التفاصيل البيبلوغرافية
| العنوان: |
The role of hyaluronic acid and hyaluronidase-1 in obstructive sleep apnoea. |
| المؤلفون: |
Meszaros, Martina, Kis, Adrian, Kunos, Laszlo, Tarnoki, Adam Domonkos, Tarnoki, David Laszlo, Lazar, Zsofia, Bikov, Andras |
| المصدر: |
Scientific Reports; 11/10/2020, Vol. 10 Issue 1, pN.PAG-N.PAG, 1p |
| مصطلحات موضوعية: |
HYALURONIC acid, HYALURONIDASES, SLEEP apnea syndromes, MOLECULAR weights, INFLAMMATION, ANTIOXIDANTS |
| مستخلص: |
Biological functions of hyaluronic acid (HA) depend on its molecular size. High-molecular weight HA (HMW-HA) is an important component of the endothelial wall and has anti-inflammatory and antioxidant properties. Under inflammation or hypoxia, HMW-HA is degraded by hyaluronidases, such as HYAL-1 resulting in pro-inflammatory low-molecular weight fragments. Obstructive sleep apnoea (OSA) is characterised by intermittent hypoxia and systemic inflammation. Our aim was to evaluate circulating HMW-HA and HYAL-1 in OSA. We recruited 68 patients with OSA and 40 control volunteers. After full-night sleep study blood samples were taken for HMW-HA and HYAL-1 measurements. HYAL-1 levels were significantly higher in patients with OSA compared to controls (0.59/0.31–0.88/ng/mL vs. 0.31/0.31–0.58/ng/mL; p = 0.005) after adjustment for gender, age, BMI and smoking. There was a trend for reduced HMW-HA concentrations in OSA (31.63/18.11–59.25/ng/mL vs. 46.83/25.41–89.95/ng/mL; p = 0.068). Significant correlation was detected between circulating HMW-HA and apnoea-hypopnoea-index (r = − 0.195, p = 0.043), HYAL-1 and apnoea-hypopnoea-index (r = 0.30, p < 0.01) as well as oxygen desaturation index (r = 0.26, p < 0.01). Our results suggest that chronic hypoxia is associated with increased plasma HYAL-1 concentration and accelerated HMW-HA degradation. Altered hyaluronan metabolism may be involved in the inflammatory cascade potentially leading to endothelial dysfunction in OSA. [ABSTRACT FROM AUTHOR] |
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| قاعدة البيانات: |
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