دورية أكاديمية
Role of urine immunofixation in the complete response assessment of MM patients other than light-chain-only disease.
| العنوان: | Role of urine immunofixation in the complete response assessment of MM patients other than light-chain-only disease. |
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| المؤلفون: | Lahuerta, Juan-José, Jiménez-Ubieto, Ana, Paiva, Bruno, Martínez-López, Joaquín, González-Medina, José, López-Anglada, Lucía, Cedena, María-Teresa, Puig, Noemi, Oriol, Albert, Blanchard, María-Jesús, Ríos, Rafael, Martin, Jesús, Martínez, Rafael, Sureda, Anna, Hernández, Miguel Teodoro, de la Rubia, Javier, Krsnik, Isabel, Cabañas, Valentín, Palomera, Luis, Bargay, Joan, Mateos, María-Victoria, Rosiñol, Laura, San Miguel, Jesús F, Blade, Joan |
| سنة النشر: | 2019 |
| المجموعة: | Sistema Sanitario Público de Andalucía (SSPA): Repositorio |
| مصطلحات موضوعية: | Adult, Aged, Antineoplastic Combined Chemotherapy Protocols, Electrophoresis, Female, Humans, Male, Middle Aged, Multiple Myeloma, Myeloma Proteins, Randomized Controlled Trials as Topic, Treatment Outcome |
| الوصف: | Response criteria for multiple myeloma (MM) require monoclonal protein (M-protein)-negative status on both serum immunofixation electrophoresis (sIFE) and urine (uIFE) immunofixation electrophoresis for classification of complete response (CR). However, uIFE is not always performed for sIFE-negative patients. We analyzed M-protein evaluations from 384 MM patients (excluding those with light-chain-only disease) treated in the GEM2012MENOS65 (NCT01916252) trial to determine the uIFE-positive rate in patients who became sIFE-negative posttreatment and evaluate rates of minimal residual disease (MRD)-negative status and progression-free survival (PFS) among patients achieving CR, CR but without uIFE available (uncertain CR; uCR), or very good partial response (VGPR). Among 107 patients with M-protein exclusively in serum at diagnosis who became sIFE-negative posttreatment and who had uIFE available, the uIFE-positive rate was 0%. Among 161 patients with M-protein in both serum and urine at diagnosis who became sIFE-negative posttreatment, 3 (1.8%) were uIFE positive. Among patients achieving CR vs uCR, there were no significant differences in postconsolidation MRD-negative ( |
| نوع الوثيقة: | article in journal/newspaper |
| اللغة: | English |
| تدمد: | 1528-0020 |
| العلاقة: | http://hdl.handle.net/10668/13863Test; https://ashpublications.org/blood/article-pdf/133/25/2664/1557496/bloodbld2019000671.pdfTest |
| DOI: | 10.1182/blood.2019000671 |
| الإتاحة: | https://doi.org/10.1182/blood.2019000671Test http://hdl.handle.net/10668/13863Test https://ashpublications.org/blood/article-pdf/133/25/2664/1557496/bloodbld2019000671.pdfTest |
| حقوق: | open access |
| رقم الانضمام: | edsbas.1F9AD658 |
| قاعدة البيانات: | BASE |
Full Text Finder | تدمد: | 15280020 |
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| DOI: | 10.1182/blood.2019000671 |