriptions, Pharmacy records, Young Adult, Pharmacotherapy, medicine, Humans, Drug Dosage Calculations, Antipsychotic drugs, Young adult, Child, Antipsychotic, Psychiatry, music, Aged, Aged, 80 and over, Ontario, Inpatients, Drugs -- Prescribing, Mood Disorders, business.industry, Age Factors, Middle Aged, music.record_label, Drug Dosage Calculation, Psychiatry and Mental health, Mood, Psychotic Disorders, Younger adults, Female, business, Antipsychotic Agents |
| الوصف: | Objective: To compare antipsychotic prescribing patterns in younger (aged 59 years or younger) and older (aged 60 years or older) patients with psychotic or mood disorders. Method: Pharmacy records of all patients discharged from the Centre for Addiction and Mental Health over a 21-month period were reviewed. A total of 1357 patients who were prescribed an antipsychotic at the time of their discharge were included in the analysis (956 with a primary psychotic disorder and 401 with a primary mood disorder). World Health Organization-defined daily doses were used as the standardized dosing unit. Results: Both in patients with a primary psychotic disorder and in patients with a primary mood disorder, the prescribing patterns were similar in older and younger patients, with no statistical difference in the proportions receiving first-generation antipsychotics, second-generation antipsychotics (SGAs), multiple antipsychotics, or long-acting (depot) antipsychotics. Overall, the mean daily antipsychotic doses were lower only in the older group of patients with a primary mood disorder. However, the mean dose of SGAs was about 30% lower in older patients in both diagnostic groups. Regardless of age, patients with a mood disorder were prescribed lower doses of antipsychotics than those with a psychotic disorder. Conclusions: Our data suggest that older patients are prescribed lower antipsychotic dosages primarily when using SGAs. This finding emphasizes the need for dose-finding studies assessing both the efficacy and the safety of antipsychotics in older patients with a psychotic or mood disorder. peer-reviewed |
| تدمد: | 1497-0015 0706-7437 |
| الوصول الحر: | https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd50e728b0cbf5ad254620464a37c2e8Test https://doi.org/10.1177/070674371005500408Test |
| حقوق: | OPEN |
| رقم الانضمام: | edsair.doi.dedup.....fd50e728b0cbf5ad254620464a37c2e8 |
| قاعدة البيانات: | OpenAIRE |
| تدمد: | 14970015 07067437 |
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