التفاصيل البيبلوغرافية
| العنوان: |
Hepatoprotective Screening of Seriphidium kurramense (Qazilb.) Y.R. Ling. |
| المؤلفون: |
Ali, Maroof, Hussain, Hidayat, Hussain, Amjad, Rauf, Abdur, Hussain, Wahid, Ullah, Manzoor, Abbas, Safdar, Al-Awthan, Yahya S., Bahattab, Omar, Khan, Muhammad, Olatunde, Ahmed, Almarhoon, Zainab M., Mabkhot, Yahia N., Alshehri, Mohammed M., Daştan, Sevgi Durna, Ramadan, Mohamed Fawzy, Sharifi-Rad, Javad |
| المصدر: |
BioMed Research International; 12/6/2021, p1-11, 11p |
| مصطلحات موضوعية: |
GLUTATHIONE, MEDICINAL plants, DNA, ANIMAL experimentation, SUPEROXIDE dismutase, ANTIOXIDANTS, HEALTH outcome assessment, HYDROCARBONS, HEPATOTOXICOLOGY, RATS, OXIDATIVE stress, MALONDIALDEHYDE, DESCRIPTIVE statistics, PLANT extracts, NITRIC oxide, ALANINE aminotransferase, ASPARTATE aminotransferase |
| مستخلص: |
Investigation on medicinal plants' therapeutic potential has gained substantial importance in the discovery of novel effective and safe therapeutic agents. The present study is aimed at investigating the hepatoprotective potential of Seriphidium kurramense methanolic extract (SKM) against carbon tetrachloride- (CCl4-) induced hepatotoxicity in rats. S. kurramense is one of the most imperative plants for its various pharmacological activities. Therefore, this study was aimed at evaluating the hepatoprotective potential against CCl4-induced liver toxicity. The serum samples were analyzed for alanine aminotransferase (ALT) and aspartate aminotransferase (AST) together with the oxidative stress mediator levels as nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), reduced glutathione (GSH), and superoxide dismutase (SOD) as well as peroxidation and H2O2 activity. CCl4 administration resulted in an elevated free radical generation, altered liver marker (AST and ALT) enzymes, reduced antioxidant enzyme, and increased DNA damage. Methanolic extract of S. kurramense decreased CCl4-induced hepatotoxicity by increasing the antioxidant status and reducing H2O2 and nitrate content generation as well as reducing DNA damage. Additionally, SKM reversed the morphological alterations induced by CCl4 in the SKM-treated groups. These results demonstrated that SKM displayed hepatoprotective activity against CCl4-induced hepatic damage in experimental rats. [ABSTRACT FROM AUTHOR] |
|
Copyright of BioMed Research International is the property of Hindawi Limited and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| قاعدة البيانات: |
Complementary Index |
Full Text Finder