دورية أكاديمية
A Study on the Planarian Model Confirms the Antioxidant Properties of Tameron against X-ray- and Menadione-Induced Oxidative Stress
| العنوان: | A Study on the Planarian Model Confirms the Antioxidant Properties of Tameron against X-ray- and Menadione-Induced Oxidative Stress |
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| المؤلفون: | Elena Tsarkova, Kristina Filippova, Vera Afanasyeva, Olga Ermakova, Anastasia Kolotova, Artem Blagodatski, Artem Ermakov |
| المصدر: | Antioxidants, Vol 12, Iss 4, p 953 (2023) |
| بيانات النشر: | MDPI AG |
| سنة النشر: | 2023 |
| المجموعة: | Directory of Open Access Journals: DOAJ Articles |
| مصطلحات موضوعية: | planarians, Tameron, antioxidant, regeneration, radioprotection, Therapeutics. Pharmacology, RM1-950 |
| الوصف: | Ionizing radiation and radiation-related oxidative stress are two important factors responsible for the death of actively proliferating cells, thus drastically reducing the regeneration capacity of living organisms. Planarian flatworms are freshwater invertebrates that are rich in stem cells called neoblasts and, therefore, present a well-established model for studies on regeneration and the testing of novel antioxidant and radioprotective substances. In this work, we tested an antiviral and antioxidant drug Tameron (Monosodium α-Luminol or 5-amino-2,3-dihydro-1,4-phthalazinedione sodium salt) for its ability to reduce the harm of X-ray- and chemically induced oxidative stress on a planarian model. Our study has revealed the ability of Tameron to effectively protect planarians from oxidative stress while enhancing their regenerative capacity by modulating the expression of neoblast marker genes and NRF-2-controlled oxidative stress response genes. |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 2076-3921 |
| العلاقة: | https://www.mdpi.com/2076-3921/12/4/953Test; https://doaj.org/toc/2076-3921Test; https://doaj.org/article/14ad227be0f74ceaae99c1532956dcb4Test |
| DOI: | 10.3390/antiox12040953 |
| الإتاحة: | https://doi.org/10.3390/antiox12040953Test https://doaj.org/article/14ad227be0f74ceaae99c1532956dcb4Test |
| رقم الانضمام: | edsbas.A70B499A |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 20763921 |
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| DOI: | 10.3390/antiox12040953 |